Protein Alignment PRKN and rnf14.4

DIOPT Version :10

• Sequence 1: XP_016866397.1
• Gene: PRKN / 5071
• HGNCID: 8607
• Length: 503
• Species: Homo sapiens
• Sequence 2: XP_031754667.1
• Gene: rnf14.4 / 100485068
• XenbaseID: XB-GENE-22064479
• Length: 492
• Species: Xenopus tropicalis
• Alignment Length: 562
• Identity: 125/562 - (22%)
• Similarity: 191/562 - (33%)
• Gaps: 175/562 - (31%)

Human    28 RLYTRPEREYPITVFVR-------------------FNSSHGFPVEVDSDTSIFQLKEVVAKRQG 73
            ||...|.||.....|.:                   ||..|..|:..:...:  |..|::|
 Frog     4 RLVFVPGREVATETFAQVGGTVKDIYSWCSPHQLLSFNDLHRQPMAKEDKEA--QEDELLA---- 62

Human    74 VPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGG------DDPRNAA-- 130
                 |..|::..|.:...|                          |.||      |.|.|.:
 Frog    63 -----LASIYSEDEFKRSET--------------------------ALGGKICVCLDLPPNFSVA 96

Human   131 --GGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQ 193
              |.|..:..:.: .:...|.||      .:||:.:.....|....||       |.:.||.
 Frog    97 IKGDCVSDEYAKS-FEYIVSFLP------PIILNFELPPGYPSTDPPA-------FTLSCKW--- 144

Human   194 RVQPGKLRVQCST--------------------CRQATLTLTQGPSCWDDVLIPNRMSGECQ-SP 237
             :.|.:|.:.|..                    .::.||...:..|.::..:        |: .|
 Frog   145 -LSPSQLALLCQRLDDLWEKYAGGVVLFAWMQFLKEGTLEYLKINSPYEIQV--------CEFGP 200

Human   238 HCPGTSAEFFFKCGAHPTSDKETSV----ALHLIATNSRNITCI---------TCTDVRSPVLVF 289
            .|...::.....|.|  |...|..:    |:..:.:.|..|.||         .|.|.:    .:
 Frog   201 QCIKNNSGISDSCSA--TGPAEAVIWDTRAIQDMKSVSALIECILDFNEAQQKKCFDSK----WY 259

Human   290 QCNSRHVICL------------DCFHLYCVTRLNDRQFV--HDPQLGYSLPCVAGCPNSLIKELH 340
            .||    ||.            .|.|:||...|.|...|  .|.|: .:|.|.....:|:.....
 Frog   260 MCN----ICFLEKVGSECTHFKKCEHIYCNACLKDYYTVQIQDGQV-QALNCPEPKCSSVATPAQ 319

Human   341 HFRILGEEQYNRYQQYGAEECVLQMGGVL-CPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCR 404
            ...::|||.::||.:...:..:..|..|: ||||.|....:.||..:...|.     .|.:|||.
 Frog   320 VKLLVGEEFFSRYDRLLLQSSLDLMADVVYCPRPNCRTPFILEPGAKMGICS-----SCKYAFCT 379

Human   405 ECKEAYHE-GECSAVFEASGTTTQAYRVDERAAE---QARW---------EAASKETIKKTTKPC 456
            .||.|||. ..|:...|......:.|...:.|.:   :.|:         |..|.|.::|.:|.|
 Frog   380 LCKLAYHAVAYCNITQEKLLLVREEYLEADEAGKKLLEKRYGKNVIVKAVEMKSFEWVEKNSKRC 444

Human   457 PRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGD 498
            |.|.|.:||:|||..|.|  ..|:..:||||....:|   ||
 Frog   445 PNCRVNIEKSGGCFVMFC--TACKENFCWNCSVVLSR---GD 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKN	XP_016866397.1	Ubl_parkin	41..114	CDD:340496	12/91 (13%)
		RING0_parkin	184..267	CDD:412057	17/107 (16%)
		zf-RING_14	266..354	CDD:465601	26/110 (24%)
		BRcat_RBR_parkin	339..417	CDD:439001	25/79 (32%)
		Rcat_RBR_parkin	447..501	CDD:439018	22/52 (42%)
rnf14.4	XP_031754667.1	RWD_RNF14	56..182	CDD:467656	29/178 (16%)
		RING-HC_RBR_RNF14	254..312	CDD:438290	16/66 (24%)
		BRcat_RBR_RNF14	341..397	CDD:439002	20/60 (33%)
		Rcat_RBR_RNF14	430..485	CDD:439015	24/57 (42%)