Protein Alignment ATP6V0A4 and Vha100-5

DIOPT Version :10

• Sequence 1: NP_065683.2
• Gene: ATP6V0A4 / 50617
• HGNCID: 866
• Length: 840
• Species: Homo sapiens
• Sequence 2: NP_609515.1
• Gene: Vha100-5 / 34587
• FlyBaseID: FBgn0032373
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 860
• Identity: 418/860 - (48%)
• Similarity: 575/860 - (66%)
• Gaps: 66/860 - (7%)

Human     1 MVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERIL 65
            |..:||||:|.|.|||:|.||||..:|||||.|.|||:|||..|::||||:|||||||:.:||.|
  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65

Human    66 RFLEDEM-QNEIVVQLL--EKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTEL 127
            |::|.|| ::|:.:.:|  |:.|:.|.|||::.||..|||.:.||:|.:.|..:|..:|..:.||
  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130

Human   128 KYLLKKTQDFFETETNLADD----FFTEDTSGLLELKAVP-AYMTGKLGFIAGVINRERMASFER 187
            ||:|:.|:.||..:..:..|    ...||.:.|      | |...|:|.|:||||..||..||||
  Fly   131 KYVLENTEGFFSDQEVINLDVNRKLDPEDPANL------PGAAQRGQLAFVAGVIKLERFFSFER 189

Human   188 LLWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEP 252
            :||||.|||::|:.:::|..:.|..|...:.|.:|:.|:|||||:|:|||:|.|:.|.|||||..
  Fly   190 MLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCPSS 254

Human   253 AVERREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVT 317
            ..||:||::.||||||||..|::|:..||.|:|..|:.:...|.|.|:||||:|||||..|.|||
  Fly   255 HAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPDVT 319

Human   318 QQCVIAEIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDA 382
            .:|:|.|.|.|..|.:.::.||.:..::|.||:...|..:::...|||:.||||||.||||:||:
  Fly   320 GKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLVDS 384

Human   383 YGVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFH 447
            ||:.||||:|||.|..|||||||||||||.|||.::||.|.|:|:.|::|.|.|  .||:|.||.
  Fly   385 YGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQLSSIK--EEIFNIFFG 447

Human   448 GRYLILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESL-YLQLDPAIPG 511
            |||:|.||||||||||.||||.||||:|||||:|.:     |.|.:. |.:|:| |:.|.|. ..
  Fly   448 GRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHM-----NYTRDV-VEDENLKYITLRPN-DT 505

Human   512 VYFGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQF 576
            ||  ..||||:||||.||.||:.|||::|||:|:|:|::.|:|||.:|:.|..|:::..:|.|:|
  Fly   506 VY--KTYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLEF 568

Human   577 IPEMIFILCLFGYLVFMIIFKWCCFDVHVS-----QHAPSILIHFINMFLFNYSDSSNAP----- 631
            :|:::|:|.||||:|||:.|||..::..|.     ..||||||.||||.|   ..|.:.|
  Fly   569 LPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMIL---QGSQDTPEPCKE 630

Human   632 -LYKHQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQEDATENIEGDSSSPSSRS 695
             ::..|:.:|..|||:|:|.:|||||.||..:....:.:                 .:..|..:|
  Fly   631 FMFDGQKSIQQVFVVVAIICIPWMLLGKPLYIMIKRKTN-----------------GAPPPKPQS 678

Human   696 GQRTSADTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWT 760
            |        |. :.|||:...|::|:|||||||||.|..:|:||||||||||||||||||||||.
  Fly   679 G--------GG-EGHGEDDEMGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVLWN 734

Human   761 MVMNSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGDGYKF 825
            ||.:.|.:...:.|.:.:::.|..:|:|||.||:::||||||||.||||||||.:|||.|.||.|
  Fly   735 MVFSMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAF 799

Human   826 SPFSFKHILDGTAEE 840
            .||:||.|||.:.::
  Fly   800 EPFAFKTILDVSEDD 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V0A4	NP_065683.2	V_ATPase_I	27..830	CDD:460232	398/822 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..704		3/28 (11%)
Vha100-5	NP_609515.1	V_ATPase_I	27..804	CDD:460232	398/822 (48%)