Protein Alignment PRKN and ITT1

DIOPT Version :10

• Sequence 1: XP_016866397.1
• Gene: PRKN / 5071
• HGNCID: 8607
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_013643.1
• Gene: ITT1 / 854934
• SGDID: S000004533
• Length: 464
• Species: Saccharomyces cerevisiae
• Alignment Length: 301
• Identity: 65/301 - (21%)
• Similarity: 100/301 - (33%)
• Gaps: 80/301 - (26%)

Human   249 KCGAHPTSD--KETSVALHLIATNSRNITCITCTDVRSPVLVFQ-----CNSRHVICLDCFHLYC 306
            ||......|  |:.|....|...:..|..|..|.::...|.:.:     .|..|.:|..|...|.
Yeast   151 KCLTQDQYDLFKQISEEATLQKVSRSNYHCCICMEMEKGVRMIKLPCENANVEHYLCRGCAKSYF 215

Human   307 VTRLNDRQF--VHDPQLGYS------------------LPCVAGCPNSLIKELHHFRILGEEQYN 351
            ...:.:.:.  |..||..|.                  .|.:   |.|.:||     ::..|...
Yeast   216 TAMIQENRISSVRCPQCEYKELKLEDFKSYKKMLKALFTPLI---PVSFLKE-----VIDTELCE 272

Human   352 RYQQYGAEECVLQMGG------VLCPRPGCGAGLLPEP-DQRKVTCEGGNGLGCGFAFCRECKEA 409
            ||::....:...::..      |.|.|  |.:....|. |...:.|:     .|.|.||.:|..|
Yeast   273 RYEKMFYNQAATRLSKYCPYACVTCRR--CDSWCTKEDLDDAMIQCQ-----KCHFVFCFDCLHA 330

Human   410 YH--EGECSAVFEASGTTTQAY-------------------------RVDERAAEQARWEAASKE 447
            :|  ..:|......|....:.|                         .|::..||:....|..||
Yeast   331 WHGYNNKCGKKVSLSTDIIEEYLDDTVTSYERKRKLEAKYGRRVLELEVNDYLAEKMLDLAIKKE 395

Human   448 TIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCG 488
              ....:.||:|.|.||::.||..|||  ..|...:|:.||
Yeast   396 --GSNLQRCPKCKVVVERSEGCNKMKC--EVCGTLFCFICG 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKN	XP_016866397.1	Ubl_parkin	41..114	CDD:340496
		RING0_parkin	184..267	CDD:412057	5/19 (26%)
		zf-RING_14	266..354	CDD:465601	21/112 (19%)
		BRcat_RBR_parkin	339..417	CDD:439001	18/86 (21%)
		Rcat_RBR_parkin	447..501	CDD:439018	16/42 (38%)
ITT1	NP_013643.1	RWD_ScITT1-like	3..145	CDD:467645
		RING_Ubox	174..236	CDD:473075	13/61 (21%)
		IBR	272..334	CDD:214763	16/68 (24%)
		Rcat_RBR_RNF14	397..454	CDD:439015	15/38 (39%)