Protein Alignment UBQLN3 and DSK2

DIOPT Version :10

• Sequence 1: NP_059509.1
• Gene: UBQLN3 / 50613
• HGNCID: 12510
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_014003.1
• Gene: DSK2 / 855319
• SGDID: S000004889
• Length: 373
• Species: Saccharomyces cerevisiae
• Alignment Length: 637
• Identity: 123/637 - (19%)
• Similarity: 187/637 - (29%)
• Gaps: 277/637 - (43%)

Human    22 IKVTVKTPKDKEDFSVTDTCTIQQLKEEISQRFKAHPDQLVLIFAGKILKDPDSLAQCGVRDGLT 86
            :.:.:|:.:||.:.:|....|:.|.||.|::..........||::||||||..::....::||.:
Yeast     3 LNIHIKSGQDKWEVNVAPESTVLQFKEAINKANGIPVANQRLIYSGKILKDDQTVESYHIQDGHS 67

Human    87 VHLVIKRQHRAMGNECPAASVPTQGPSPGSLPQPSSIYPADGPPAFSLGLLTGLSRL----GLAY 147
            ||||..:......:...|.:....|.:.|:          ...|..|.|...|.:.|    ...|
Yeast    68 VHLVKSQPKPQTASAAGANNATATGAAAGT----------GATPNMSSGQSAGFNPLADLTSARY 122

Human   148 RGFPDQPSSLMRQHVSVPEFVTQLIDDPFIP--GLLSNTGLVRQLVLDNPHMQQLIQHNPEIGHI 210
            .|:.:.||:                 |.|.|  |.|:|         |:.:..:|::       :
Yeast   123 AGYLNMPSA-----------------DMFGPDGGALNN---------DSNNQDELLR-------M 154

Human   211 LNNPEIMRQTLEFLRNPAMMQEMIRSQDRVLSNLESIPGGYNVLCTMYTDIMDPMLNAVQEQFGG 275
            :.||....|..|.|.||.|:..||:|                          :|.|.|:
Yeast   155 MENPIFQSQMNEMLSNPQMLDFMIQS--------------------------NPQLQAM------ 187

Human   276 NPFATATTDNATTTTSQPSRMENCDPLPNPWTSTHGGSGSRQGRQDGDQDAPDIRNRFPNFLGII 340
                                                |..:||..|.            |.|
Yeast   188 ------------------------------------GPQARQMLQS------------PMF---- 200

Human   341 RLYDYLQQLHENPQSLGTYLQGTASALSQSQEPPPSVNRVPPSSPSSQEPGSGQPLPEESVAIKG 405
                  :|:..||..:...:|     .::..:|...:...  ...:|..|..|...|||.
Yeast   201 ------RQMLTNPDMIRQSMQ-----FARMMDPNAGMGSA--GGAASAFPAPGGDAPEEG----- 247

Human   406 RSSCPAFLRYPTENSTGQGGDQDGAGKSSTGHSTNLPDLVSGLGDSANRVPFAPLSFSPTAAIPG 470
                      ...|:|......:.||   |...||     :|...:||  |||.|
Yeast   248 ----------SNTNTTSSSNTGNNAG---TNAGTN-----AGANTAAN--PFASL---------- 282

Human   471 IPEPPWLPSPAYPRSLRPDGMNPAPQLQDEIQPQLPLLMHLQAAMANPRALQALRQIEQGLQVLA 535
                                :|||                     .||.|
Yeast   283 --------------------LNPA---------------------LNPFA--------------- 291

Human   536 TEAPRLLLWFMPCLAGTGSVAGGIESREDPLMSEDPLPNPPPEVFPALDSAELGFLSPPFLHMLQ 600
                         .||..:..|                      .||.|.|.|..:..|.:...|
Yeast   292 -------------NAGNAASTG----------------------MPAFDPALLASMFQPPVQASQ 321

Human   601 DLVSTNPQQLQPEAHFQVQLEQLRSMGFLNREANLQALIATGGDVDAAVEKL 652
             ...|.|    ||..::.||.||..|||.:.:.|:.||..:||.|..|::.|
Yeast   322 -AEDTRP----PEERYEHQLRQLNDMGFFDFDRNVAALRRSGGSVQGALDSL 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN3	NP_059509.1	Ubl_PLICs	20..92	CDD:340506	23/69 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..124		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	277..330		4/52 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..399		5/34 (15%)
		PHA03378	<368..627	CDD:223065	45/258 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	412..447		7/34 (21%)
		UBA_PLICs	615..654	CDD:270582	15/38 (39%)
DSK2	NP_014003.1	Ubl_Dsk2p_like	3..74	CDD:340523	23/70 (33%)
		STI1	149..185	CDD:128966	13/68 (19%)
		UBA_Dsk2p_like	328..369	CDD:270509	17/41 (41%)