Protein Alignment PRKN and rnf19a

DIOPT Version :10

• Sequence 1: XP_016866397.1
• Gene: PRKN / 5071
• HGNCID: 8607
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_001116899.1
• Gene: rnf19a / 100144656
• XenbaseID: XB-GENE-852864
• Length: 797
• Species: Xenopus tropicalis
• Alignment Length: 253
• Identity: 61/253 - (24%)
• Similarity: 92/253 - (36%)
• Gaps: 89/253 - (35%)

Human   288 VFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNR 352
            :..|:  |..|.||...|.      |..:.:.::..|      ||..            .|::|.
 Frog   118 IMTCH--HRSCADCLRQYL------RIEISESRVNIS------CPEC------------SERFNP 156

Human   353 Y------------QQYGAEECVLQMGGVL------CPRPGCGAGLL-------PEPDQRKVTCEG 392
            |            ::|  ||.:|:...|.      ||.|.||..::       |     |:||
 Frog   157 YDIRLILNDDVLMEKY--EEFMLRRWLVADPDCRWCPAPDCGFAVIAFGCASCP-----KLTC-- 212

Human   393 GNGLGCGFAFCRECKEAYHEGE-CSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPC 456
            |.. |||..||..||:.:|..: |.|..:....:.:...:...:...::...|:.:.|    |||
 Frog   213 GRD-GCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDI----KPC 272

Human   457 PRCHVPVEK--NGGCMHMKCPQPQCRLEWCWNC-------------GC------EWNR 493
            |||...:.|  :|.|.||.|  ..|..|:||.|             ||      .|:|
 Frog   273 PRCAAYIIKMNDGSCNHMTC--AVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSR 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKN	XP_016866397.1	Ubl_parkin	41..114	CDD:340496
		RING0_parkin	184..267	CDD:412057
		zf-RING_14	266..354	CDD:465601	13/77 (17%)
		BRcat_RBR_parkin	339..417	CDD:439001	27/103 (26%)
		Rcat_RBR_parkin	447..501	CDD:439018	22/68 (32%)
rnf19a	NP_001116899.1	RING-HC_RBR_RNF19A	101..156	CDD:438431	11/63 (17%)
		BRcat_RBR_RNF19A	162..244	CDD:439023	25/91 (27%)
		Rcat_RBR_RNF19	266..334	CDD:439016	22/69 (32%)