Protein Alignment PRKN and Prkn

DIOPT Version :10

• Sequence 1: XP_016866397.1
• Gene: PRKN / 5071
• HGNCID: 8607
• Length: 503
• Species: Homo sapiens
• Sequence 2: XP_063128104.1
• Gene: Prkn / 56816
• RGDID: 61797
• Length: 522
• Species: Rattus norvegicus
• Alignment Length: 493
• Identity: 394/493 - (79%)
• Similarity: 420/493 - (85%)
• Gaps: 30/493 - (6%)

Human    41 VFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIV 105
            ||||||||:|||||||||||||||||||||||||||||||||||||||:|..|||||||:|||||
  Rat    30 VFVRFNSSYGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELQNHLTVQNCDLEQQSIV 94

Human   106 HIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSP 170
            ||||||.||..|.||:|||.|::...|...||:|||||||||.:||.|||||||||.|||:.||.
  Rat    95 HIVQRPQRKSHETNASGGDKPQSTPEGSIWEPRSLTRVDLSSHILPADSVGLAVILDTDSKSDSE 159

Human   171 PAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTL--------------------- 214
            .|..|..:..|:||:|||||||.:||||||||||.|||||||||
  Rat   160 AARGPEAKPTYHSFFVYCKGPCHKVQPGKLRVQCGTCRQATLTLAQEDALGSGAREYQCTCYLMA 224

Human   215 ---------TQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATN 270
                     .||||||||||||||||||||||.||||.|||||||||||||||:|||||:||..|
  Rat   225 AKLSDKLSTNQGPSCWDDVLIPNRMSGECQSPDCPGTRAEFFFKCGAHPTSDKDTSVALNLITNN 289

Human   271 SRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSL 335
            ||:|.||.|||||:||||||||.|||||||||||||||||||||||||.||||||||||||||||
  Rat   290 SRSIPCIACTDVRNPVLVFQCNHRHVICLDCFHLYCVTRLNDRQFVHDAQLGYSLPCVAGCPNSL 354

Human   336 IKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGF 400
            |||||||||||||||||||||||||||||||||||||||||||||||..|:||||||||||||||
  Rat   355 IKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEQGQKKVTCEGGNGLGCGF 419

Human   401 AFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEK 465
            .|||:||||||||||.::|||||.|:||||||:|||||||||.||||||||||||||||:||:||
  Rat   420 VFCRDCKEAYHEGECDSMFEASGATSQAYRVDQRAAEQARWEEASKETIKKTTKPCPRCNVPIEK 484

Human   466 NGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 503
            ||||||||||||||:|||||||||||||.|||||||||
  Rat   485 NGGCMHMKCPQPQCKLEWCWNCGCEWNRACMGDHWFDV 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKN	XP_016866397.1	Ubl_parkin	41..114	CDD:340496	66/72 (92%)
		RING0_parkin	184..267	CDD:412057	73/112 (65%)
		zf-RING_14	266..354	CDD:465601	79/87 (91%)
		BRcat_RBR_parkin	339..417	CDD:439001	72/77 (94%)
		Rcat_RBR_parkin	447..501	CDD:439018	49/53 (92%)
Prkn	XP_063128104.1	None