Protein Alignment DUOX2 and cysu

DIOPT Version :10

• Sequence 1: NP_054799.4
• Gene: DUOX2 / 50506
• HGNCID: 13273
• Length: 1548
• Species: Homo sapiens
• Sequence 2: NP_650627.1
• Gene: cysu / 42100
• FlyBaseID: FBgn0038511
• Length: 753
• Species: Drosophila melanogaster
• Alignment Length: 593
• Identity: 150/593 - (25%)
• Similarity: 250/593 - (42%)
• Gaps: 88/593 - (14%)

Human    32 PWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRR---LSNAATRGIA 93
            |.:.:|:||..||:.|...||.....||.:...|:||:    ..|::....|   .|...:|.:.
  Fly   152 PGKYRRFDGLCNNIEHPTWGAANAPFQRLIGPLYSDGI----NAPRISVTGRDLPFSRVVSRTMH 212

Human    94 GLPSLHNR--TVLGVFFGYHVLSDVVSVETPGCPAE-----------------FLN-IRIPPGD- 137
            .....|:.  ||:.:.:|..:..|.....||..|..                 :.| ||||..|
  Fly   213 PDDGFHDHAGTVMVIAWGQFMDHDFTLTGTPLDPINRNDPEECCKRPLHLKHPYCNEIRIPDDDY 277

Human   138 --PVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSG 200
              .:|:..     .:.|.|....|..| .....|...|.:||.:|.:.:||...|::..||:..|
  Fly   278 FYRLFNVK-----CIDFVRGFPSPRPG-CKLGSRQQFNTLTGVIDANTVYGVKESFARKLRTGYG 336

Human   201 GQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGP-RGLYAF--GAERGNREPFLQALGLLWFRYH 262
            |.:..  :|.|.......||......|..|...| :.:|.|  |..|.|.:..|..:..|..|.|
  Fly   337 GLMRM--NPVFQEYGLKDLLPLKLDIPDEGCTRPNKSMYCFEGGEIRVNEQLVLTCMHTLMAREH 399

Human   263 NLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPE-----------YTGY 316
            |..|..||:.:..|:||.|||.||:..||..|::...|:||..|.|.:.|           :.||
  Fly   400 NRLATALAQINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGY 464

Human   317 RPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNL 381
            ...::|.|...|..|:.:|..:::|..| .|.:..|       .|.:|:.|    :..||...:|
  Fly   465 DSTVNPGIIDSFAGAAFRFGHSLLPTAV-ERWSKAH-------KFIASKRL----SDLIRRPYDL 517

Human   382 NSTQEVNELLLGMASQISE-LEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQAL 445
            .....::|..:|:.:|::: ::|:|..|.....:...|.....|.|:.::||||:.|:|.|.:..
  Fly   518 YRAGVLDEYFMGLMNQVAQAMDDSITQEVTNHLFKKEGARFGMDLVSFNMQRGREFGIPGYMEFR 582

Human   446 LAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESH--GDP-GPLFSAIVLDQ 507
            ...||.....|.::..::..:.:....:::... :.::|..||:.|..  |.. ||.|:.::..|
  Fly   583 KFCGLPTSNTWDEMYGSMPNETVLRYGSIFEHP-ADIDLWSGGVSEKSLPGSMLGPTFACVIATQ 646

Human   508 FVRLRDGDRYWFE-NTRNGLFSKKEIEDIRNTTLRDV------LVAVINIDPSAL-----QPNVF 560
            ...||.|||:|:| ..:...|:.:::::||...|..:      |:..:.|.|..|     .|.|
  Fly   647 MSYLRRGDRFWYELPNQPSSFTPEQLQEIRKAKLSRLICDNTDLIDTVQIYPMVLPDHEINPRV- 710

Human   561 VWHKGAPC 568
                  ||
  Fly   711 ------PC 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DUOX2	NP_054799.4	dual_peroxidase_like	38..594	CDD:188652	148/587 (25%)
		EFh	824..885	CDD:238008
		EFh	861..919	CDD:238008
		COG4097	1037..1548	CDD:443273
		NOX_Duox_like_FAD_NADP	1274..1548	CDD:99783
cysu	NP_650627.1	An_peroxidase	155..699	CDD:460804	143/568 (25%)