DRSC/TRiP Functional Genomics Resources

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Protein Alignment UBQLN3 and dsk2

DIOPT Version :10

Sequence 1:NP_059509.1 Gene:UBQLN3 / 50613 HGNCID:12510 Length:655 Species:Homo sapiens
Sequence 2:NP_594159.1 Gene:dsk2 / 2542667 PomBaseID:SPAC26A3.16 Length:354 Species:Schizosaccharomyces pombe


Alignment Length:654 Identity:125/654 - (19%)
Similarity:181/654 - (27%) Gaps:330/654 - (50%)


- Green bases have known domain annotations that are detailed below.


Human    22 IKVTVKTPKDKEDFSVT--DTCTIQQLKEEISQRFKAHPDQLVLIFAGKILKDPDSLAQCGVRDG 84
            |.:|:|...|:: ::||  ...::..|||.|:.......::..||:||::|||.:||....::||
pombe     4 ISLTIKAANDQK-YAVTVDSESSVLALKEAIAPVADIEKERQRLIYAGRVLKDEESLKTYKIQDG 67

Human    85 LTVHLVIKRQHRAMGNECPAASVPTQGPSPGSLPQPSSIYPADGPPAFSLGLLTGLSRLGLAYRG 149
            .::|||     :.:|.. |||:                                           
pombe    68 HSIHLV-----KTLGQN-PAAA------------------------------------------- 83

Human   150 FPDQPSSLMRQHVSVPEFVTQLIDDPFIPGLLSNTGLVRQLVLDNPHMQQLIQHNPEIGHILNNP 214
                              .|.:.|                       ..|.:..|.:.|...|||
pombe    84 ------------------ATNVSD-----------------------RTQQVPTNIQAGQGANNP 107

Human   215 EIMRQTLEFLRNPAMMQEMIRSQDRVLSNLESIP-GGYNVLCTMYTDIMDPMLNAVQEQFGGNPF 278
                                      |:||.|.. .|:|:          ||.:|  ..||.|| 
pombe   108 --------------------------LANLTSARYAGFNI----------PMPSA--SMFGPNP- 133

Human   279 ATATTDNATTTTSQPSRMENCDPLPNPWTSTHGGSGSRQGRQDGDQDAPDIRNRFPNFLGIIRLY 343
                 :|..    .||..|..:.|.||...:.                                 
pombe   134 -----ENPV----PPSTEELANMLSNPMVQSS--------------------------------- 156

Human   344 DYLQQLHENPQSLGTYLQGTASALSQSQEPPPSVNRVPPSSPSSQEPGSGQPLPEESVAIKGRSS 408
              :.::..|||.|...:..:           |.:...||                   .::....
pombe   157 --INEMFSNPQMLDMIINSS-----------PHLRNAPP-------------------YVRQMMQ 189

Human   409 CPAFLRYPTENSTGQ--------------------GGDQDGAGKSSTGHSTNLPDLVSGLGDSAN 453
            .|.|.|..|:..|.:                    ||...|||....|.:.     :.|.|.:.|
pombe   190 SPEFRRAMTDPDTMRQMAQLHQQMGAAGIDPMSLMGGGLGGAGLGGLGGAG-----LGGFGGANN 249

Human   454 RVPFAPLSFSPTAAIPGIPEPPWLPSPAYPRSLRPDGMNPAPQLQDEIQPQLPLLMHLQAAMANP 518
                      .||.|.|          |.|    .|....|..:|:       ||.:|..|    
pombe   250 ----------ATAGIAG----------AAP----VDQTAAANTIQN-------LLNNLGGA---- 279

Human   519 RALQALRQIEQGLQVLATEAPRLLLWFMPCLAGTGSVAGGIESREDPLMSEDPLPNPPPEVFPAL 583
                   ....||..                ||.|:..||..|              ||.  ||.
pombe   280 -------GFGAGLGD----------------AGLGAGLGGAAS--------------PPA--PAQ 305

Human   584 DSAELGFLSPPFLHMLQDLVSTNPQQLQPEAHFQVQLEQLRSMGFLNREANLQALIATGGDVDAA 648
            |                    |.|    ||..:..||.||..|||::.|.|:|||..:||:|..|
pombe   306 D--------------------TRP----PEERYAEQLSQLNEMGFVDFERNVQALRRSGGNVQGA 346

Human   649 VEKL 652
            :|.|
pombe   347 IESL 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UBQLN3NP_059509.1 Ubl_PLICs 20..92 CDD:340506 24/71 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 102..124 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 277..330 8/52 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..399 3/34 (9%)
PHA03378 <368..627 CDD:223065 51/278 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 412..447 10/54 (19%)
UBA_PLICs 615..654 CDD:270582 18/38 (47%)
dsk2NP_594159.1 rad23 4..>169 CDD:273167 60/338 (18%)
Ubl_Dsk2p_like 4..74 CDD:340523 24/75 (32%)
UBA_Dsk2p_like 310..351 CDD:270509 20/41 (49%)

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