DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATP5F1B and Jarid2

DIOPT Version :9

Sequence 1:	NP_001677.2	Gene:	ATP5F1B / 506	HGNCID:	830	Length:	529	Species:	Homo sapiens
Sequence 2:	NP_648324.1	Gene:	Jarid2 / 39103	FlyBaseID:	FBgn0036004	Length:	2351	Species:	Drosophila melanogaster

Alignment Length:	444	Identity:	84/444 - (18%)
Similarity:	139/444 - (31%)	Gaps:	84/444 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     9 AAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSP----KAGAATGRIVAVIGA 69
            |.|.||.|..:...:|:.||..:.....|.::.|     :::||:|    |..|..|:..|..|.
  Fly  1357 AKAAASKAATQPRSTAATPPTPISSTPTPASLTP-----SKSSPTPPPAVKQKAEKGKRNATAGG 1416

Human    70 ---------VVDVQFDEGLPPILNALEVQGRETRLVLEVAQH--LGESTVR----TIAMDGTEGL 119
                     ......:....|:.|....:.::.:...:.|.:  .|..|.|    ....|...|.
  Fly  1417 GATALASPPAAPTPANPKRTPVYNQKNAKAQQQQAETKPASNPPSGAGTKRESVYAFGKDDESGS 1481

Human   120 VRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQEILV 184
            ..|.:.....:|:..|.          ::...:.||.|.|.:..|...|.|.: :.:|..:...:
  Fly  1482 KSGNRRRTDPSPVPAPA----------LVPNALSERSPTKKRAAAAAAATAVQ-LTLSPTENCKI 1535

Human   185 TGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHE 249
            .|   ....||..:|.|                 .....|.|.....|.|. |:...||...|..
  Fly  1536 EG---KPSKAPTGRGAK-----------------KQQQQAPAPPAPPVEAS-GDSDAEGATFYIP 1579

Human   250 MIESGVINLKD-ATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQ-------------- 299
            :..:||....| ....||:..|: ..|.|...:|.:....|.:...|...:
  Fly  1580 LQGAGVGGSGDGGIQGVAVKLGR-EGPDGPNQKVVMQATLVTKAQMDTNSKPLPESLNTNELVKT 1643

Human   300 -------DVLLFIDNIFRFTQAGSEVSALLGRIPSA---VGYQPTLATDMGTMQERITTTKKGSI 354
                   |......::....:|.:..:|.....|.|   |......:...|:.:.| |..:..|.
  Fly  1644 LLHAASNDAASTTTSLKSLPKASTSAAAGAAAAPGASSLVRVNSNSSLFSGSAKSR-TAAQTSST 1707

Human   355 TSVQAIYVPADDLTDPAPATTF-AHLDATTVLSRAIAELGIYPAVDPLDSTSRI 407
            .:..|.....|.....|..|.| .|.|.|.::...|.........||::...||
  Fly  1708 AAAVAKKYKDDTPIKMANNTAFPRHDDPTQMVEAPIFRPTEKEFADPIEFIERI 1761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP5F1B	NP_001677.2	PRK09280	58..524	CDD:236447	70/391 (18%)
Jarid2	NP_648324.1	JmjN	1740..1781	CDD:128818	5/22 (23%)
		ARID	1812..1893	CDD:279697
		JmjC	2066..2181	CDD:202224
		zf-C5HC2	2281..2334	CDD:280996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900