DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAK3 and hpo

DIOPT Version :9

Sequence 1:	NP_001121640.1	Gene:	PAK3 / 5063	HGNCID:	8592	Length:	580	Species:	Homo sapiens
Sequence 2:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	325	Identity:	121/325 - (37%)
Similarity:	190/325 - (58%)	Gaps:	21/325 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   246 IASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKI 310
            ::.|.|.:  |....:.|.:||..:      .|..|:::|.:|:         .|:|.:....|:
  Fly     1 MSEPEVTS--VVDMKSPNISSSCSF------FKLKKLSEESLLQ---------PPEKVFDIMYKL 48

Human   311 GQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 375
            |:|:.|:||.|:...:...||||.:.::....:  ||.||.:|::..:|.:|.|..||....:||
  Fly    49 GEGSYGSVYKAVHKESSSIVAIKLVPVESDLHE--IIKEISIMQQCDSPYVVRYYGSYFKQYDLW 111

Human   376 VVMEYLAGGSLTDV--VTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVK 438
            :.|||...||::|:  :.:..:.|.:||.:..:.||.|.:||..:.||||||:.||||..:|..|
  Fly   112 ICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAK 176

Human   439 LTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 503
            |.|||...|:|...:||:|::|||:||||||:....|....|||||||.|:||.||:|||...:|
  Fly   177 LADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHP 241

Human   504 LRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 568
            :||:::|.....|..:.|:|.|..|.||:::||..:.|.|.:|.|||:|.|::.||..|.|.|::
  Fly   242 MRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPML 306

Human 569 568
Fly 307 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAK3	NP_001121640.1	PBD	69..162	CDD:307091
PAK3	NP_001121640.1	STKc_PAK3	284..580	CDD:132987	113/287 (39%)
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	105/256 (41%)
		S_TKc	42..293	CDD:214567	103/252 (41%)
		Mst1_SARAH	608..655	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910