Protein Alignment PAK3 and pak-1

DIOPT Version :9

• Sequence 1: NP_001121640.1
• Gene: PAK3 / 5063
• HGNCID: 8592
• Length: 580
• Species: Homo sapiens
• Sequence 2: NP_001024377.1
• Gene: pak-1 / 180873
• WormBaseID: WBGene00003911
• Length: 572
• Species: Caenorhabditis elegans
• Alignment Length: 619
• Identity: 319/619 - (51%)
• Similarity: 390/619 - (63%)
• Gaps: 103/619 - (16%)

Human     8 EEKPPAPPLRMNSN-NRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEK--ERPE 69
            :|||||||:|.:|: .|::..:  ..||||..||...||..:.:.|.    |.||.|::  |:|.
 Worm     8 DEKPPAPPIRFSSSATRENQVV--GLKPLPKEPEATKKKKTMPNPFM----KKNKDKKEASEKPV 66

Human    70 ISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMPDLYGSQMCPGKLPEGIPEQW 134
            ||.||:||||||||:|..|||||                                    |:||.|
 Worm    67 ISRPSNFEHTIHVGYDPKTGEFT------------------------------------GMPEAW 95

Human   135 ARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMS----------------------FT 177
            ||||..|.|:|.||::|||||||.||:|...|: :.||::.                      ::
 Worm    96 ARLLTDSQISKQEQQQNPQAVLDALKYYTQGES-SGQKWLQYDMMFIDDAPSRTPSYGLKPQPYS 159

Human   178 SGDKSAHGY-----IAAHPSSTKTAS----EPPLAPPVSEEEDEEEEEEEDENEPPPV------- 226
            :.....||.     ...:|.:|.|:|    .....||.:...:|..........||||
 Worm   160 TSSLPYHGNKIQDPRKMNPMTTSTSSAGYNSKQGVPPTTFSVNENRSSMPPSYAPPPVPHGETPA 224

Human   227 ------IAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDE 285
                  |..||..|.||||:...|          |...|...........|.   |:.|.||||.
 Worm   225 DIVPPAIPDRPARTLSIYTKPKEE----------EEKIPDLSKGQFGVQARG---QKAKKKMTDA 276

Human   286 EILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEI 350
            |:|.|||:|||:|:|.:||.:.:|||.||||:||||::|:|..|||||||||:.|||||||||||
 Worm   277 EVLTKLRTIVSIGNPDRKYRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEI 341

Human   351 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLH 415
            |||||||:.|||||||||||.|||||||||||||||||||||..|::|.|||||||.||||:|||
 Worm   342 LVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLH 406

Human   416 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 480
            |..|||||||||||||||||||||||||||||::|||.||:|||||||||||||||||.||||||
 Worm   407 SRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVD 471

Human   481 IWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGS 545
            :|||||||||||||||||||||||||:|||||||.|:....:.::.:|:||::..||:.|:.|.|
 Worm   472 VWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWS 536

Human   546 AKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSS 579
            |.:||.||||:.||||:||..||:|||::|..:|
 Worm   537 ASQLLTHPFLRCAKPLASLYYLIVAAKKSIAEAS 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAK3	NP_001121640.1	PBD	69..162	CDD:307091	40/92 (43%)
		STKc_PAK3	284..580	CDD:132987	220/296 (74%)
pak-1	NP_001024377.1	PBD	66..121	CDD:279166	38/90 (42%)
		PKc_like	287..547	CDD:304357	198/259 (76%)
		S_TKc	295..546	CDD:214567	193/250 (77%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	400	1.000	Domainoid score	I411
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	563	1.000	Inparanoid score	I645
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52925
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	1	1.000	-	-		otm15427
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1405
SonicParanoid	1	1.000	-	-		X799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010