DRSC/TRiP Functional Genomics Resources

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Protein Alignment UBQLN3 and ubqln4

DIOPT Version :10

Sequence 1:NP_059509.1 Gene:UBQLN3 / 50613 HGNCID:12510 Length:655 Species:Homo sapiens
Sequence 2:NP_998521.2 Gene:ubqln4 / 334337 ZFINID:ZDB-GENE-030131-6269 Length:599 Species:Danio rerio


Alignment Length:673 Identity:269/673 - (39%)
Similarity:355/673 - (52%) Gaps:145/673 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    21 LIKVTVKTPKDKEDFSVTDTCTIQQLKEEISQRFKAHPDQLVLIFAGKILKDPDSLAQCGVRDGL 85
            :||||||||||||:.::.:..::.|.|||||:||||..||||||||||||||.|:|.|.|::|||
Zfish    25 IIKVTVKTPKDKEEIAIAEDASVAQFKEEISKRFKAKQDQLVLIFAGKILKDGDTLGQHGIKDGL 89

Human    86 TVHLVIKRQHRAMG---NECPAASVPTQGPSPGS--------------LPQPSSIYPADGPPAFS 133
            |||||||...:..|   ::..|:|.|  |||.||              .||.|...|....||..
Zfish    90 TVHLVIKTAQKTSGAGSSQTSASSGP--GPSQGSPSGTDTPSPAGNLGTPQGSGPSPTPSQPANI 152

Human   134 L---GLLTGLSRLGLAYRGFPDQPSSLMRQHVSVPEFVTQLIDDPFIPGLLSNTGLVRQLVLDNP 195
            |   |.|:|||.||:....|.:....:.||.:|.||.::|::::|.:..::||..|:||:::.||
Zfish   153 LAGFGDLSGLSNLGMGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQSMMSNPDLMRQMIMANP 217

Human   196 HMQQLIQHNPEIGHILNNPEIMRQTLEFLRNPAMMQEMIRSQDRVLSNLESIPGGYNVLCTMYTD 260
            .||||::.||||.|:|||||:||||:|..|||||||||:|:|||.||||||||||||.|..||||
Zfish   218 QMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTD 282

Human   261 IMDPMLNAVQEQFGGNPFATATTDNATTTTSQPSRMENCDPLPNPWTSTHGGSGSRQGRQDGDQD 325
            |.:||.:|.:||||.||| :|...|.....:||||.||.:||||||                  .
Zfish   283 IQEPMFSAAREQFGNNPF-SALGGNGENPGTQPSRTENREPLPNPW------------------G 328

Human   326 APDIRNRFPNFLGIIRLYDYLQQLHENPQSLGTYLQGTASALSQSQEPPPSVNRVPPSSPSSQEP 390
            .||                                 ||||..|.......|      |:.||..|
Zfish   329 PPD---------------------------------GTASTTSSGTPTTTS------STTSSTTP 354

Human   391 GSGQPLPEESVAIKGRSSCPAFLRYPTENSTGQGGDQDGAGKSSTGHSTNLPDLVSGLGDSANRV 455
            ....||        |.||          ::.|.|.......:|.....:..|.|:..:..:    
Zfish   355 SVSNPL--------GISS----------SNLGNGMFNSPGMQSLMQQISENPQLMQNMISA---- 397

Human   456 PFAPLSFSPTAAIPGIPEPPWLPSPAYPRSLRPDGMNPAPQLQDEIQPQLPL-LMHLQ-----AA 514
            |:........|..|.:.....:.:|.:..:         ||||::::.|||: |..:|     :.
Zfish   398 PYMRTMMQSLAQNPDVASQVLMNNPLFAGN---------PQLQEQMRQQLPVFLQQMQNPEALSV 453

Human   515 MANPRALQALRQIEQGLQVLATEAPRLLLWFMPCLAGTGSVAGGIESREDPL-MSEDPLP----- 573
            |.||||::||.||::|||.|.||||.|    ||.| |.|.:.|||     |: |...|||     
Zfish   454 MTNPRAMRALMQIQEGLQTLQTEAPGL----MPGL-GPGGMPGGI-----PVGMPGAPLPTGVTV 508

Human   574 ---NPPPEVFPALDSAELGFLSPPFLHMLQDLV------STNPQQLQPEAHFQVQLEQLRSMGFL 629
               ||||....:..:...| .||....::|.::      |.:.|  .||..||.|||||.:|||:
Zfish   509 TPENPPPSGQGSTPTPTAG-ASPAQQQLMQQMLQMFAGGSASTQ--TPEVRFQQQLEQLSAMGFI 570

Human   630 NREANLQALIATGGDVDAAVEKL 652
            |||||||||||||||::||:|:|
Zfish   571 NREANLQALIATGGDINAAIERL 593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UBQLN3NP_059509.1 Ubl_PLICs 20..92 CDD:340506 48/70 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 102..124 11/35 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 277..330 18/52 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..399 10/34 (29%)
PHA03378 <368..627 CDD:223065 79/279 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 412..447 5/34 (15%)
UBA_PLICs 615..654 CDD:270582 29/38 (76%)
ubqln4NP_998521.2 Ubl_PLICs 25..96 CDD:340506 48/70 (69%)
rad23 26..311 CDD:273167 150/287 (52%)
UBA_PLICs 556..595 CDD:270582 29/38 (76%)

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