Protein Alignment DCAF8 and adp

DIOPT Version :10

• Sequence 1: NP_056541.2
• Gene: DCAF8 / 50717
• HGNCID: 24891
• Length: 597
• Species: Homo sapiens
• Sequence 2: NP_611296.2
• Gene: adp / 37073
• FlyBaseID: FBgn0000057
• Length: 628
• Species: Drosophila melanogaster
• Alignment Length: 602
• Identity: 141/602 - (23%)
• Similarity: 216/602 - (35%)
• Gaps: 239/602 - (39%)

Human   158 LRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDW 222
            ||.|.|.|.|           :|.|...:..|.||.||||.|.:...|.||||||||.:|::||.
  Fly    43 LRRRLLASPA-----------YVDRLEQEAVLVGHEGCVNCLEWTTDGMWLASGSDDYRVMIWDP 96

Human   223 VRRQPVLDFESGHKSNVFQAKFLPNSGDSTLAMCARDGQVRVAEL-----SATQC-CKNTKRVAQ 281
            .|::.|....:.|..|||..||||.:.:|.:|.||.|..:.|.::     :...| |
  Fly    97 FRKKLVHVIRTKHLGNVFSVKFLPKTNNSIVATCAADKFIYVYDINDPNETLFSCIC-------- 153

Human   282 HKGASHKLALEPDSPCTFLSAGEDAVVFTIDLRQD---RPAS----KLVVTKEKEKKVGLYTIYV 339
            |...:.:||...|||..|.|||||..:..:|:|:.   ||..    :|:...::.:......:.:
  Fly   154 HFSRAKRLATAQDSPHVFWSAGEDGCILQLDIREPHRCRPEEGIGVRLLNLHDQLENTEAKCLAI 218

Human   340 NPANTHQFAVGGRDQFVRIYDQRKIDENENNGV---LKKFCPHHLVNSESK------ANITCLVY 395
            ||..|...|||..|.|.|:||:||:.....||:   :..:.|..:|.:.|:      ..||.|.:
  Fly   219 NPRRTEYLAVGTNDPFARVYDRRKLPSTNGNGLSACVAYYAPGQIVKNISRNIVHEPRGITYLTF 283

Human   396 SHDGTELLASYNDEDIYLFNSSHS----------------------------------------- 419
            :.:|||||.:...|.:|.|:.:|:
  Fly   284 NGNGTELLVNIGCEHVYRFDLNHAEPPVFYDLPAFTSTLVHEEEPVKMPHRSRSLPTEIEVYKKE 348

Human   420 ----------------------------------------------------------------- 419
                                                                             
  Fly   349 GNDFLENGKLVDAIDAYSAALAKYPQGEVLYLNRATALMRRGWFGDIYAALRDCHEALRLDPSYV 413

Human   420 ----------------------------------------------------------------- 419
                                                                             
  Fly   414 KAHFRLARALLELHRPQDADQCLQALIQRFPDFANNHGVLMLNKDIKENRRQSKSPEAPELQPVE 478

Human   420 --DGAQYVK-----------------RYKGHRNNAT-VKGVNFYGPKSEFVVSGSDCGHIFLWEK 464
              ||.:|::                 ||.||.|..| :|..|:.|.:.||:.:|||.|::::||.
  Fly   479 VDDGFRYLRLKNAEYDLRSTARDYMQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEG 543

Human   465 SSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPTAEASTELTGL-KDVIK----- 523
            .:.:|......| ..:|||::|||.:.:|||||:||::|||:|.|.::.|...| .||.:
  Fly   544 DTGKIRAVYRAD-SAIVNCVQPHPSICMLATSGIDHNIKIWSPCAASAEERPNLVADVTRFVEDN 607

Human   524 KNKRERDEDSLHQTDLF 540
            :.|...|...||..:.:
  Fly   608 QEKMRLDPFELHTRNAY 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCAF8	NP_056541.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..147
		Nuclear export signal. /evidence=ECO:0000269|PubMed:22500989	39..50
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22500989	114..122
		WD40	189..506	CDD:475233	122/529 (23%)
		WD 1	191..230		21/38 (55%)
		WD40 repeat	198..234	CDD:293791	15/35 (43%)
		WD 2	234..275		16/46 (35%)
		WD40 repeat	240..281	CDD:293791	13/46 (28%)
		WD 3	281..321		16/46 (35%)
		WD40 repeat	286..327	CDD:293791	16/47 (34%)
		WD 4	329..369		13/39 (33%)
		WD40 repeat	335..383	CDD:293791	16/50 (32%)
		WD 5	385..424		15/217 (7%)
		WD40 repeat	390..429	CDD:293791	16/228 (7%)
		WD 6	432..472		14/40 (35%)
		WD40 repeat	437..474	CDD:293791	12/36 (33%)
		WD 7	476..515		19/38 (50%)
		WD40 repeat	481..505	CDD:293791	14/23 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	558..597
adp	NP_611296.2	WD40	54..>242	CDD:475233	68/195 (35%)
		WD40 repeat	72..108	CDD:293791	15/35 (43%)
		WD40 repeat	114..154	CDD:293791	13/47 (28%)
		WD40 repeat	158..203	CDD:293791	16/44 (36%)
		WD40 repeat	214..268	CDD:293791	17/53 (32%)
		Spy	338..>461	CDD:443119	0/122 (0%)
		TPR repeat	342..370	CDD:276809	0/27 (0%)
		TPR repeat	375..408	CDD:276809	0/32 (0%)
		TPR repeat	413..441	CDD:276809	0/27 (0%)
		WD40 repeat	513..553	CDD:293791	13/39 (33%)
		WD40	<526..584	CDD:475233	25/58 (43%)