DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAX1 and al

DIOPT Version :9

Sequence 1:	NP_006183.2	Gene:	PAX1 / 5075	HGNCID:	8615	Length:	534	Species:	Homo sapiens
Sequence 2:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	314	Identity:	65/314 - (20%)
Similarity:	95/314 - (30%)	Gaps:	161/314 - (51%)

- Green bases have known domain annotations that are detailed below.

Human   222 RNKIGSLAQP-GPY----EASKQ-------PPSQPTLPYNHI------------------YQYPY 256
            :.|:|..:.| .||    .|:.|       ||:    |:.|:                  ::||:
  Fly   143 QEKVGPQSHPYNPYLPGGAATMQTVVGAALPPN----PFTHLGFQLRKPFDAQHAANLAAFRYPH 203

Human   257 PS--PVSPTG-----AKMGSHPGVPGTAGHVSIPRSWPSAHSVSNILGIRTFMEQTGALAGSEGT 314
            .|  |:.|:|     .:...|....|.||..|     ||: |..::|
  Fly   204 LSAAPMIPSGYFNQFQRAPPHMLPHGMAGMYS-----PSS-SFQSLL------------------ 244

Human   315 AYSPKMEDWAGVNRTAFP-ATPAVNGLEKPALEADIKYTQSASTLSAVGGFLPACAYPASNQHGV 378
                       .|.||.| .||    |.||                      ||....:.:.|
  Fly   245 -----------ANMTAVPRGTP----LGKP----------------------PALLVGSPDLH-- 270

Human   379 YSAPGGGYLAPGPPWPPAQG--------------PPLAPPGAGVAVHGGELA------------- 416
              :|  .::...||..||.|              ||.|||...|.|...:|:
  Fly   271 --SP--NHMLASPPTSPASGHASQHQQHPTAHPPPPQAPPQMPVGVQPAQLSPQHLVGIALTQQA 331

Human   417 ----------AAMTFKH-PSREGSLPAPAARPRTPSVAYTDCPSRPRPPRGSSP 459
                      .|:|..| |.|:  ||.|:.:            :.|.|||.::|
  Fly   332 SSLSPTQTSPVALTLSHSPQRQ--LPPPSHQ------------APPPPPRAATP 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAX1	NP_006183.2	PAX	98..225	CDD:238076	0/2 (0%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	101..157
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	176..224		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..480		10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..511
al	NP_722629.1	Homeobox	89..141	CDD:278475
al	NP_722629.1	OAR	374..391	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910