Protein Alignment UBQLN3 and ubqln1

DIOPT Version :10

• Sequence 1: NP_059509.1
• Gene: UBQLN3 / 50613
• HGNCID: 12510
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_989221.1
• Gene: ubqln1 / 394829
• XenbaseID: XB-GENE-986025
• Length: 564
• Species: Xenopus tropicalis
• Alignment Length: 676
• Identity: 278/676 - (41%)
• Similarity: 357/676 - (52%)
• Gaps: 154/676 - (22%)

Human     9 PQGSPAPVQDP-HLIKVTVKTPKDKEDFSVTDTCTIQQLKEEISQRFKAHPDQLVLIFAGKILKD 72
            |..|.....|| .:|||||||||:||:|:|.:..:|::.||:||:|||:..:|||||||||||||
 Frog     5 PSSSTPSSSDPARIIKVTVKTPKEKEEFAVPENSSIREFKEDISKRFKSSTEQLVLIFAGKILKD 69

Human    73 PDSLAQCGVRDGLTVHLVIKRQHRAM-GNECPAASVPTQGPSPGSLPQPSSIYPADGPP--AFSL 134
            .|:|:|.|:.||||||||||.|:|:. .....|:|..|...:..:....::.....|.|  ...|
 Frog    70 QDTLSQHGIHDGLTVHLVIKTQNRSQAATASQASSSSTSATNSTTSSSSTTTTTTTGTPLGLGGL 134

Human   135 GLLTGLSRLGLAYRGFPDQPSSLMRQHVSVPEFVTQLIDDPFIPGLLSNTGLVRQLVLDNPHMQQ 199
            |.|.|||.||:....|.:..|.:.:|.:|.||.:.|::::||:..:|||..|:.||::.||.|||
 Frog   135 GGLAGLSSLGMNASNFSELQSQMQQQLMSNPEMMVQIMENPFVQSMLSNPDLMSQLIMANPQMQQ 199

Human   200 LIQHNPEIGHILNNPEIMRQTLEFLRNPAMMQEMIRSQDRVLSNLESIPGGYNVLCTMYTDIMDP 264
            |||.||||.|:||||:|||||||..|||||||||:|:|||.||||||||||||.|..|||||.:|
 Frog   200 LIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEP 264

Human   265 MLNAVQEQFGGNPFATATTDNATTTTSQPSRMENCDPLPNPW---TSTHG--GSGSRQG-RQDGD 323
            ||||.||||||||||:..: ||:...:||||.||.|||||||   :||.|  .:||..| ...|.
 Frog   265 MLNAAQEQFGGNPFASLVS-NASNAGNQPSRTENRDPLPNPWAPPSSTAGSTSTGSTTGANSTGS 328

Human   324 QDAPDIRNRFPNF-LGIIR---LYDYLQQLHENPQSL-----GTYLQGTASALSQSQEPPPSVNR 379
            .......:..||. .|:..   :...:||:.||||.:     ..|::....:|||:.|
 Frog   329 STTTTTSSTLPNLGAGMFNTPGMQSLMQQITENPQLMQNMLSAPYMRSMMQSLSQNPE------- 386

Human   380 VPPSSPSSQEPGSGQPLPEESVAIKGRSSCPAFLRYPTENSTGQGGDQDGAGKSSTGHSTNLPDL 444
                                 :|.:...:.|.|
 Frog   387 ---------------------LAAQVMQNNPLF-------------------------------- 398

Human   445 VSGLGDSANRVPFAPLSFSPTAAIPGIPEPPWLPSPAYPRSLRPDGMNPAPQLQDEIQPQLP-LL 508
                  |.|                                         ||||::::.||| .|
 Frog   399 ------SGN-----------------------------------------PQLQEQMRQQLPFFL 416

Human   509 MHLQ-----AAMANPRALQALRQIEQGLQVLATEAPRLLLWFMPCLAGTGSVAGGIESREDPLMS 568
            ..:|     :||:||||:|||.||:||||.||||||.|:....|...|.||          |..|
 Frog   417 QQMQNPETLSAMSNPRAMQALLQIQQGLQTLATEAPSLMPRTNPPFGGLGS----------PNSS 471

Human   569 EDPLPNPPPEVFPALDSAELGFLSPP----FL-HMLQDLVSTNPQQL--QPEAHFQVQLEQLRSM 626
                |...|...|..:|:.|..||.|    |: .|||.|...|||..  .||..||.|||||.:|
 Frog   472 ----PASVPSSAPTENSSPLSGLSEPGHQQFIQQMLQALSGANPQNQNPNPEVRFQPQLEQLSAM 532

Human   627 GFLNREANLQALIATGGDVDAAVEKL 652
            ||||||||||||||||||::||:|:|
 Frog   533 GFLNREANLQALIATGGDINAAIERL 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN3	NP_059509.1	Ubl_PLICs	20..92	CDD:340506	46/71 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..124		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	277..330		25/58 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..399		4/34 (12%)
		PHA03378	<368..627	CDD:223065	70/271 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	412..447		1/34 (3%)
		UBA_PLICs	615..654	CDD:270582	30/38 (79%)
ubqln1	NP_989221.1	Ubl_PLICs	17..89	CDD:340506	46/71 (65%)
		STI1	194..238	CDD:450205	34/43 (79%)
		STI1	364..396	CDD:128966	6/59 (10%)
		UBA_PLICs	521..560	CDD:270582	30/38 (79%)