Protein Alignment UBQLN3 and Ubqn

DIOPT Version :10

• Sequence 1: NP_059509.1
• Gene: UBQLN3 / 50613
• HGNCID: 12510
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_608344.1
• Gene: Ubqn / 32977
• FlyBaseID: FBgn0031057
• Length: 547
• Species: Drosophila melanogaster
• Alignment Length: 686
• Identity: 223/686 - (32%)
• Similarity: 313/686 - (45%)
• Gaps: 182/686 - (26%)

Human     1 MAKGGEALPQGSPAPVQDPHLIKVTVKTPKDKEDFSVTDTCTIQQLKEEISQRFKAHPDQLVLIF 65
            ||:||.             ..|.|.|||||||:...|.:...|:..|..::|:|:|.|:||||||
  Fly     1 MAEGGS-------------KRINVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIF 52

Human    66 AGKILKDPDSLAQCGVRDGLTVHLVIKRQHRAMGNECPAASVPTQGPSPGSLPQPSSIYPADGPP 130
            ||||:||.|:|....::|.||||||||...|  .||.||........:|..|.|
  Fly    53 AGKIMKDTDTLQMHNIKDNLTVHLVIKAPTR--NNEQPARQPADVRQTPFGLNQ----------- 104

Human   131 AFSLGLLTGLSRLGLAYRGFPDQPSSLMRQHVSVPEFVTQLIDDPFIPGLLSNTGLVRQLVLDNP 195
               .|.|.|:..||.....|.|..:.:..:.::..:.:..|:|:|.:..:::|...:|||:..||
  Fly   105 ---FGGLAGMEALGAGSNTFMDLQARMQNELLNNGDMLRSLMDNPMVQQMMNNPDTMRQLITSNP 166

Human   196 HMQQLIQHNPEIGHILNNPEIMRQTLEFLRNPAMMQEMIRSQDRVLSNLESIPGGYNVLCTMYTD 260
            .|..|:|.||||.|:||||:::|||:|..|||:|:||::||.||.:|||||:||||:.|..:|.|
  Fly   167 QMHDLMQRNPEISHMLNNPDLLRQTMELARNPSMLQELMRSHDRAMSNLESVPGGYSALQRIYRD 231

Human   261 IMDPMLNAVQEQFGGNPFATATTDNATTTTSQPSR-MENCDPLPNPW-------TSTHGGSGSRQ 317
            |.:||:||..|.||.||||.......:...:.|.: .||.:||||||       ..|.||||:
  Fly   232 IQEPMMNAATESFGRNPFAGLVDGGGSGAGNNPQQGTENRNPLPNPWGGANSGTNGTVGGSGA-- 294

Human   318 GRQDGDQDAPDIRNRFP--NFLGIIRLYDYLQQLHENPQSLGTYLQGTASALSQSQEPPPSVNRV 380
            |...||         .|  |.|....:...|||:.:||            |:.|:
  Fly   295 GNPTGD---------LPPNNVLNTPAMRSLLQQMADNP------------AMMQN---------- 328

Human   381 PPSSPSSQEPGSGQPLPEESVAIKGRSSCPAFLRYPTENSTGQGGDQDGAGKSSTGHSTNLPDLV 445
                                           .|..|...|..:...||             ||:.
  Fly   329 -------------------------------LLNAPYTRSMMESMSQD-------------PDMA 349

Human   446 SGLGDSANRVPFAPLSFSPTAAIPGIPEPPWLPSPAYPRSLRPDGMNPAPQLQDEIQPQLPLLM- 509
            :.|           ||.||.                         |:..|.||::::..:|..|
  Fly   350 ARL-----------LSSSPL-------------------------MSNNPALQEQVRQMMPQFMA 378

Human   510 -----HLQAAMANPRALQALRQIEQGLQVLATEAPRLL----LWFMPCLAGTGS------VAGGI 559
                 .:...:.||.|:.|:.||:||::.|.:.||.|:    :...|..||||:      .:||.
  Fly   379 QMQNPEVMNMLTNPDAMNAILQIQQGMEQLRSAAPGLVGTLGIPPPPPGAGTGTNPASGDGSGGN 443

Human   560 E-------SREDPLMSEDPLPNPPPEVFPALDSAELGFLSPPFLHMLQDLVSTNPQQLQ-PEAHF 616
            .       |....|.:....||..|...|   :|:|  .:...:.||..: |.|....| ||..:
  Fly   444 SGASTNNVSPSSGLNAGTGTPNLAPGGGP---NAQL--FNDFMMRMLNGM-SNNADNTQPPEVRY 502

Human   617 QVQLEQLRSMGFLNREANLQALIATGGDVDAAVEKL 652
            |.|||||.:|||:||:|||||||||.||::||||:|
  Fly   503 QSQLEQLNAMGFVNRDANLQALIATFGDINAAVERL 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN3	NP_059509.1	Ubl_PLICs	20..92	CDD:340506	37/71 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..124		5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	277..330		20/60 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..399		2/34 (6%)
		PHA03378	<368..627	CDD:223065	59/282 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	412..447		7/34 (21%)
		UBA_PLICs	615..654	CDD:270582	27/38 (71%)
Ubqn	NP_608344.1	Ubl_PLICs	7..79	CDD:340506	37/71 (52%)
		PABP-1234	<233..409	CDD:130689	64/288 (22%)
		UBA_PLICs	501..537	CDD:270582	25/35 (71%)