DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DUOX2 and Nox

DIOPT Version :9

Sequence 1:NP_001350640.1 Gene:DUOX2 / 50506 HGNCID:13273 Length:1548 Species:Homo sapiens
Sequence 2:NP_001097336.1 Gene:Nox / 5740310 FlyBaseID:FBgn0085428 Length:1340 Species:Drosophila melanogaster


Alignment Length:1475 Identity:283/1475 - (19%)
Similarity:469/1475 - (31%) Gaps:633/1475 - (42%)


- Green bases have known domain annotations that are detailed below.


Human   563 HKGA------------PCPQPKQLT-TDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLL 614
            |:|:            |...||::: :|.|||..........:.|:|            .:||.:
  Fly    10 HRGSVSSSRSLEIPATPSRSPKKVSFSDELPQSQTPAQQPINQQSAP------------TVVSHV 62

Human   615 LSGVVAYFRGREH---KKLQKKLKE-----------SVKKEAAKDGVPAMEW--------PGPKE 657
            |.....|.. |.|   ...::|.:|           |...|||...:.|::.        .||..
  Fly    63 LQQAAQYLE-RLHGARDSAEEKTEEVQPERADIRDSSDTSEAAVLDLDALDASADEPAANAGPIV 126

Human   658 RSSPIIIQLLSDRCLQVLNRHLTV------------LRVVQLQPLQQVNLILSNNRGCRTLLLKI 710
            .|||.|:       :..:||...:            .|...|. :::.||.|..|  |.::.|:.
  Fly   127 ASSPSIL-------IGSVNRQEAIGSANGNGNANPNQRQSNLY-MERYNLNLDKN--CSSMELEA 181

Human   711 PKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQ-RERILEIF--- 771
            .:|....||.|   |..|...:        ..|.|.     :|.|||....:: ::::.::|   
  Fly   182 RREKQRWLLIS---ECSALFDE--------GEGKHT-----REAFRKLFLDEEFQQKLFQLFDLE 230

Human   772 ----------FRHLFAQVLDINQAD------------------------------AGTLP----- 791
                      ..||..::.|..|.|                              .|.|.     
  Fly   231 RNGYLLQDRWIEHLKGRLTDDRQMDFAEQIESVAYVICGENKRVSFKNFRDIWHTRGILDKLYRL 295

Human   792 -------LDSSQKVREALT------------------------------CELSRAEFAESLGLKP 819
                   |.|:.:|.|.::                              .|:.|.||.:.:..| 
  Fly   296 IELDGSNLVSTNQVMEFISHLTNSRPRTGFDKSSLARLEQLFRTTVGNEQEIRREEFQKIVTSK- 359

Human   820 QDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMM 884
            ...|.|.:|.:.|||.:|.:|.:||:|.:..|...|.:||.|.:|.:||:|.:|.:...|...::
  Fly   360 NPFFTERVFQIFDKDNSGSISLQEFIDAIHQFSGQSADDKIRFLFKVYDIDGDGLIQHKELHDVI 424

Human   885 RSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGG 949
            |..|:.:....|:.|:.::..:||.::...:..|:|:|.....|..|                ||
  Fly   425 RHCIKENGMEFSEDQIEDLTSAMFEDADPHNSGEITYEALKNQLHKH----------------GG 473

Human   950 NGIRDIFKQNISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEA 1014
                  ..:|:|..:.            :.|.|.| |..:.||..                    
  Fly   474 ------LLENLSITID------------RWLVPIA-EDRQAGGAA-------------------- 499

Human  1015 LQEKMQRGFLAQKLQQYK-RFVENYRRHIVCVAIFSAICVGVFADRAYYY----GFASPPSDIAQ 1074
                 :.||......|:. .:::|.:..:..:..:..:.:.:|..||..|    ||         
  Fly   500 -----KSGFWNSLPHQFSLAYMKNNQVFVTYLFFYITVNLCLFISRAIQYRASNGF--------- 550

Human  1075 TTLVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAI 1139
                 :|::|.....::|..:::|:.|.|:.:|:||...|:.|:|.|..|..|:...:...||::
  Fly   551 -----VIIARACGQCLNFNCAWVLVLMLRHSLTYLRGRGLSSYLPLDHHVYLHKLTGITISVLSL 610

Human  1140 LHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGM----------TGVL 1194
            :|:..|..|..|..::.        ||  :|.|.....:   |.....||:          |||.
  Fly   611 IHTIMHLFNFSIIVIND--------PN--INAGHYTIGE---WLLTDRPGLFGLIPGCANPTGVA 662

Human  1195 LLLVLAIMYVFASHHFRRR-SFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYG 1258
            ||.:|.:|:|.:....||: ||..|:.||.||:..:.|.:.||       |.|..:||:|.::|.
  Fly   663 LLAILVVMFVCSQPFVRRKGSFEVFYWTHLLYVPFWILCLFHG-------PNFWKWFLLPGLVYI 720

Human  1259 GDKLVSL-----SRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPF 1318
            .::.:..     ...|..||  ...||||.|.:|..:||..|.::.|.:|.:...|:...|:|||
  Fly   721 VERALRFIWMRGEHGKTYIS--SGLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIANYEWHPF 783

Human  1319 TLTSAP-HEDTLSLHIRAVGPWTTRL-----------------REI------------------- 1346
            |::||| .||.:.||||.||.||.||                 :||                   
  Fly   784 TISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEAR 848

Human  1347 ----------------------------------------------------------------- 1346
                                                                             
  Fly   849 NPAIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTF 913

Human  1347 ----------------------------------------------------------------- 1346
                                                                             
  Fly   914 SRKEAVDPKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSESES 978

Human  1347 ------------------YSSP------------------------------------KGNGC-- 1355
                              |.||                                    :.||.  
  Fly   979 AFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGASP 1043

Human  1356 ----------------------------------------------------------------- 1355
                                                                             
  Fly  1044 ASRAEQGQLSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSASINN 1108

Human  1356 ------------------------AGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASIL 1396
                                    ||..::::|||:|.........:.:||:|.|||||||||||
  Fly  1109 RTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFASIL 1173

Human  1397 KDLVFK----------------SSL-GSQMLCKKIYFIWVTRTQRQFEWLADIIQ--EVEEND-- 1440
            :.::.:                |.: .|.|..:|:.|.|:.|.||.|||..:::.  |:|:.:  
  Fly  1174 QSIMHRYWKARHSCPRCQFEWASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQLEIEQAELG 1238

Human  1441 --HQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQ 1503
              .:..:.:|:|:|...::.|::...|.:......:...|.|.|||::.|:.|||.::..|..||
  Fly  1239 GAMERFLDMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLITGLKTRTNAGRPNWDKVFKQLQ 1303

Human  1504 EVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF 1548
            .  .|..|:.||.||||.:.|.:...|      |:..|....|.|
  Fly  1304 A--QQKGKVTVFYCGPPQLAKTLRYKC------DQYGFAFRKECF 1340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DUOX2NP_001350640.1 Peroxidase-like, mediates peroxidase activity. /evidence=ECO:0000250 30..596 10/45 (22%)
dual_peroxidase_like 38..594 CDD:188652 9/43 (21%)
EFh_PEF <764..858 CDD:330173 30/178 (17%)
EFh 824..885 CDD:238008 21/60 (35%)
EF-hand_7 857..929 CDD:316058 18/71 (25%)
Interaction with TXNDC11. /evidence=ECO:0000250 960..1245 65/300 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..991 4/19 (21%)
Ferric_reduct 1088..1223 CDD:307763 40/145 (28%)
NOX_Duox_like_FAD_NADP 1274..1548 CDD:99783 103/608 (17%)
NoxNP_001097336.1 FRQ1 314..466 CDD:227455 36/152 (24%)
EFh 365..425 CDD:238008 21/59 (36%)
EFh 399..462 CDD:238008 16/62 (26%)
Ferric_reduct 560..700 CDD:280043 43/152 (28%)
NOX_Duox_like_FAD_NADP 744..>819 CDD:99783 32/74 (43%)
FNR_like <1136..>1178 CDD:297884 18/41 (44%)
NAD_binding_6 1158..1325 CDD:285298 54/168 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0039
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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