DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCAF8 and Dcaf8

DIOPT Version :9

Sequence 1:	NP_056541.2	Gene:	DCAF8 / 50717	HGNCID:	24891	Length:	597	Species:	Homo sapiens
Sequence 2:	NP_001014253.1	Gene:	Dcaf8 / 364050	RGDID:	1308513	Length:	591	Species:	Rattus norvegicus

Alignment Length:	597	Identity:	579/597 - (96%)
Similarity:	584/597 - (97%)	Gaps:	6/597 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSKGSSTDGRTDLANGSLSSSPEEMSGAEEGRETSSGIEVEASDLSLSLTGDDGGPNRTSTESR 65
            ||||..|||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MSSKRPSTDGRRDLANGSLSSSPEEMSGAEEGRETSSGIEVEASDLSLSLTGDDGGPNRTSTESR 65

Human    66 GTDTESSGEDKDSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSS 130
            |||||||||:|||||||||||||||||||||..|      :|||||||||.|||||||:||||||
  Rat    66 GTDTESSGEEKDSDSMEDTGHYSINDENRVHGHS------DEEEEEEQPRHRVQRKRASRDQDSS 124

Human   131 DDERALEDWVSSETSALPRPRWQALPALRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTGC 195
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   125 DDERALEDWVSSETTALPRPRWQALPALRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTGC 189

Human   196 VNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFESGHKSNVFQAKFLPNSGDSTLAMCARDG 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   190 VNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFESGHKSNVFQAKFLPNSGDSTLAMCARDG 254

Human   261 QVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLSAGEDAVVFTIDLRQDRPASKLVVT 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   255 QVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLSAGEDAVVFTIDLRQDRPASKLVVT 319

Human   326 KEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQRKIDENENNGVLKKFCPHHLVNSESKANI 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   320 KEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQRKIDENENNGVLKKFCPHHLVNSESKANI 384

Human   391 TCLVYSHDGTELLASYNDEDIYLFNSSHSDGAQYVKRYKGHRNNATVKGVNFYGPKSEFVVSGSD 455
            ||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||
  Rat   385 TCLVYSHDGTELLASYNDEDIYLFNSSHSDGAQYIKRYKGHRNNATVKGVNFYGPKSEFVVSGSD 449

Human   456 CGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPTAEASTELTGLKD 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   450 CGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPTAEASTELTGLKD 514

Human   521 VIKKNKRERDEDSLHQTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGATDADSDESPSSSDTSDE 585
            |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   515 VIKKNKRERDEDSLHHTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGATDADSDESPSSSDTSDE 579

Human   586 EEGPDRVQCMPS 597
            ||||||||||||
  Rat   580 EEGPDRVQCMPS 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCAF8	NP_056541.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..147		129/145 (89%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:22500989	39..50		10/10 (100%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:22500989	114..122		6/7 (86%)
		WD40	189..506	CDD:392136	315/316 (100%)
		WD 1	191..230		38/38 (100%)
		WD40 repeat	198..234	CDD:293791	35/35 (100%)
		WD 2	234..275		40/40 (100%)
		WD40 repeat	240..281	CDD:293791	40/40 (100%)
		WD 3	281..321		39/39 (100%)
		WD40 repeat	286..327	CDD:293791	40/40 (100%)
		WD 4	329..369		39/39 (100%)
		WD40 repeat	335..383	CDD:293791	47/47 (100%)
		WD 5	385..424		38/38 (100%)
		WD40 repeat	390..429	CDD:293791	37/38 (97%)
		WD 6	432..472		39/39 (100%)
		WD40 repeat	437..474	CDD:293791	36/36 (100%)
		WD 7	476..515		38/38 (100%)
		WD40 repeat	481..505	CDD:293791	23/23 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..597		38/38 (100%)
Dcaf8	NP_001014253.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..140		129/144 (90%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q5TAQ9	39..50		10/10 (100%)
		WD40	183..500	CDD:295369	315/316 (100%)
		WD40	183..>499	CDD:225201	314/315 (100%)
		WD 1	185..224		38/38 (100%)
		WD40 repeat	192..228	CDD:293791	35/35 (100%)
		WD 2	228..269		40/40 (100%)
		WD40 repeat	234..275	CDD:293791	40/40 (100%)
		WD 3	275..315		39/39 (100%)
		WD40 repeat	280..321	CDD:293791	40/40 (100%)
		WD 4	323..363		39/39 (100%)
		WD40 repeat	329..377	CDD:293791	47/47 (100%)
		WD 5	379..418		38/38 (100%)
		WD40 repeat	384..423	CDD:293791	37/38 (97%)
		WD 6	426..466		39/39 (100%)
		WD40 repeat	431..468	CDD:293791	36/36 (100%)
		WD 7	470..509		38/38 (100%)
		WD40 repeat	475..499	CDD:293791	23/23 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..591		38/38 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83681155
Domainoid	1	1.000	413	1.000	Domainoid score	I10322
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56725
Inparanoid	1	1.050	1184	1.000	Inparanoid score	I4185
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48013
OrthoDB	1	1.010	-	-		D107133at32523
OrthoFinder	1	1.000	-	-		FOG0003170
OrthoInspector	1	1.000	-	-		oto142111
orthoMCL	1	0.900	-	-		OOG6_103613
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2134
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.410