DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PAK2 and Pak3

DIOPT Version :9

Sequence 1:NP_002568.2 Gene:PAK2 / 5062 HGNCID:8591 Length:524 Species:Homo sapiens
Sequence 2:NP_001262638.1 Gene:Pak3 / 41995 FlyBaseID:FBgn0044826 Length:583 Species:Drosophila melanogaster


Alignment Length:555 Identity:232/555 - (41%)
Similarity:313/555 - (56%) Gaps:109/555 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    73 EISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQ 137
            ||..|::|:...||..:..||:..|:|..|.||: .|.||:.||.|||.|....:|:|:.:..|:
  Fly    19 EIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLM-NSQITRDEQDKNPDAAYHAVKYYNYSIKKK 82

Human   138 KYLSFTP----------------------------PEK---DGFPSGTPALNAKG---------- 161
            :...|.|                            |||   ||..:.|...::.|          
  Fly    83 ENEVFKPFITEDVIHEESKEIENYVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNS 147

Human   162 ---------TEAPAVVTEEEDDDEET--------------APPV--------------IAPRP-- 187
                     :..|....||...:.:|              .|||              |.|:|  
  Fly   148 SSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRV 212

Human   188 ----------------DHTKSIYTRSVIDPVPAPVG------DSHVDGAAKSLDKQKKKTKMTDE 230
                            |:...|.|.::|  :...||      |.:.|.......|:|:..| ||.
  Fly   213 TQKFSRTSDIRRDEDSDNQHKINTDTII--IKPAVGAQDAGADDNPDETILRRSKEKRAQK-TDA 274

Human   231 EIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEI 295
            ||..:||.|.:..||:::|...:::|:||||.||.|.|:....:||:|.|:::.|..|:||:.||
  Fly   275 EIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEI 339

Human   296 LVMKELKNPNIVNFLDSYLV--GDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEF 358
            .|:|:..:.|:|||||:||:  .|:|:|||||:.||.||||||||.|.|.|||.||||.|.|:.|
  Fly   340 RVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISF 404

Human   359 LHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPK 423
            |||..:||||||||||||||:||||:|||||||.|..:: ||.|||||||||||||||||.||.|
  Fly   405 LHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDE-KRQTMVGTPYWMAPEVVTRKKYGKK 468

Human   424 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKR 488
            |||||:|||||||:||:||||.|.|||||||||.||.|::::.:||||..:|||:|||:::|::|
  Fly   469 VDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRR 533

Human   489 GSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSN 523
            .:|.|||.||||.....:.:|.|.|.|||:.::.|
  Fly   534 ATADELLSHPFLNDCSEVKALVPNIKAAKKVLRRN 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PAK2NP_002568.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..81 3/7 (43%)
Autoregulatory region. /evidence=ECO:0000250 69..137 24/63 (38%)
GTPase-binding. /evidence=ECO:0000250 69..112 14/38 (37%)
PBD 73..130 CDD:307091 23/56 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..164 8/70 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..188 9/64 (14%)
STKc_PAK2 229..524 CDD:132986 176/297 (59%)
Nuclear localization signal 245..251 2/5 (40%)
Pak3NP_001262638.1 PBD 19..73 CDD:279166 22/54 (41%)
PKc_like 288..545 CDD:304357 161/257 (63%)
S_TKc 293..545 CDD:214567 159/252 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0578
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D425477at33208
OrthoFinder 1 1.000 - - FOG0000763
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100484
Panther 1 1.100 - - O PTHR48015
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.820

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