Protein Alignment PAH and pah

DIOPT Version :10

• Sequence 1: NP_000268.1
• Gene: PAH / 5053
• HGNCID: 8582
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001027484.1
• Gene: pah / 613076
• XenbaseID: XB-GENE-991085
• Length: 445
• Species: Xenopus tropicalis
• Alignment Length: 432
• Identity: 336/432 - (77%)
• Similarity: 385/432 - (89%)
• Gaps: 1/432 - (0%)

Human    21 ETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDK 85
            |.:.||:| .::..|||||||||||||||||||:|||.|::|||||||||||.||||:||.:||.
 Frog    15 EVNGIENN-QEDNRISLIFSLKEEVGALAKVLRIFEEKDISLTHIESRPSRLNKDEYQFFINLDD 78

Human    86 RSLPALTNIIKILRHDIGATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFK 150
            :|..||.:||..||:|||||||||||:|:||.|||||||||:||:|||||||||||||||||||.
 Frog    79 KSTHALDDIISCLRNDIGATVHELSRNKRKDAVPWFPRTIQDLDKFANQILSYGAELDADHPGFT 143

Human   151 DPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEK 215
            ||||||.||:||||||||:||||||.|.|.::|||||||||:.||:||.||||||:||:|||||:
 Frog   144 DPVYRALRKEFADIAYNYKHGQPIPHVTYTDQEKKTWGTVFRELKTLYPTHACYEHNHVFPLLEE 208

Human   216 YCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPE 280
            |||::|:|||||||||.|||.|||||||||||||||||||.||||||||.||||||.||||||||
 Frog   209 YCGYNENNIPQLEDVSNFLQKCTGFRLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHWSKPMYTPE 273

Human   281 PDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGA 345
            ||:|||||||.|||:|..|||||||||||||||||||||.|||:||||:|||:|||...:|||||
 Frog   274 PDVCHELLGHAPLFADPGFAQFSQEIGLASLGAPDEYIEMLATVYWFTIEFGICKQDGKLKAYGA 338

Human   346 GLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPF 410
            |||||||||||||::||:..|.|.||||:|.|.:|||||:|::||||.:||||:|.||.||||||
 Frog   339 GLLSSFGELQYCLTDKPEFKPFEPEKTALQKYPITEFQPIYFIAESFEEAKEKIRKFATTIPRPF 403

Human   411 SVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK 452
            ||||:||||.||||||.||||.||:|||||||||||||:|::
 Frog   404 SVRYNPYTQSIEVLDNIQQLKNLAESINSEIGILCSALKKLE 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAH	NP_000268.1	Phe4hydrox_tetr	20..452	CDD:130335	336/430 (78%)
pah	NP_001027484.1	arom_aa_hydroxylase	22..445	CDD:470129	333/423 (79%)