Protein Alignment ATP6V0A4 and atp6v0a4

DIOPT Version :10

• Sequence 1: NP_065683.2
• Gene: ATP6V0A4 / 50617
• HGNCID: 866
• Length: 840
• Species: Homo sapiens
• Sequence 2: NP_001107162.1
• Gene: atp6v0a4 / 100135019
• XenbaseID: XB-GENE-493197
• Length: 846
• Species: Xenopus tropicalis
• Alignment Length: 846
• Identity: 637/846 - (75%)
• Similarity: 733/846 - (86%)
• Gaps: 6/846 - (0%)

Human     1 MVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERIL 65
            |.|:||||||.|:||.|||||.|||:|||||||||||:|||.:||||||:|||||||||::||||
 Frog     1 MASLFRSEEMSLTQLILQVEAGYCCIAELGELGLVQFRDLNASVNSFQRRFVNEVRRCENMERIL 65

Human    66 RFLEDEMQNE-IVVQLLEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTELKY 129
            ||||.||.|: |.::..||.|.||||||||.||||||||||||||.|:|||||||:||||||||:
 Frog    66 RFLESEMVNDKIKIRTPEKLPQTPLPREMIDLETVLEKLEGELQEVNRNQQALKQNFLELTELKH 130

Human   130 LLKKTQDFFETETNLADDFFTEDTSGLLELKAVP-AYMTGKLGFIAGVINRERMASFERLLWRIC 193
            ||||||||||.|.||.||||:||||.||||:.:| |...|||||.||||||||||:|||||||:|
 Frog   131 LLKKTQDFFEAEANLPDDFFSEDTSSLLELRTIPSAAAAGKLGFTAGVINRERMATFERLLWRVC 195

Human   194 RGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPAVERRE 258
            |||:|||::|:|..|||||||||::||:|||||||:||:.|||||||||:||||||||.|.||:|
 Frog   196 RGNIYLKYTELDTALEDPVTKEEVKKNVFIIFYQGDQLKLKIKKICDGFKATVYPCPESATERKE 260

Human   259 MLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQQCVIA 323
            |:..||.|:|||.||||||||||||:|.|||.:..||.|||:|||||||:||:||||||||||||
 Frog   261 MVADVNTRIEDLNTVITQTESHRQRVLLEAAQSLCSWGIKVKKMKAVYHVLNLCNIDVTQQCVIA 325

Human   324 EIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSY 388
            |||.|:||..:||:||.:|||.|||::|||:|.:.||..|||||||||||:||||||:|||||||
 Frog   326 EIWCPIADKEQIKQALHRGMERSGSTIAPILTNISSKLDPPTFNRTNKFTSGFQNIVNAYGVGSY 390

Human   389 REINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFHGRYLIL 453
            ||:||.|||||||||||||||||||||:|||..||||:|||::||:.|||||||||||.||||||
 Frog   391 REMNPTPYTIITFPFLFAVMFGDCGHGSVMLGFALWMVLNEKQLLASKTDNEIWNTFFGGRYLIL 455

Human   454 LMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLYLQLDPAIPGVYFGNPY 518
            ||.|||||||.|||||||||.:||||||.|:|||.|.|||.:::.:.|.||||||:||||.||||
 Frog   456 LMSIFSIYTGFIYNDCFSKSFDIFGSSWRVRPMFINKTWNDNLVHQGLQLQLDPAVPGVYSGNPY 520

Human   519 PFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIPEMIFI 583
            |||||||||:|.|||||||||||||||::||.||||||:|.|.|||.|:|.:||||||:||||||
 Frog   521 PFGIDPIWNIAQNKLTFLNSYKMKMSVVMGITQMVFGVMLGLLNHINFKRPINIILQFVPEMIFI 585

Human   584 LCLFGYLVFMIIFKWCCFDVHVSQHAPSILIHFINMFLFNYSDSSNAPLYKHQQEVQSFFVVMAL 648
            :|||||||||||||||.:|||.||.||||||||||||||||||.:|||||:||:|||:|.|:.||
 Frog   586 ICLFGYLVFMIIFKWCKYDVHSSQGAPSILIHFINMFLFNYSDPTNAPLYEHQKEVQTFLVIFAL 650

Human   649 ISVPWMLLIKPFILRASHRKSQ--LQASRIQEDATE--NIEGDSSSPSSRSGQRTSADTHGALDD 709
            |:||||||||||:|||:|.|:|  ||:|...||..|  ::|...::..|:..:....|..|...:
 Frog   651 IAVPWMLLIKPFVLRANHLKAQRMLQSSSGPEDHAELTDVENAHANHKSKKEEHGGGDHGGGHGE 715

Human   710 HGEEFNFGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVMNSGLQTRGWGG 774
            |||||:|||:||||||||||||||||||||||||||||||||||||||||||||:.||...|:||
 Frog   716 HGEEFDFGDIFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVMHQGLSIGGYGG 780

Human   775 IVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGDGYKFSPFSFKHILDGTAE 839
            ::|||||||.||||||||||:|||||||||||||||||||||||.|.|:.||||||:.||:||..
 Frog   781 LIGVFIIFAAFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYAGTGHLFSPFSFQSILEGTDN 845

Human   840 E 840
            |
 Frog   846 E 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V0A4	NP_065683.2	V_ATPase_I	27..830	CDD:460232	611/808 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..704		6/30 (20%)
atp6v0a4	NP_001107162.1	V_ATPase_I	27..836	CDD:460232	611/808 (76%)