Protein Alignment ATP6V0A4 and Vha100-4

DIOPT Version :10

• Sequence 1: NP_065683.2
• Gene: ATP6V0A4 / 50617
• HGNCID: 866
• Length: 840
• Species: Homo sapiens
• Sequence 2: NP_650720.1
• Gene: Vha100-4 / 42214
• FlyBaseID: FBgn0038613
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 856
• Identity: 402/856 - (46%)
• Similarity: 562/856 - (65%)
• Gaps: 56/856 - (6%)

Human     3 SVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERILRF 67
            |:||||.|.|.|::||.||||..:|.|||:|.|||:|||..:|:.||||:.|||||:.|||.:|:
  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79

Human    68 LEDEMQNE--IVVQLLEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTELKYL 130
            :..|:..|  .|:.|::..|..|.|||:|.||..|||.|.|:.|...|...|:.|:|||:|:..:
  Fly    80 VTAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQV 144

Human   131 LKKTQDFFETETNLADDFFTEDTSGLLELKAV-----PAYMTGKLGFIAGVINRERMASFERLLW 190
            |::|           |.||::..|...:|..:     |....|.|||:||||:|||..:|||:||
  Fly   145 LERT-----------DQFFSDQESHNFDLNKMGTHRDPEKSNGHLGFVAGVISREREYAFERMLW 198

Human   191 RICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPAVE 255
            ||.||||:::..::|..|.||.|...:.|::|::|:||:||:.:|:|:|.||.|.:||||....|
  Fly   199 RISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSSHSE 263

Human   256 RREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQQC 320
            |:||:::|..|||||..:|.||..||..:||.|.....:|...|:|||.:||.||:.|:|:..:|
  Fly   264 RQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLGSKC 328

Human   321 VIAEIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGV 385
            :|.|.|.|..:...::.||..|....||::...:..:.:|..|||..||||||.||||::||||:
  Fly   329 LIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDAYGI 393

Human   386 GSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFHGRY 450
            ..|||:||..||.|||||||||||||.||||::.|..|||:::|:| ||:|...||||.||.|||
  Fly   394 AGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKR-LSKKRGGEIWNIFFAGRY 457

Human   451 LILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLYLQLDPAIP--GVY 513
            :|:|||:|::|||..|||.||||:|:||:.|.       ..:|...:..:..|||:|::.  ||
  Fly   458 IIMLMGLFAMYTGFHYNDIFSKSINVFGTRWV-------NVYNRTTVLTNPTLQLNPSVATRGV- 514

Human   514 FGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIP 578
                ||.||||||..||||:.|||:||||:|:|.|::.|||||.:|:.|.::|::...|||||:|
  Fly   515 ----YPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFVP 575

Human   579 EMIFILCLFGYLVFMIIFKWCCF----DVHVSQH--APSILIHFINMFLFNYSDS---SNAPLYK 634
            :::|:|.:|||:.||:.:||..:    ||.....  |||:||.||:|.||....:   .:..::.
  Fly   576 QVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDVNMFP 640

Human   635 HQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQEDATENIEGDSSSPSSRSGQR- 698
            .|:.::..|:|:||:.:||:||.||..::...|..........::..|.||       ..:|:.
  Fly   641 IQKNLEMIFLVVALLCIPWILLGKPLYIKYQRRNRPAGPVEEVDEIVEKIE-------VTTGKEI 698

Human   699 ---TSADTHGALDDHGEEFN--FGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVL 758
               ..|:.|.: ..|.||.:  ..::::|||||||||.|..||:|||||||||||||||||||||
  Fly   699 IITEVAEAHES-GGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVL 762

Human   759 WTMVMNSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGDGY 823
            ||||:..|||..|:.|.:|:|.||||:...|:||:::|||||||||.||||||||.:|||||:||
  Fly   763 WTMVLAMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNGY 827

Human   824 KFSPFSFKHIL 834
            .|:|||||.||
  Fly   828 PFTPFSFKDIL 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V0A4	NP_065683.2	V_ATPase_I	27..830	CDD:460232	383/826 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..704		5/32 (16%)
Vha100-4	NP_650720.1	V_ATPase_I	39..834	CDD:460232	383/826 (46%)