DRSC/TRiP Functional Genomics Resources

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Protein Alignment DUOX2 and cysu

DIOPT Version :9

Sequence 1:NP_001350640.1 Gene:DUOX2 / 50506 HGNCID:13273 Length:1548 Species:Homo sapiens
Sequence 2:NP_650627.1 Gene:cysu / 42100 FlyBaseID:FBgn0038511 Length:753 Species:Drosophila melanogaster


Alignment Length:593 Identity:150/593 - (25%)
Similarity:250/593 - (42%) Gaps:88/593 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    32 PWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRR---LSNAATRGIA 93
            |.:.:|:||..||:.|...||.....||.:...|:||:    ..|::....|   .|...:|.:.
  Fly   152 PGKYRRFDGLCNNIEHPTWGAANAPFQRLIGPLYSDGI----NAPRISVTGRDLPFSRVVSRTMH 212

Human    94 GLPSLHNR--TVLGVFFGYHVLSDVVSVETPGCPAE-----------------FLN-IRIPPGD- 137
            .....|:.  ||:.:.:|..:..|.....||..|..                 :.| ||||..| 
  Fly   213 PDDGFHDHAGTVMVIAWGQFMDHDFTLTGTPLDPINRNDPEECCKRPLHLKHPYCNEIRIPDDDY 277

Human   138 --PVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSG 200
              .:|:..     .:.|.|....|..| .....|...|.:||.:|.:.:||...|::..||:..|
  Fly   278 FYRLFNVK-----CIDFVRGFPSPRPG-CKLGSRQQFNTLTGVIDANTVYGVKESFARKLRTGYG 336

Human   201 GQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGP-RGLYAF--GAERGNREPFLQALGLLWFRYH 262
            |.:..  :|.|.......||......|..|...| :.:|.|  |..|.|.:..|..:..|..|.|
  Fly   337 GLMRM--NPVFQEYGLKDLLPLKLDIPDEGCTRPNKSMYCFEGGEIRVNEQLVLTCMHTLMAREH 399

Human   263 NLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPE-----------YTGY 316
            |..|..||:.:..|:||.|||.||:..||..|::...|:||..|.|.:.|           :.||
  Fly   400 NRLATALAQINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGY 464

Human   317 RPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNL 381
            ...::|.|...|..|:.:|..:::|..| .|.:..|       .|.:|:.|    :..||...:|
  Fly   465 DSTVNPGIIDSFAGAAFRFGHSLLPTAV-ERWSKAH-------KFIASKRL----SDLIRRPYDL 517

Human   382 NSTQEVNELLLGMASQISE-LEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQAL 445
            .....::|..:|:.:|::: ::|:|..|.....:...|.....|.|:.::||||:.|:|.|.:..
  Fly   518 YRAGVLDEYFMGLMNQVAQAMDDSITQEVTNHLFKKEGARFGMDLVSFNMQRGREFGIPGYMEFR 582

Human   446 LAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESH--GDP-GPLFSAIVLDQ 507
            ...||.....|.::..::..:.:....:::... :.::|..||:.|..  |.. ||.|:.::..|
  Fly   583 KFCGLPTSNTWDEMYGSMPNETVLRYGSIFEHP-ADIDLWSGGVSEKSLPGSMLGPTFACVIATQ 646

Human   508 FVRLRDGDRYWFE-NTRNGLFSKKEIEDIRNTTLRDV------LVAVINIDPSAL-----QPNVF 560
            ...||.|||:|:| ..:...|:.:::::||...|..:      |:..:.|.|..|     .|.| 
  Fly   647 MSYLRRGDRFWYELPNQPSSFTPEQLQEIRKAKLSRLICDNTDLIDTVQIYPMVLPDHEINPRV- 710

Human   561 VWHKGAPC 568
                  ||
  Fly   711 ------PC 712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DUOX2NP_001350640.1 Peroxidase-like, mediates peroxidase activity. /evidence=ECO:0000250 30..596 150/593 (25%)
dual_peroxidase_like 38..594 CDD:188652 148/587 (25%)
EFh_PEF <764..858 CDD:330173
EFh 824..885 CDD:238008
EF-hand_7 857..929 CDD:316058
Interaction with TXNDC11. /evidence=ECO:0000250 960..1245
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..991
Ferric_reduct 1088..1223 CDD:307763
NOX_Duox_like_FAD_NADP 1274..1548 CDD:99783
cysuNP_650627.1 An_peroxidase 155..692 CDD:281139 142/561 (25%)
peroxinectin_like 305..687 CDD:188655 105/396 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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