DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERPINE1 and Spn42Dd

DIOPT Version :9

Sequence 1:	NP_001373389.1	Gene:	SERPINE1 / 5054	HGNCID:	8583	Length:	492	Species:	Homo sapiens
Sequence 2:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	361	Identity:	109/361 - (30%)
Similarity:	179/361 - (49%)	Gaps:	15/361 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    30 YVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGM 94
            :|..:|......::|.::::..::|:|.||..:.::|:|:.:...|.|.:::|:|:|...:|| .
  Fly     9 WVTSVACQTSKEIYQLLSKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGLPSEDK-E 72

Human    95 APALRH--LYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARF 157
            |.|.|:  |..:|.|......:...:.|:|.....|.|.:.......|:|..:.:..:....|..
  Fly    73 AVAARYGALLNDLQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESISLTNGPVAAE 137

Human   158 IINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSV 222
            .||.||...|.|.|..::..|::....:.:||||:||.|||::.|..:.|....|..:...:|.|
  Fly   138 RINQWVLDQTSGKIKGMIDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRASTFQVTANKSVPV 202

Human   223 PMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKG 287
            .||||...|....|...|.   .::||||....|||.|..|.|.| .||||     .:.|..:..
  Fly   203 QMMAQMGTFRANYFRDLDA---QVIELPYLNSNLSMTIFLPREVE-GLSAL-----EEKIVGFAR 258

Human   288 NMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSL-SDQEPLHVAQALQKVKIEV 351
            .:......|.||||.:|...:|::.||.||:.::|.. ::|.:.| :|:....|:|...|..:||
  Fly   259 PLVAKEVYLKLPKFKIEFRDELKETLEKLGIRELFTD-KSDLSGLFADKSGGKVSQVSHKAFLEV 322

Human   352 NESGTVASSSTAVIVSARMAPEEIIM-DRPFLFVVR 386
            ||.|..|:.:|:|.|:.|......:| |.||.||:|
  Fly   323 NEEGAEAAGATSVAVTNRAGFSTFLMADHPFAFVIR 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPINE1	NP_001373389.1	serpinE1_PAI-1	29..393	CDD:381007	109/361 (30%)
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	107/354 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020