Protein Alignment DUOX2 and Irc

DIOPT Version :10

• Sequence 1: NP_054799.4
• Gene: DUOX2 / 50506
• HGNCID: 13273
• Length: 1548
• Species: Homo sapiens
• Sequence 2: NP_650584.1
• Gene: Irc / 42049
• FlyBaseID: FBgn0038465
• Length: 697
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 160/599 - (26%)
• Similarity: 242/599 - (40%)
• Gaps: 139/599 - (23%)

Human    43 NNLRHHERGAVGCRLQRRV--PANYADGVYQALEEPQLPNP-RRLSNAATRGIA----------- 93
            |:|:.:..|....   ||:  .::|.:|.||     ..||. ||.:..|...|:
  Fly   142 NSLKGNREGHYAF---RRLLGSSHYRNGFYQ-----MFPNSGRRETVPAAWSISKELYEPDHIQI 198

Human    94 ------------GLPSLHNRTVLGVFFGYHVLSDVVSVE-TPGCPAEF-----LNIR----IPPG 136
                        .||....       |..|.||..||.. :.|.|.|.     :|::    .|..
  Fly   199 SKQQTFESNSNLALPQWAQ-------FVEHDLSKPVSQSMSNGAPIECCSRDQINLQPRHHHPAC 256

Human   137 DPV-FDPDQRGDV--VLPFQRSRW---DPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDAL 195
            .|: :.|..:.||  .|.:.||..   |...|.:     :..||.||.||.|.:||.:.:....|
  Fly   257 APILYQPGGKYDVPSCLNYVRSALAVADCNFGGA-----EQLNQATGSLDLSQLYGFTAAAERKL 316

Human   196 RSFSGGQLASGPDPAFPRDSQNPLLMWAAPDP-ATGQNGPR----------GLYAFGAERGNREP 249
            |...||.|.|.|...|    .|.||      | ||...||.          ..:|.|..|.|..|
  Fly   317 RVLEGGLLRSTPRGEF----DNALL------PIATDTEGPSFCARATIGDGTCFAAGDSRVNSSP 371

Human   250 FLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL-QKTLPEY 313
            |...:..::.|.||..|..|.:::|.|.||:|||.|:...:..|:.:.:.||||..| ||...|.
  Fly   372 FSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEI 436

Human   314 TGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLN-----------KGFQ---SS 364
            ...:|.....:|.||.||:.:|:.:|:|            .::||           |..|   .|
  Fly   437 RRKQPNRALEVSNEFAVAAIRFYFSMLP------------NELLNLTKDNVVYGTEKNNQYVFIS 489

Human   365 QALRVCNNYWIRE---NPNLNST-QEVNELLLGMASQISELED-----NIVVEDLRDYWPGPGKF 420
            :.|...|.:.::|   .|.|..| |::|.:|..:.:|.:...|     .:|       |....|.
  Fly   490 KELPTKNLFELKEEIYKPKLQYTSQKLNNILESLLNQETMKMDAAYSGGVV-------WHKDTKP 547

Human   421 SRTDYVASSIQRGRDMGLPSYSQALLAFGLDIP-RNWSDLNPNVDPQVLEATAALYNQDLSQLEL 484
            :..|.:|..||||||.||..|.:.|.:..|..| .:|.|....:...||:....:| ...:.::|
  Fly   548 THADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVLDKLKTIY-ASWADVDL 611

Human   485 LLGGLLES--HGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKE-IEDIRNTTLRDVLVA 546
            ::||:.|:  ||..||.||.|:.:|||.:..      :|.:..:....| :|..|:  .....:.
  Fly   612 IVGGISENPVHGSIGPTFSCIISEQFVHVLK------QNQQKAVQKHTELVEQYRH--FNGTKLL 668

Human   547 VINIDPSALQPNVF 560
            .:|...||:..|:|
  Fly   669 CLNSGLSAVPQNIF 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DUOX2	NP_054799.4	dual_peroxidase_like	38..594	CDD:188652	160/599 (27%)
		EFh	824..885	CDD:238008
		EFh	861..919	CDD:238008
		COG4097	1037..1548	CDD:443273
		NOX_Duox_like_FAD_NADP	1274..1548	CDD:99783
Irc	NP_650584.1	An_peroxidase	151..682	CDD:460804	156/588 (27%)