DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DCAF8 and Dcaf8

DIOPT Version :9

Sequence 1:	NP_056541.2	Gene:	DCAF8 / 50717	HGNCID:	24891	Length:	597	Species:	Homo sapiens
Sequence 2:	NP_001344133.1	Gene:	Dcaf8 / 98193	MGIID:	91860	Length:	591	Species:	Mus musculus

Alignment Length:	598	Identity:	571/598 - (95%)
Similarity:	583/598 - (97%)	Gaps:	8/598 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSK-GSSTDGRTDLANGSLSSSPEEMSGAEEGRETSSGIEVEASDLSLSLTGDDGGPNRTSTES 64
            ||:| .::|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MSNKRPNTTDGRTDLANGSLSSSPEEMSGAEEGRETSSGIEVEASDLSLSLTGDDGGPNRTSTES 65

Human    65 RGTDTESSGEDKDSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDS 129
            ||||||||||:|||||||||||||||||:|.|..|       :||:|||||.|.|||||:|||||
Mouse    66 RGTDTESSGEEKDSDSMEDTGHYSINDESRGHGHS-------DEEDEEQPRHRGQRKRASRDQDS 123

Human   130 SDDERALEDWVSSETSALPRPRWQALPALRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTG 194
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   124 SDDERALEDWVSSETTALPRPRWQALPALRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTG 188

Human   195 CVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFESGHKSNVFQAKFLPNSGDSTLAMCARD 259
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   189 CVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFESGHKSNVFQAKFLPNSGDSTLAMCARD 253

Human   260 GQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLSAGEDAVVFTIDLRQDRPASKLVV 324
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   254 GQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLSAGEDAVVFTIDLRQDRPASKLVV 318

Human   325 TKEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQRKIDENENNGVLKKFCPHHLVNSESKAN 389
            ||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||
Mouse   319 TKEKEKKVGLYTIYVNPANTHQFAVGGRDQYVRIYDQRKIDENENNGVLKKFCPHHLVNSESKAN 383

Human   390 ITCLVYSHDGTELLASYNDEDIYLFNSSHSDGAQYVKRYKGHRNNATVKGVNFYGPKSEFVVSGS 454
            |||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
Mouse   384 ITCLVYSHDGTELLASYNDEDIYLFNSSHSDGAQYIKRYKGHRNNATVKGVNFYGPKSEFVVSGS 448

Human   455 DCGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPTAEASTELTGLK 519
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   449 DCGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPTAEASTELTGLK 513

Human   520 DVIKKNKRERDEDSLHQTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGATDADSDESPSSSDTSD 584
            :|||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   514 EVIKKNKRERDEDSLHHTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGATDADSDESPSSSDTSD 578

Human   585 EEEGPDRVQCMPS 597
            |||||||||||||
Mouse   579 EEEGPDRVQCMPS 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCAF8	NP_056541.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..147		123/146 (84%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:22500989	39..50		10/10 (100%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:22500989	114..122		5/7 (71%)
		WD40	189..506	CDD:392136	314/316 (99%)
		WD 1	191..230		38/38 (100%)
		WD40 repeat	198..234	CDD:293791	35/35 (100%)
		WD 2	234..275		40/40 (100%)
		WD40 repeat	240..281	CDD:293791	40/40 (100%)
		WD 3	281..321		39/39 (100%)
		WD40 repeat	286..327	CDD:293791	40/40 (100%)
		WD 4	329..369		38/39 (97%)
		WD40 repeat	335..383	CDD:293791	46/47 (98%)
		WD 5	385..424		38/38 (100%)
		WD40 repeat	390..429	CDD:293791	37/38 (97%)
		WD 6	432..472		39/39 (100%)
		WD40 repeat	437..474	CDD:293791	36/36 (100%)
		WD 7	476..515		38/38 (100%)
		WD40 repeat	481..505	CDD:293791	23/23 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..597		38/38 (100%)
Dcaf8	NP_001344133.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..140		123/145 (85%)
		2A1904	<17..177	CDD:273344	148/166 (89%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q5TAQ9	40..51		10/10 (100%)
		WD40	183..500	CDD:392136	314/316 (99%)
		WD 1	185..224		38/38 (100%)
		WD40 repeat	192..228	CDD:293791	35/35 (100%)
		WD 2	228..269		40/40 (100%)
		WD40 repeat	234..275	CDD:293791	40/40 (100%)
		WD 3	275..315		39/39 (100%)
		WD40 repeat	280..321	CDD:293791	40/40 (100%)
		WD 4	323..363		38/39 (97%)
		WD40 repeat	329..377	CDD:293791	46/47 (98%)
		WD 5	379..418		38/38 (100%)
		WD40 repeat	384..423	CDD:293791	37/38 (97%)
		WD 6	426..466		39/39 (100%)
		WD40 repeat	431..468	CDD:293791	36/36 (100%)
		WD 7	470..509		38/38 (100%)
		WD40 repeat	475..499	CDD:293791	23/23 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..591		38/38 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83955622
Domainoid	1	1.000	412	1.000	Domainoid score	I10906
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56725
Inparanoid	1	1.050	1167	1.000	Inparanoid score	I4584
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48013
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	1	1.000	-	-		FOG0003170
OrthoInspector	1	1.000	-	-		oto126021
orthoMCL	1	0.900	-	-		OOG6_103613
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	1	1.000	-	-		X2134
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.440