Protein Alignment PRKN and Prkn

DIOPT Version :10

• Sequence 1: XP_016866397.1
• Gene: PRKN / 5071
• HGNCID: 8607
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_001390399.1
• Gene: Prkn / 50873
• MGIID: 1355296
• Length: 465
• Species: Mus musculus
• Alignment Length: 463
• Identity: 388/463 - (83%)
• Similarity: 417/463 - (90%)
• Gaps: 0/463 - (0%)

Human    41 VFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIV 105
            ||||||||:||||||||||||.||||||||||||||||||||||||||.|..|||||||:|||||
Mouse     3 VFVRFNSSYGFPVEVDSDTSILQLKEVVAKRQGVPADQLRVIFAGKELPNHLTVQNCDLEQQSIV 67

Human   106 HIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSP 170
            ||||||.|:..|.||:|||:|::.:.|...|.:|||||||||..||.|||||||||.|||::||.
Mouse    68 HIVQRPRRRSHETNASGGDEPQSTSEGSIWESRSLTRVDLSSHTLPVDSVGLAVILDTDSKRDSE 132

Human   171 PAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQ 235
            .|..||.:..||||::||||||.:||||||||||.||:||||||.||||||||||||||||||||
Mouse   133 AARGPAVKPTYNSFFIYCKGPCHKVQPGKLRVQCGTCKQATLTLAQGPSCWDDVLIPNRMSGECQ 197

Human   236 SPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLD 300
            ||.||||.|||||||||||||||:|||||:||.:|.|:|.||.||||||||||||||.|||||||
Mouse   198 SPDCPGTRAEFFFKCGAHPTSDKDTSVALNLITSNRRSIPCIACTDVRSPVLVFQCNHRHVICLD 262

Human   301 CFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQM 365
            ||||||||||||||||||.|||||||||||||||||||||||||||||||.||||||||||||||
Mouse   263 CFHLYCVTRLNDRQFVHDAQLGYSLPCVAGCPNSLIKELHHFRILGEEQYTRYQQYGAEECVLQM 327

Human   366 GGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYR 430
            |||||||||||||||||..||||||||||||||||.|||:||||||||:|.::.|.||.|:||||
Mouse   328 GGVLCPRPGCGAGLLPEQGQRKVTCEGGNGLGCGFVFCRDCKEAYHEGDCDSLLEPSGATSQAYR 392

Human   431 VDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVC 495
            ||:|||||||||.||||||||||||||||:||:||||||||||||||||:|||||||||||||.|
Mouse   393 VDKRAAEQARWEEASKETIKKTTKPCPRCNVPIEKNGGCMHMKCPQPQCKLEWCWNCGCEWNRAC 457

Human   496 MGDHWFDV 503
            ||||||||
Mouse   458 MGDHWFDV 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKN	XP_016866397.1	Ubl_parkin	41..114	CDD:340496	65/72 (90%)
		RING0_parkin	184..267	CDD:412057	71/82 (87%)
		zf-RING_14	266..354	CDD:465601	78/87 (90%)
		BRcat_RBR_parkin	339..417	CDD:439001	71/77 (92%)
		Rcat_RBR_parkin	447..501	CDD:439018	49/53 (92%)
Prkn	NP_001390399.1	Ubl_parkin	3..76	CDD:340496	65/72 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	70..96		13/25 (52%)
		RING0_parkin	146..229	CDD:412057	71/82 (87%)
		SYT11 binding 1. /evidence=ECO:0000250|UniProtKB:O60260	204..238		26/33 (79%)
		zf-RING_14	228..316	CDD:465601	78/87 (90%)
		TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221	234..465		206/230 (90%)
		SYT11 binding 2. /evidence=ECO:0000250|UniProtKB:O60260	257..293		34/35 (97%)
		BRcat_RBR_parkin	301..381	CDD:439001	71/79 (90%)
		REP. /evidence=ECO:0000250|UniProtKB:Q9JK66	378..410		22/31 (71%)
		Rcat_RBR_parkin	409..463	CDD:439018	49/53 (92%)