DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAK2 and hpo

DIOPT Version :9

Sequence 1:	NP_002568.2	Gene:	PAK2 / 5062	HGNCID:	8591	Length:	524	Species:	Homo sapiens
Sequence 2:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	307	Identity:	113/307 - (36%)
Similarity:	183/307 - (59%)	Gaps:	16/307 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   223 KKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPK 287
            |..|:::|.:::         .|:|.:....|:|:|:.|:|:.|........||||.:.::....
  Fly    25 KLKKLSEESLLQ---------PPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLH 80

Human   288 KELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDV--VTETCMDEAQIAAVCR 350
            :  ||.||.:|::..:|.:|.:..||....:|::.|||...||::|:  :.:..:.|.:||.:..
  Fly    81 E--IIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILS 143

Human   351 ECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV 415
            :.||.|.:||..:.||||||:.|:||..||..||.|||...|:|...:||:|::|||:||||||:
  Fly   144 DTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 208

Human   416 TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRC 480
            ....|....|||||||.|:||.||:|||...:|:||:::|.....|..:.|::.|..|.||:::|
  Fly   209 EEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKC 273

Human   481 LEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLI---MAAKEAMKSNR 524
            |..:.:.|.:|.|||:|.|::.||..|.|.|::   .|.:|..::||
  Fly   274 LVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQRANR 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAK2	NP_002568.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81
		Autoregulatory region. /evidence=ECO:0000250	69..137
		GTPase-binding. /evidence=ECO:0000250	69..112
		PBD	73..130	CDD:307091
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..164
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..188
		STKc_PAK2	229..524	CDD:132986	109/299 (36%)
		Nuclear localization signal	245..251		2/5 (40%)
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	100/256 (39%)
		S_TKc	42..293	CDD:214567	98/252 (39%)
		Mst1_SARAH	608..655	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910