DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DUOX2 and Duox

DIOPT Version :9

Sequence 1:	NP_001350640.1	Gene:	DUOX2 / 50506	HGNCID:	13273	Length:	1548	Species:	Homo sapiens
Sequence 2:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster

Alignment Length:	1578	Identity:	608/1578 - (38%)
Similarity:	906/1578 - (57%)	Gaps:	120/1578 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     8 ALMLLGALLTGSLGPSGSQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQA 72
            ||:||.......||.....:.:....|.||||||:|||.|.:.|:|...|.|:.|.:|:|||| |
  Fly    42 ALLLLLISYGLELGSVHCYEKMYSQTEKQRYDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVY-A 105

Human    73 LEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEFLNIRIPPGD 137
            :.....|:.||||....||..||.|..|||.|..|||..|.:::|.....|||.|...|.|...|
  Fly   106 MAGANRPSTRRLSRLFMRGKDGLGSKFNRTALLAFFGQLVANEIVMASESGCPIEMHRIEIEKCD 170

Human   138 PVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQ 202
            .::|.:.|||..:||.|:.:|.:||:||:.||:..||:|.|:|||.||.:|.:|.:|:|||..|.
  Fly   171 EMYDRECRGDKYIPFHRAAYDRDTGQSPNAPREQINQMTAWIDGSFIYSTSEAWLNAMRSFHNGT 235

Human   203 LASGPDPAFPRDSQNPLLMWAAPDPATGQN-GPRGLYAFGAERGNREPFLQALGLLWFRYHNLWA 266
            |.:..|...|..:...:.::..|.|:..:. .|..|:..|..|.|:.|.:.:..:|:.|:||..|
  Fly   236 LLTEKDGKLPVRNTMRVPLFNNPVPSVMKMLSPERLFLLGDPRTNQNPAILSFAILFLRWHNTLA 300

Human   267 QRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISPEFVVA 331
            ||:.|.||||.||:::|.||..|||:.||:.|||:||:||..:||.|.||:..:.|.|...|..|
  Fly   301 QRIKRVHPDWSDEDIYQRARHTVIASLQNVIVYEYLPAFLGTSLPPYEGYKQDIHPGIGHIFQAA 365

Human   332 SEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMAS 396
            :.:|..||:|||:|.|:..|:|::. ..|:   .|:|:|:.:|  ::....:...|.|:|:|:||
  Fly   366 AFRFGHTMIPPGIYRRDGQCNFKET-PMGY---PAVRLCSTWW--DSSGFFADTSVEEVLMGLAS 424

Human   397 QISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNP 461
            ||||.||.::..|:||...||.:|:|.|..|.:|.||||.|||.|:.|..::||...:.|:|:||
  Fly   425 QISEREDPVLCSDVRDKLFGPMEFTRRDLGALNIMRGRDNGLPDYNTARESYGLKRHKTWTDINP 489

Human   462 ---NVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTR 523
               ...|::|:.....|:..|..:::.:||:|||:|.||..|:|::.:||.||||.||:||||.|
  Fly   490 PLFETQPELLDMLKEAYDNKLDDVDVYVGGMLESYGQPGEFFTAVIKEQFQRLRDADRFWFENER 554

Human   524 NGLFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVL 588
            ||:|:.:||.::|..||.|::|...::....:|.:||:|..|.|||||.||....|..|..|...
  Fly   555 NGIFTPEEIAELRKITLWDIIVNSTDVKEEEIQKDVFMWRTGDPCPQPMQLNATELEPCTYLEGY 619

Human   589 DFFEGSSPGFAITIIALCC-LPLVSLLLSGVVAYFRGREHKKLQ--KKLKESVKKEAAK------ 644
            |:|.||.    :..|.:|. |..|.:|.:|.     |....|||  |:.:..:::||.:
  Fly   620 DYFSGSE----LMFIYVCVFLGFVPILCAGA-----GYCVVKLQNSKRRRLKIRQEALRAPQHKG 675

Human   645 --DGVPAMEWPGPKERSSPIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRT-- 705
              |.:.|.||.....:.. :.::...:..:..::|....||...|:.:..|::..|.....:.
  Fly   676 SVDKMLAREWLHANHKRL-VTVKFGPEAAIYTVDRKGEKLRTFSLKHIDVVSVEESATNHIKKKP 739

Human   706 -LLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFR-----KAVTKQQR 764
             :||::|.::||||...|...|..||::|.||     |.||..||:..|:.|     :|.|:::|
  Fly   740 YILLRVPSDHDLVLELESYGARRKFVKKLEDF-----LLLHKKEMTLMEVNRDIMLARAETRERR 799

Human   765 ERILEIFFRHLFAQVLDI------NQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMF 823
            ::.||.|||..:|....:      .::||     .|..:|...:...||:||||.:||:||.|||
  Fly   800 QKRLEYFFREAYALTFGLRPGERRRRSDA-----SSDGEVMTVMRTSLSKAEFAAALGMKPNDMF 859

Human   824 VESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFI 888
            |..||::.|||.:|.:||:|||:.:|:|.:|..:||.|::|.|.|.|.||.:.|.|...||||.:
  Fly   860 VRKMFNIVDKDQDGRISFQEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLV 924

Human   889 EIS-NNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGI 952
            ||: ...|...|:.|:::.||::.|.:.|..||::||..|::::..:.....|..||.
  Fly   925 EIARTTSLGDDQVTELIDGMFQDVGLEHKNHLTYQDFKLMMKEYKGDFVAIGLDCKGA------- 982

Human   953 RDIFKQNI---SCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEA 1014
                |||.   |..|:.:|                                        ....|.
  Fly   983 ----KQNFLDTSTNVARMT----------------------------------------SFNIEP 1003

Human  1015 LQEKMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVG 1079
            :|:| .|.:|..|...|..|:|..|::|..:.:|..:.:.:|.:|..:|.|.:..:|:.....||
  Fly  1004 MQDK-PRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVG 1067

Human  1080 IILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAG 1144
            |.::||:|||:||.:|.:||||.|||||.|:|..:.:|:|.|:.:.||:..|..|:..::||:.|
  Fly  1068 IAITRGSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVG 1132

Human  1145 HAVNVYIFSVSPLSLLACIFPNV-FVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASH 1208
            |.||.|..|......|.|:...| |.:|   ......:|.||||.|.|||:|.:::.|::|||..
  Fly  1133 HIVNFYHVSTQSHENLRCLTREVHFASD---YKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHP 1194

Human  1209 HFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGDKLVSLSRKKVEIS 1273
            ..|::::..||..|.|||.||.|.:|||...|...|.|.::||.|.|:|..||:|||..|.:.:.
  Fly  1195 TIRKKAYNFFWNMHTLYIGLYLLSLIHGLARLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYMALD 1259

Human  1274 VVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGP 1338
            |:..:||||.|..::|.||...:|.||||||::|.|....|.|.|||||||||:.||.||:|.||
  Fly  1260 VIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHENFLSCHIKAQGP 1324

Human  1339 WTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKS 1403
            ||.:||. |..|........||:.::||||.|:|:|:||||:|:|||||||||:||||.||||.:
  Fly  1325 WTWKLRN-YFDPCNYNPEDQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGT 1388

Human  1404 SLG--SQMLCKKIYFIWVTRTQRQFEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLY 1466
            |..  |.:.|||:||:|:..:.:.|||..|::::||:.|..:::.:||::||...||||||||||
  Fly  1389 STNRYSGVACKKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLY 1453

Human  1467 ICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQ 1531
            |||.|||::...|:||||:::.|||||....|...:|:.|..|.|||||||||..:||:|..||.
  Fly  1454 ICENHFQRLSKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACD 1518

Human  1532 LVNRQDR-AHFMHHYENF 1548
            .||:..: .:|:||:|||
  Fly  1519 EVNKTRKLPYFIHHFENF 1536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUOX2	NP_001350640.1	Peroxidase-like, mediates peroxidase activity. /evidence=ECO:0000250	30..596		235/569 (41%)
		dual_peroxidase_like	38..594	CDD:188652	230/559 (41%)
		EFh_PEF	<764..858	CDD:330173	39/99 (39%)
		EFh	824..885	CDD:238008	27/60 (45%)
		EF-hand_7	857..929	CDD:316058	29/72 (40%)
		Interaction with TXNDC11. /evidence=ECO:0000250	960..1245		90/288 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..991		0/19 (0%)
		Ferric_reduct	1088..1223	CDD:307763	53/135 (39%)
		NOX_Duox_like_FAD_NADP	1274..1548	CDD:99783	142/276 (51%)
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139	215/516 (42%)
		dual_peroxidase_like	72..625	CDD:188652	230/559 (41%)
		EFh	827..882	CDD:238008	28/59 (47%)
		EFh	860..921	CDD:238008	27/60 (45%)
		EF-hand_7	860..920	CDD:290234	26/59 (44%)
		EFh	895..966	CDD:238008	28/70 (40%)
		EF-hand_7	899..965	CDD:290234	25/65 (38%)
		Ferric_reduct	1084..1217	CDD:280043	54/135 (40%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	141/271 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	428	1.000	Domainoid score	I599
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9689
Inparanoid	1	1.050	1087	1.000	Inparanoid score	I242
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46390
OrthoDB	1	1.010	-	-		D19296at33208
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	1	1.000	-	-		otm41000
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	1	1.100	-	-	LDO	PTHR11972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R458
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870