Protein Alignment PAH and pah-1

DIOPT Version :10

• Sequence 1: NP_000268.1
• Gene: PAH / 5053
• HGNCID: 8582
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001254185.1
• Gene: pah-1 / 174401
• WormBaseID: WBGene00000240
• Length: 457
• Species: Caenorhabditis elegans
• Alignment Length: 455
• Identity: 253/455 - (55%)
• Similarity: 322/455 - (70%)
• Gaps: 17/455 - (3%)

Human     9 PGLGRKLSDFGQET--SYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSR 71
            |..|:...||.:..  ||:.|.....|..:::|:|:|:.||||:.|:||:.:||||:|||||||:
 Worm     2 PPAGQDDLDFLKYAMESYVADVNADIGKTTIVFTLREKAGALAETLKLFQAHDVNLSHIESRPSK 66

Human    72 LKKDEYEFFTHL----DKRSLPALTNII------KILRHDIGATVHELSRDKKKDTVPWFPRTIQ 126
            ..:..||.....    |.|.:..:....      |:|..|     ......:.||:|||||:.|.
 Worm    67 THEGCYEVLVEFAEAEDHRKIEGVIEHFQQKAEKKVLVQD-----WNTKNKQNKDSVPWFPQKIN 126

Human   127 ELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVF 191
            ::|:|||:|||||||||||||||||..||.|||.|||||:|::||..||.:.|.:||..||.||:
 Worm   127 DIDQFANRILSYGAELDADHPGFKDMTYRERRKFFADIAFNFKHGDKIPTITYTDEEIATWRTVY 191

Human   192 KTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLG 256
            ..|..:|..:||.|:|:|||||::.|||..|.||||:|||.||:.|||:.:|||||||||||||.
 Worm   192 NELTVMYPKNACQEFNYIFPLLQQNCGFGPDRIPQLQDVSDFLKDCTGYTIRPVAGLLSSRDFLA 256

Human   257 GLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKL 321
            ||||||||.||||||.|.|.||||||||||||||||||:|..|||||||||||||||||:.||||
 Worm   257 GLAFRVFHSTQYIRHHSAPKYTPEPDICHELLGHVPLFADVEFAQFSQEIGLASLGAPDDVIEKL 321

Human   322 ATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLY 386
            ||:||||:|||:|:|....||||||||||||||||.||:||:::..:.....:..|.:||:||.|
 Worm   322 ATLYWFTIEFGICQQDGEKKAYGAGLLSSFGELQYALSDKPEVVDFDPAVCCVTKYPITEYQPKY 386

Human   387 YVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKI 451
            ::||||..||.|::::||||.|||.:||:.||||:|:||....|:.||..|.|:|..|..||.|:
 Worm   387 FLAESFASAKNKLKSWAATINRPFQIRYNAYTQRVEILDKVAALQRLARDIRSDISTLEEALGKV 451

Human   452  451
             Worm   452  451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAH	NP_000268.1	Phe4hydrox_tetr	20..452	CDD:130335	249/444 (56%)
pah-1	NP_001254185.1	Phe4hydrox_tetr	15..452	CDD:130335	249/442 (56%)