DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKN and park

DIOPT Version :9

Sequence 1:	XP_016866397.1	Gene:	PRKN / 5071	HGNCID:	8607	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_730600.1	Gene:	park / 40336	FlyBaseID:	FBgn0041100	Length:	482	Species:	Drosophila melanogaster

Alignment Length:	479	Identity:	203/479 - (42%)
Similarity:	285/479 - (59%)	Gaps:	39/479 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    37 YPITVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQ 101
            :.::::|:.|:.....|.::....|..:||:||.:.|:..|.|::|||||||.:..|::.|||.|
  Fly    28 HTLSIYVKTNTGKTLTVNLEPQWDIKNVKELVAPQLGLQPDDLKIIFAGKELSDATTIEQCDLGQ 92

Human   102 QSIVHIVQ-RPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDS 165
            ||::|.:: ||..:.|::.:...::...:......:|.:.|.:||.              |.::.
  Fly    93 QSVLHAIRLRPPVQRQKIQSATLEEEEPSLSDEASKPLNETLLDLQ--------------LESEE 143

Human   166 R---KDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIP 227
            |   .|.....:.|      .|:|:| ..|.::..|||||:|:.|:....|:.:.|.||||||..
  Fly   144 RLNITDEERVRAKA------HFFVHC-SQCDKLCNGKLRVRCALCKGGAFTVHRDPECWDDVLKS 201

Human   228 NRMSGECQSPH--CPGTS------AEFFFKCGAHPT-SDKETSVALHLIATNSRNITCITCTDVR 283
            .|:.|.|:|..  |...:      |||||||..|.: .:|:.:..|:||..|.:|:.|:.||||.
  Fly   202 RRIPGHCESLEVACVDNAAGDPPFAEFFFKCAEHVSGGEKDFAAPLNLIKNNIKNVPCLACTDVS 266

Human   284 SPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEE 348
            ..||||.|.|:||.|:|||..||.:||.:|||:..|..||:|||.|||.:|.|:|:|||::|..|
  Fly   267 DTVLVFPCASQHVTCIDCFRHYCRSRLGERQFMPHPDFGYTLPCPAGCEHSFIEEIHHFKLLTRE 331

Human   349 QYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEG 413
            :|:|||::..||.|||.||||||:||||.|||.|||.|||||:.    |||:.|||.|.:.||.|
  Fly   332 EYDRYQRFATEEYVLQAGGVLCPQPGCGMGLLVEPDCRKVTCQN----GCGYVFCRNCLQGYHIG 392

Human   414 EC-SAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQP 477
            || .....||.|.:..|.||...|.:|||:.||..|||.:|||||:|..|.|::||||||.|.:.
  Fly   393 ECLPEGTGASATNSCEYTVDPNRAAEARWDEASNVTIKVSTKPCPKCRTPTERDGGCMHMVCTRA 457

Human   478 QCRLEWCWNCGCEWNRVCMGDHWF 501
            .|..||||.|..||.|.|||.|||
  Fly   458 GCGFEWCWVCQTEWTRDCMGAHWF 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKN	XP_016866397.1	None
park	NP_730600.1	UBQ	30..97	CDD:214563	25/66 (38%)
		parkin_N	32..101	CDD:176393	26/68 (38%)
		IBR	334..390	CDD:214763	36/59 (61%)
		IBR	<435..471	CDD:279784	19/35 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155009
Domainoid	1	1.000	120	1.000	Domainoid score	I5771
eggNOG	1	0.900	-	-		E1_KOG0006
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3355
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1922
Isobase	1	0.950	-	0	Normalized mean entropy	S2577
OMA	1	1.010	-	-		QHG46525
OrthoDB	1	1.010	-	-		D1140368at2759
OrthoFinder	1	1.000	-	-		FOG0006338
OrthoInspector	1	1.000	-	-		oto90449
orthoMCL	1	0.900	-	-		OOG6_108992
Panther	1	1.100	-	-	LDO	PTHR11685
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4411
SonicParanoid	1	1.000	-	-		X5292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750