DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment UBQLN3 and ubql-1

DIOPT Version :10

Sequence 1:NP_059509.1 Gene:UBQLN3 / 50613 HGNCID:12510 Length:655 Species:Homo sapiens
Sequence 2:NP_740883.1 Gene:ubql-1 / 172434 WormBaseID:WBGene00008852 Length:502 Species:Caenorhabditis elegans


Alignment Length:648 Identity:183/648 - (28%)
Similarity:279/648 - (43%) Gaps:166/648 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    21 LIKVTVKTPKDKEDFSVTDTCTIQQLKEEISQRF-KAHPDQLVLIFAGKILKDPDSLAQCGVRDG 84
            ||||.||:|.:|.|..:....::.:||:::.... .|:.:|:.:|:.||||||.::|.|..:.||
 Worm     7 LIKVHVKSPSNKYDVEIAADASVSELKDKVLVFVPTANKEQVCIIYTGKILKDEETLTQHKIADG 71

Human    85 LTVHLVIKRQHRAMGNECPAASVPTQGPSPGSLPQPSS-IYPADGPPAFSLGLLTGLSRLGLAYR 148
            .||||||:.|.|.  ...|||:.||...:|.|.|.||| ..|.:.|               .|..
 Worm    72 HTVHLVIRNQARP--TPAPAAATPTASSAPSSNPTPSSQPNPTNNP---------------FAAM 119

Human   149 GFPDQPSSLMRQHVSVPEFVTQLIDDPFIPGLLSNTGLVRQLVLDNPHMQQLIQHNPEIGHILNN 213
            |....|:.::..    |:.:..::|:|....||.|...:|.::..||..|.||:.|||:|||||:
 Worm   120 GGMGSPADILNN----PDAMRSVMDNPITQQLLGNPEFMRTIIQSNPQFQALIERNPEVGHILND 180

Human   214 PEIMRQTLEFLRNPAMMQEMIRSQDRVLSNLESIPGGYNVLCTMYTDIMDPMLNAVQEQFGGNPF 278
            |.:||||:|.:|||.|.|||:|:.|:.:.||:.||||...|..:|.|:.:|:||:......||||
 Worm   181 PNVMRQTMEMIRNPNMFQEMMRNHDQAIRNLQGIPGGEAALERLYNDVQEPLLNSATNSLSGNPF 245

Human   279 ATATTDNATTTTSQPSRMENCDPLPNPWTS-----THGGSGSRQGRQDGDQDAPDIRNRFPNFLG 338
            |:...|.::......:..||.:.|||||.|     |:..|.:|....:...|:|.|.:       
 Worm   246 ASLRGDQSSEPRVDRAGQENNEALPNPWASNANQATNNQSNNRSADFNSLLDSPGISS------- 303

Human   339 IIRLYDYLQQLHENPQSLGTYLQGTASALSQSQEPPPSVNRVPPSSPSSQEPGSGQPLPEESVAI 403
                  .::|:..||            ::..|...|..:|.:..:  .|..||            
 Worm   304 ------LMEQMMSNP------------SMQASMFSPEVINSIRQN--MSNNPG------------ 336

Human   404 KGRSSCPAFLRYPTENSTGQGGDQDGAGKSSTGHSTNLPDLVSGLGDSANRVPFAPLSFSPTAAI 468
                                                 |.|.:.|      ::|.|          
 Worm   337 -------------------------------------LIDSIVG------QIPSA---------- 348

Human   469 PGIPEPPWLPSPAYPRSLRPDGMNPAPQLQDEIQPQLPLLMHLQA------AMANPRALQALRQI 527
                                   ...||:.:.|:...|.::::.:      ||.|||..:|.|||
 Worm   349 -----------------------RDNPQISEGIRRSFPQMLNMMSDPSVMEAMRNPRVSEAFRQI 390

Human   528 EQGLQVLATEAPRLLLWFMPCLAGTGSVAGGIESREDPLMSEDPLPNPPPEVFPALDSAELGFLS 592
            ::|...|..|||:||..|.....|.|:......:......|.:.|.:       ..:|..:|...
 Worm   391 QEGFSTLRREAPQLLNLFQAGAMGGGAFGSDANASSAGANSANGLAD-------LFNSMNMGGGR 448

Human   593 PPFLHMLQDLVSTNPQQLQPEAHFQVQLEQLRSMGFLNREANLQALIATGGDVDAAVEKLRQS 655
            |          |:....:.||..:..|||||:||||.:|..|:.||.||.||::||||:|..|
 Worm   449 P----------SSTAAPVNPEQTYASQLEQLQSMGFSDRARNVAALTATFGDLNAAVERLLNS 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UBQLN3NP_059509.1 Ubl_PLICs 20..92 CDD:340506 29/71 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 102..124 11/22 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 277..330 17/57 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..399 6/34 (18%)
PHA03378 <368..627 CDD:223065 48/264 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 412..447 2/34 (6%)
UBA_PLICs 615..654 CDD:270582 22/38 (58%)
ubql-1NP_740883.1 Ubl_Dsk2p_like 8..80 CDD:340523 29/71 (41%)
rad23 18..>372 CDD:273167 126/489 (26%)
UBA_PLICs 461..500 CDD:270582 22/38 (58%)

Return to query results.
Submit another query.