Protein Alignment MINK1 and msn

DIOPT Version :10

• Sequence 1: XP_006721594.1
• Gene: MINK1 / 50488
• HGNCID: 17565
• Length: 1361
• Species: Homo sapiens
• Sequence 2: NP_524679.3
• Gene: msn / 44030
• FlyBaseID: FBgn0010909
• Length: 1504
• Species: Drosophila melanogaster
• Alignment Length: 1580
• Identity: 702/1580 - (44%)
• Similarity: 889/1580 - (56%)
• Gaps: 308/1580 - (19%)

Human     4 PAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQ 68
            |:...|||||||:||:||||||||:||||||||||||||||.||||||||||||||||||||||.
  Fly    11 PSVNCSLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKL 75

Human    69 EINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYI 133
            |||:|||||:||||||||||||||||||.|||||||||:|||||||||||:|||.:|||:.||||
  Fly    76 EINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYI 140

Human   134 CREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
            ||||||||::||::|||||||||||||||:||||||||||||||||||:||||||||||||||||
  Fly   141 CREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPE 205

Human   199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFI 263
            |||||||||||||.|||:|||||||:||||..|||||:||||||||||||.|||||||||||||.
  Fly   206 VIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFH 270

Human   264 DFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEE 328
            .||||.|:|.|..||.||.|||..||:||||:|||||||||||||.:|::.|||..:|.||||:.
  Fly   271 GFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDN 335

Human   329 EDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393
            :||.....||.|||:..||..||||.|.::|:    ...|.:||||.....|...:|...|...|
  Fly   336 DDDEPQLAGEHSSIVQAPGGDTLRRNFQQIQE----GRLAAEQQQQHHLMAQAQAQAAAAHAAAQ 396

Human   394 RQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE--ERRQAEREQEYIRHRL 456
            .|.::::|:::............:|  .|:..||.:.:..||.|:.:  .|:|.|......|
  Fly   397 AQAQLQQQQQQAAAAAAAAAHAAQQ--AQQAAQQAQAQQPQANRQPKPPSRQQVEEPGPPAR--- 456

Human   457 EEEQRQLEILQQQLLQEQALLLEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQ--- 518
             ..||.:.:.........   |....|..|...|:.: |:|...::.:..||..::.:.|.|
  Fly   457 -PPQRLIVVPDPPHANRP---LPPTPKCGEPAGQTPQ-QQQRNSQNNFKPSLPPRRPEPQPQTAA 516

Human   519 --KQQQQQLLP------------------------GDRKPL--------YHYGRGMNP------A 543
              :..|||..|                        |..||.        .|.|:.:||      :
  Fly   517 GGQGSQQQAQPEAPPRNNRQSSGLSSSGGSASGGGGSSKPAAALPQQSNNHLGQPVNPLDPLDSS 581

Human   544 DKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEP---------------PIPQASPGPPG-PLS 592
            |..:...|..:|.|    .:..|..|.|    |:|               |:...|.|||. ||.
  Fly   582 DSDSEPDEPNDRAR----NDGTLLASDP----PKPLPGLGPVSEDANTTTPLSHGSGGPPNRPLP 638

Human   593 QTPP-----------MQRPVEPQ----------------------------------------EG 606
            .||.           |:|.:|..                                        .|
  Fly   639 PTPDDDDQAGDRTLIMKRKLEQNINRLQKSASTSQANVTPSRRGDESNLLRDWDFDRFFPKNANG 703

Human   607 PHKS----------------LVAHRVPLKPYAA--------PVPRS-QSLQDQPTRNLAAFPASH 646
            |..|                |...:|..|...|        ||||. |.|:.:|:   |:...:.
  Fly   704 PRGSGRGSPTTTASLSRSSQLSTLKVDTKLQRASVAEAITRPVPRGYQPLKAEPS---ASQSIAK 765

Human   647 DPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVP------------- 698
            :...|..:.:.:.||.|:           |.|.|.|.||..|.|:::  ::|
  Fly   766 EQGSASGSGSGSGSASGS-----------GSGGSTNSPAHKRQDSDS--RLPTNFERGFRRENSD 817

Human   699 -----QRTSSIATALNTSGA-GGSRPAQAVRARPRSNSAWQ---IY----LQRRAERGTPKPPGP 750
                 :|.|::.:..:.||: .||..|||::   ||::.:|   ||    ..:..|...|..||
  Fly   818 FFPLAKRYSAVFSGASASGSTAGSPSAQALQ---RSSAVYQRNSIYSSSISSKSKENDVPGAPG- 878

Human   751 PAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNK 815
             |...|...||:.|.         .:.:...|:.|..|:.                       :|
  Fly   879 -AAAAGTATASAKPG---------PAAATTTATKGAAPKT-----------------------SK 910

Human   816 AKPDDHRSRPGRPADFVLLKERT-----LDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAE 875
            :..:.|..||.|        |:|     |..|....::........::.:..:..:::..||...
  Fly   911 SLANFHFLRPRR--------EKTESVIVLQNAAVRAQRLQQLQQQQQQQQLQQQQQQQNRGGGGG 967

Human   876 GSRDTPGGRSDG---DTDSVST------MVVHD-VEEITGTQPP---------YGGG-TMVVQRT 920
            |.....||.|.|   |...:.|      .|:.| :.:.:...||         |... :..|..|
  Fly   968 GGGGGGGGGSSGVGADGTGLGTPGTRTSSVLPDLLSQASPATPPRHDKSSSEEYQAAISSSVHST 1032

Human   921 PEEERNLLHADSNGYTNLPD-------VVQPSHSP---------TENSKGQSPPSKDGSGDYQSR 969
            |  .::.:.:..:|...|..       ::..:|||         :.||: |:.|....|....|.
  Fly  1033 P--SKSFIASSGSGGLGLGGGTVVGGVIISSNHSPQSTISLASSSSNSR-QNSPKNSISKTRSSS 1094

Human   970 GLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDV-------------RKG 1021
            .:.....||:.:...:|....|..|..|..|:..:......|.|.|...             |:.
  Fly  1095 SITNLLHKSASSSSANLHHLTPCSSTSSASISNPLPPHAYALQQKQRSFLTFGFGAGGSGPSRRE 1159

Human  1022 SVVNVN--PTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLI 1084
            |.||||  ||:..|.::||||||||||||||||||||||||||:||||||||||||||||||.||
  Fly  1160 SHVNVNVTPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLI 1224

Human  1085 GRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHND---PEVEKKQGWTTVGDMEGCG 1146
            .|||||||:||||.|:|:|||||:|::||||||||::|||..|   .:||::.||..|||::|..
  Fly  1225 SRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVGDLQGAV 1289

Human  1147 HYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYG 1211
            |:::||||||||||||||.|:|:|||||||||||||||:|.:|.|||||||||:|:..|||||||
  Fly  1290 HFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLKVIYG 1354

Human  1212 SSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDV 1276
            |:.||||||:||...||||:|.|.|..|.||.|:.|||::||::||||::|||||||.||:.|::
  Fly  1355 SAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNI 1419

Human  1277 VLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1341
            ||||||||||||||.:.||||||.|||||||||:||||||||||:||||||||||||||||:|.:
  Fly  1420 VLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAK 1484

Human  1342 SGGSSQVYFMTLNRNCIMNW 1361
            ...|.|:||||||:..:.||
  Fly  1485 GASSCQIYFMTLNKPGMANW 1504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MINK1	XP_006721594.1	STKc_MAP4K4_6_N	8..289	CDD:270806	241/280 (86%)
		PHA03307	537..>849	CDD:223039	87/440 (20%)
		CNH	1043..1341	CDD:214481	225/300 (75%)
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	233/270 (86%)
		CNH	1183..1484	CDD:214481	225/300 (75%)