DRSC/TRiP Functional Genomics Resources

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Protein Alignment PAX1 and Poxm

DIOPT Version :9

Sequence 1:NP_006183.2 Gene:PAX1 / 5075 HGNCID:8615 Length:534 Species:Homo sapiens
Sequence 2:NP_001036687.1 Gene:Poxm / 40990 FlyBaseID:FBgn0003129 Length:370 Species:Drosophila melanogaster


Alignment Length:341 Identity:160/341 - (46%)
Similarity:178/341 - (52%) Gaps:108/341 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    99 YGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPG 163
            ||||||||||||||||||||.|:||||||:||||||||||||||||||||||||||:||||||||
  Fly    10 YGEVNQLGGVFVNGRPLPNATRMRIVELARLGIRPCDISRQLRVSHGCVSKILARYHETGSILPG 74

Human   164 AIGGSKPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGSL 228
            ||||||||||||.||.:||:.||.||||||||||||||::|:|||.|||||||||||||||:|||
  Fly    75 AIGGSKPRVTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVPSVSSISRILRNKLGSL 139

Human   229 AQ---PGPYEAS------------------------------KQPPSQPTLP------------- 247
            ..   ||....|                              ..|...|..|             
  Fly   140 GHQHTPGTVMGSGSSSGGGSVSSNGGQNNGTSASNNINLSNLGNPGGGPHHPHHHHHHQSAAAAA 204

Human   248 ---------------YNHIYQYPYP------------SPVSPTGA-KMGS--HPGVPGTAGHVSI 282
                           ||.||| ||.            ||..|.|| ..||  ||....:....:.
  Fly   205 SAHHVHAHAHAHAHLYNSIYQ-PYSAAAAYSMKTPCGSPSPPQGAGGQGSVPHPHQLRSVAAAAA 268

Human   283 PRSWPSAHSVSNILGIRTFMEQTGAL------------AGSEGTAYSPKMEDWAGVNRTAFPATP 335
            ...|||:||||:||.    ..|..||            .|..|:..||            .|.||
  Fly   269 AAHWPSSHSVSDILA----HHQAVALRASCQVGVGVGGMGGMGSTVSP------------LPMTP 317

Human   336 A-VNGLE--KPALEAD 348
            : |.|..  :|.|:.:
  Fly   318 SPVAGTAGGQPLLDCE 333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PAX1NP_006183.2 PAX 98..225 CDD:238076 111/125 (89%)
PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381 101..157 51/55 (93%)
RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381 176..224 37/47 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 424..480
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 492..511
PoxmNP_001036687.1 PAX 10..133 CDD:128645 108/122 (89%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149794
Domainoid 1 1.000 225 1.000 Domainoid score I2542
eggNOG 1 0.900 - - E1_KOG3517
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 247 1.000 Inparanoid score I3265
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1339212at2759
OrthoFinder 1 1.000 - - FOG0003351
OrthoInspector 1 1.000 - - otm40766
orthoMCL 1 0.900 - - OOG6_106145
Panther 1 1.100 - - LDO PTHR45636
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3849
SonicParanoid 1 1.000 - - X2237
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.790

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