Protein Alignment PAH and pah

DIOPT Version :10

• Sequence 1: NP_000268.1
• Gene: PAH / 5053
• HGNCID: 8582
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_956845.1
• Gene: pah / 378962
• ZFINID: ZDB-GENE-031006-2
• Length: 449
• Species: Danio rerio
• Alignment Length: 444
• Identity: 334/444 - (75%)
• Similarity: 376/444 - (84%)
• Gaps: 3/444 - (0%)

Human     8 NPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRL 72
            |.||.||.|   ..:||:|:..|::|.:|.|||||||||||.:.|:||||..:|||||||||||.
Zfish     9 NGGLERKGS---LTSSYLEEPLNKSGVVSCIFSLKEEVGALVEALKLFEEKGINLTHIESRPSRK 70

Human    73 KKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPWFPRTIQELDRFANQILS 137
            ..:|||||..:|:.|...|..|:..||..|...||||||:|:||||||||..||:||||||||||
Zfish    71 NNEEYEFFISVDQASSKVLDEIVDGLRTQIRGQVHELSRNKQKDTVPWFPNDIQDLDRFANQILS 135

Human   138 YGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHA 202
            ||:|||||||||.|.|||||||:|||||||||||||||||||..|||.||||||:.||:||.|||
Zfish   136 YGSELDADHPGFTDTVYRARRKEFADIAYNYRHGQPIPRVEYTAEEKATWGTVFRELKTLYPTHA 200

Human   203 CYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQ 267
            |.|:|.:|||||||||:.|||||||||:|.:||:|||||||||||||||||||.||||||||.||
Zfish   201 CREHNRVFPLLEKYCGYREDNIPQLEDISHYLQSCTGFRLRPVAGLLSSRDFLAGLAFRVFHSTQ 265

Human   268 YIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFG 332
            ||||.||||||||||||||||||||||:|.:||||||||||||||||||:||||||:||||||||
Zfish   266 YIRHSSKPMYTPEPDICHELLGHVPLFADPNFAQFSQEIGLASLGAPDEFIEKLATVYWFTVEFG 330

Human   333 LCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKE 397
            |||||:.:||||||||||||||||||:.:|||.|.|.|||..|.|.:|||||:|:|||||.||||
Zfish   331 LCKQGNEVKAYGAGLLSSFGELQYCLTNEPKLQPFEPEKTCQQKYPITEFQPVYFVAESFEDAKE 395

Human   398 KVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKI 451
            |||.||.||||||||||:.||||||:|||.||||.||||||.||.|||:||:|:
Zfish   396 KVRRFATTIPRPFSVRYNAYTQRIEMLDNAQQLKNLADSINGEISILCNALRKM 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAH	NP_000268.1	Phe4hydrox_tetr	20..452	CDD:130335	328/432 (76%)
pah	NP_956845.1	arom_aa_hydroxylase	20..449	CDD:470129	327/428 (76%)