DRSC/TRiP Functional Genomics Resources

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Protein Alignment PAK2 and hpo

DIOPT Version :10

Sequence 1:NP_002568.2 Gene:PAK2 / 5062 HGNCID:8591 Length:524 Species:Homo sapiens
Sequence 2:NP_611427.1 Gene:hpo / 37247 FlyBaseID:FBgn0261456 Length:669 Species:Drosophila melanogaster


Alignment Length:307 Identity:113/307 - (36%)
Similarity:183/307 - (59%) Gaps:16/307 - (5%)


- Green bases have known domain annotations that are detailed below.


Human   223 KKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPK 287
            |..|:::|.:::         .|:|.:....|:|:|:.|:|:.|........||||.:.::....
  Fly    25 KLKKLSEESLLQ---------PPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLH 80

Human   288 KELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDV--VTETCMDEAQIAAVCR 350
            :  ||.||.:|::..:|.:|.:..||....:|::.|||...||::|:  :.:..:.|.:||.:..
  Fly    81 E--IIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILS 143

Human   351 ECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV 415
            :.||.|.:||..:.||||||:.|:||..||..||.|||...|:|...:||:|::|||:||||||:
  Fly   144 DTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 208

Human   416 TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRC 480
            ....|....|||||||.|:||.||:|||...:|:||:::|.....|..:.|::.|..|.||:::|
  Fly   209 EEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKC 273

Human   481 LEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLI---MAAKEAMKSNR 524
            |..:.:.|.:|.|||:|.|::.||..|.|.|::   .|.:|..::||
  Fly   274 LVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQRANR 320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PAK2NP_002568.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..81
Autoregulatory region. /evidence=ECO:0000250|UniProtKB:Q13153 69..137
GTPase-binding. /evidence=ECO:0000250|UniProtKB:Q13153 69..112
PBD 73..130 CDD:395634
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..164
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..188
STKc_PAK2 229..524 CDD:132986 109/299 (36%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:12853446 245..251 2/5 (40%)
hpoNP_611427.1 STKc_MST1_2 38..293 CDD:132943 100/256 (39%)
SARAH_Hpo 606..661 CDD:439183
Blue background indicates that the domain is not in the aligned region.

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