Protein Alignment PAH and Hn

DIOPT Version :10

• Sequence 1: NP_000268.1
• Gene: PAH / 5053
• HGNCID: 8582
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_523963.2
• Gene: Hn / 38871
• FlyBaseID: FBgn0001208
• Length: 452
• Species: Drosophila melanogaster
• Alignment Length: 440
• Identity: 274/440 - (62%)
• Similarity: 340/440 - (77%)
• Gaps: 10/440 - (2%)

Human    20 QETSYIEDNCNQNGA--ISLIFSLKE---EVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEF 79
            ::::||.:..:...|  ..|:||.|:   ..||||.:|.:|:::|:||.||||| |.|:...|||
  Fly    15 EDSAYIVEGVDIKEARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESR-SSLRVPGYEF 78

Human    80 FTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKD--TVPWFPRTIQELDRFANQILSYGAEL 142
            |...|.:| .||...|:.::... :..:.:|||.|.:  .||||||.|::||||||||||||:||
  Fly    79 FVEADGKS-GALGKAIEDVKEQC-SYFNIISRDYKDNATAVPWFPRRIRDLDRFANQILSYGSEL 141

Human   143 DADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYN 207
            |||||||.||.||.|||.||||||||:||:|:|.|:|.:||.:|||.:|:.|..|||||||.|||
  Fly   142 DADHPGFTDPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYN 206

Human   208 HIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHG 272
            |:||||...|||.|||||||||||.||:.||||.||||||||||||||.||||||||.||||||.
  Fly   207 HVFPLLVDNCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHP 271

Human   273 SKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQG 337
            ||||||||||:||||:||||||:|.:|||||||||||||||||:|||||:||:|||||:|:|:|.
  Fly   272 SKPMYTPEPDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQE 336

Human   338 DSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNF 402
            ..:||||||||||:|||:|||::||:|...|.|.|.:..|.:|:||||||||:||..||||...|
  Fly   337 GELKAYGAGLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKF 401

Human   403 AATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK 452
            |.:|||||.|||:.|||.:||||:..|:..|.|:||||..||.:|:.|::
  Fly   402 ANSIPRPFGVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKLR 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAH	NP_000268.1	Phe4hydrox_tetr	20..452	CDD:130335	274/438 (63%)
Hn	NP_523963.2	Phe4hydrox_tetr	15..451	CDD:130335	274/438 (63%)