Protein Alignment DUOX2 and CG42331

DIOPT Version :10

• Sequence 1: NP_054799.4
• Gene: DUOX2 / 50506
• HGNCID: 13273
• Length: 1548
• Species: Homo sapiens
• Sequence 2: NP_651282.2
• Gene: CG42331 / 42948
• FlyBaseID: FBgn0259233
• Length: 1615
• Species: Drosophila melanogaster
• Alignment Length: 731
• Identity: 181/731 - (24%)
• Similarity: 284/731 - (38%)
• Gaps: 159/731 - (21%)

Human     3 RARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYAD 67
            ::..:.:.|....|.|...|......:......:.:||..||.|....||......|.:|..|.|
  Fly   151 QSHTQRISLRRTALEGLCPPRDPPPCMPASERYRTHDGTCNNKRRPRWGAAQMPFNRFLPPEYGD 215

Human    68 G---VYQALEEPQLPNPRRLS---NAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSV------- 119
            |   |..:.:...|.:.|.:|   :.|..|.|.|      |::...:|..:..|:.|.
  Fly   216 GVDTVRSSADGSTLSSSRFVSLLVHGAREGEAPL------TLMIAQWGQMLDHDMTSTAQPRSIN 274

Human   120 -ETPGC-------PAEFLNIRIPPGDPVF-------------DPDQRGDVVLPFQRSRWDPETGR 163
             ..|.|       ||.| .|::|..||..             .|.||.|.||     .|
  Fly   275 GSIPSCCGGKDFHPACF-PIKVPLDDPWLAPLKVRCLEFLRSAPAQRRDCVL-----SW------ 327

Human   164 SPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPA 228
                 |:..||||.::|.|.||.:|...||..|.|..|                 ||::...|||
  Fly   328 -----REQTNQVTSYIDASPIYSNSAKSSDNARVFRHG-----------------LLVYGRGDPA 370

Human   229 TGQNGPRGLYA-----FGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKR 288
            . ....||..|     .|..|...:|.|.|:..:|...||..|..|:..:|.|.||:::|..|:.
  Fly   371 E-DVCQRGAIATKCIRSGDGRSGEQPGLLAMHHVWVGEHNRIAMELSELNPHWSDEKVYQETRRI 434

Human   289 VIATYQNIAVYEWLPSFLQKTLPE-----------YTGYRPFLDPSISPEFVVASEQFFSTMVPP 342
            |.|.:|:|...|:||..|.:.:.:           |..|...::|:::..|..|:.:|..::| .
  Fly   435 VGAMFQHITFREFLPVILGREVVKLFDLELMPSGYYERYSSKVNPTVANAFAAAAFRFGHSLV-Q 498

Human   343 GVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRE---NPNLNSTQEVNELLLGMASQISELEDN 404
            ..|.|....|  .|:|            ||..:.|   ..::.|...::.||.|:|||.:...|.
  Fly   499 NSYTRCDRHH--NVIN------------NNVSLHEEFQRGDIGSAGSLHRLLRGLASQRALKRDE 549

Human   405 IVVEDLRDY-WPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVL 468
            .:..:|.:: :..||.....|..|.:||||||.|:..||...:..||....:|.|....|.|:..
  Fly   550 FITPELTNHLFQTPGFPFGLDLAAINIQRGRDHGIAPYSAWRVPCGLSPILSWDDFANVVGPESA 614

Human   469 EATAALYNQDLSQLELLLGGLLES---HGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGL---F 527
            :.....| :.:..::|.:||:.|.   .|..||.|:.|:..||...|.|||:|:||  .|.   |
  Fly   615 KRIGHAY-RSVHDIDLFVGGIAERPVVGGLVGPTFACIIAQQFSNSRRGDRFWYEN--GGFESSF 676

Human   528 SKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFV------------------------WHKGAPC 568
            :..::..:|..:|..||...:.  ...|||::|:                        |.:..|.
  Fly   677 TPAQLHSLRRVSLAQVLCRTVG--GGTLQPHIFIPAEFEDNERQTCGVGSLSPIDLSPWLEQDPF 739

Human   569 PQ---PKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFRGREHK-- 628
            ..   |:|:.|.|.|:...:.::   :....||:..:..:  .|.|.:..|.:..:.|.....
  Fly   740 HNQQVPEQVFTIGQPELGSVQII---KEDKAGFSNRVKPI--KPQVEVSPSSLSGFHRPTNENLT 799

Human   629 ----KLQKKLKESVKK 640
                ||..:.|...||
  Fly   800 KVSDKLDLRRKTVTKK 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DUOX2	NP_054799.4	dual_peroxidase_like	38..594	CDD:188652	166/642 (26%)
		EFh	824..885	CDD:238008
		EFh	861..919	CDD:238008
		COG4097	1037..1548	CDD:443273
		NOX_Duox_like_FAD_NADP	1274..1548	CDD:99783
CG42331	NP_651282.2	An_peroxidase	183..707	CDD:460804	158/584 (27%)
		LHP1	731..>871	CDD:227520	18/90 (20%)