Protein Alignment PAH and ple

DIOPT Version :9

• Sequence 1: NP_000268.1
• Gene: PAH / 5053
• HGNCID: 8582
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001286955.1
• Gene: ple / 38746
• FlyBaseID: FBgn0005626
• Length: 579
• Species: Drosophila melanogaster
• Alignment Length: 418
• Identity: 205/418 - (49%)
• Similarity: 283/418 - (67%)
• Gaps: 2/418 - (0%)

Human    36 SLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRH 100
            :|:..|||.:.:|.::|:..|.....:.|:|||.||::..:::....|| .:...|..:|:.||.
  Fly   160 ALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLD-MTRGNLLQLIRSLRQ 223

Human   101 DIGATVHELSRDKKKDT-VPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADI 164
            ....:...|..|...:. .||||:...|||...:.:..|..:||.:||||.|.|||.|||:.|:|
  Fly   224 SGSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGFADKVYRQRRKEIAEI 288

Human   165 AYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLED 229
            |:.|::|.|||.::|.:.|.|||.:||||::.|...|||.||...|..|:....|.|..:|||::
  Fly   289 AFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDEQIFVETRLPQLQE 353

Human   230 VSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLF 294
            :|.||:..|||.|||.||||::||||..||||:|..|||:||.:.|.:|||||..||||||:||.
  Fly   354 MSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTPEPDSIHELLGHMPLL 418

Human   295 SDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLS 359
            :|.||||||||||||||||.||.||||:|:|||||||||||:...|||||||||||:|||.:.:|
  Fly   419 ADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGAGLLSSYGELLHAIS 483

Human   360 EKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVL 424
            :|.:....|...||:|.|...|:||:|||||||.|||:|.|.:.:|:.|||.||::|:|:|:|||
  Fly   484 DKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVL 548

Human   425 DNTQQLKILADSINSEIGILCSALQKIK 452
            |:..:|:.|...:|:||..|.:|:.|::
  Fly   549 DSVDKLETLVHQMNTEILHLTNAISKLR 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAH	NP_000268.1	Phe4hydrox_tetr	20..452	CDD:130335	205/416 (49%)
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	205/416 (49%)
		ACT	130..234	CDD:298841	20/74 (27%)
		Biopterin_H	243..573	CDD:278766	183/329 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820