DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCAL1 and STH1

DIOPT Version :10

Sequence 1:NP_054859.2 Gene:SMARCAL1 / 50485 HGNCID:11102 Length:954 Species:Homo sapiens
Sequence 2:NP_012140.1 Gene:STH1 / 854680 SGDID:S000001388 Length:1359 Species:Saccharomyces cerevisiae


Alignment Length:561 Identity:139/561 - (24%)
Similarity:232/561 - (41%) Gaps:114/561 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   436 LMPFQRAGVNFAIAKGGRLL---LADDMGLGKTIQAICIAAF---YRKE-WPLLVVVPSSVRFTW 493
            |..:|..|:.:.::.....|   |||:||||||||:|.:..:   .:|: .|.||:||.|....|
Yeast   470 LKEYQLRGLEWMVSLYNNHLNGILADEMGLGKTIQSISLITYLYEVKKDIGPFLVIVPLSTITNW 534

Human   494 EQAFLRWLPSLSPDCINVVVTGKDRLTAGL---INIVSFDLLSKL------EKQL--KTPFKVVI 547
            ...|.:|.|||:    .::..|.......|   |.:.:||:|...      :|.|  |..:..:|
Yeast   535 TLEFEKWAPSLN----TIIYKGTPNQRHSLQHQIRVGNFDVLLTTYEYIIKDKSLLSKHDWAHMI 595

Human   548 IDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRY 612
            |||.|.:||:::..........:...|:| |:|||..:...||:..:..|.|..|.....|.   
Yeast   596 IDEGHRMKNAQSKLSFTISHYYRTRNRLI-LTGTPLQNNLPELWALLNFVLPKIFNSAKTFE--- 656

Human   613 CDAKRMPWGWDYSGSSNLG---ELKLLLEEAV-------------MLRRLKSDVLSQLPAKQRKI 661
                    .|..:..:|.|   :|:|..||.:             :|||||.:|...||.|..|:
Yeast   657 --------DWFNTPFANTGTQEKLELTEEETLLIIRRLHKVLRPFLLRRLKKEVEKDLPDKVEKV 713

Human   662 VVIAPGRIN-------ARTRAALDAAAKEMTTK-------DKTKQQQKDALILF-FNRTAEAKIP 711
            :......:.       .:..|....|..|..||       :|..|.:|.....| |:.......|
Yeast   714 IKCKLSGLQQQLYQQMLKHNALFVGAGTEGATKGGIKGLNNKIMQLRKICNHPFVFDEVEGVVNP 778

Human   712 S---------------VIEYILDLLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSS 761
            |               :::.:|...::...:.|:|.....|:|.:...|..|.::::|:||||.:
Yeast   779 SRGNSDLLFRVAGKFELLDRVLPKFKASGHRVLMFFQMTQVMDIMEDFLRMKDLKYMRLDGSTKT 843

Human   762 AEREDLCQQFQLSER-HAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTS 825
            .||.::...|...:. :...:||..|..:||...:||.|:..:..|||...:||:||.|||||.:
Yeast   844 EERTEMLNAFNAPDSDYFCFLLSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKN 908

Human   826 SVGIHYLVAKGTADDYLWPLIQEKIKV---LAEAGL-------------------SETNFS---- 864
            .|.|..|:...:.::.:.....:|:.:   :.:||.                   ||||..    
Yeast   909 EVRILRLITTDSVEEVILERAMQKLDIDGKVIQAGKFDNKSTAEEQEAFLRRLIESETNRDDDDK 973

Human   865 ---EMTESTDYLYKDPKQQKIYDLFQKSFEKEGSDMELLEA 902
               :..|..|.|.:...::.::|    ..:||..:.|..:|
Yeast   974 AELDDDELNDTLARSADEKILFD----KIDKERMNQERADA 1010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCAL1NP_054859.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198 5..30
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..238
HARP 248..302 CDD:462166
HARP 343..397 CDD:462166
HepA <423..856 CDD:440319 125/487 (26%)
DEXHc_HARP_SMARCAL1 436..645 CDD:350768 65/242 (27%)
DESH box 549..552 2/2 (100%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831 644..661 8/16 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 904..934
STH1NP_012140.1 HSA 312..378 CDD:462194
PLN03142 370..>955 CDD:215601 127/500 (25%)
SnAC 1006..1069 CDD:464219 2/5 (40%)
COG5076 <1211..>1359 CDD:227408
Blue background indicates that the domain is not in the aligned region.

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