Protein Alignment SMARCAL1 and ISW2

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_014948.1
• Gene: ISW2 / 854480
• SGDID: S000005831
• Length: 1120
• Species: Saccharomyces cerevisiae
• Alignment Length: 755
• Identity: 171/755 - (22%)
• Similarity: 294/755 - (38%)
• Gaps: 212/755 - (28%)

Human   340 RAYFEADISYSQDLIALFKQMD---------------SRRYDVKTRKWSFLLEEHSKLIA--KVR 387
            |.:......:.:::..|.||:|               |.|:..||.|     ||.::|:|  :..
Yeast   102 RHFIGIKAKHDKNIQKLLKQLDSDANKLSKSHSTVSSSSRHHRKTEK-----EEDAELMADEEEE 161

Human   388 CLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVSN--LMPFQRAGVNFAIAK 450
            .:...|.|        .|.|:                    .|..|.:  |..:|..|:|:.|:.
Yeast   162 IVDTYQED--------IFVSE--------------------SPSFVKSGKLRDYQVQGLNWLISL 198

Human   451 GGRLL---LADDMGLGKTIQAICIAAFYRK----EWPLLVVVPSSVRFTWEQAFLRWLPSLSPDC 508
            ....|   |||:||||||:|.|....:.|.    |.|.|::||.|....|.:.||:|.|:
Yeast   199 HENKLSGILADEMGLGKTLQTISFLGYLRYVKQIEGPFLIIVPKSTLDNWRREFLKWTPN----- 258

Human   509 INVVVTGKDRLT-AGLIN-----------IVSFDLLSKLEKQLK-TPFKVVIIDESHFLKNSRTA 560
            :||:|...|:.| |.::.           |.|::::.:.:..|| ..::.::|||:|.:||.::|
Yeast   259 VNVLVLHGDKDTRADIVRNIILEARFDVLITSYEMVIREKNALKRLAWQYIVIDEAHRIKNEQSA 323

Human   561 RCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYS 625
            ..:...  |..:|..:|::|||..:...||:..:..:.|..|.....|.         .| ::.:
Yeast   324 LSQIIR--LFYSKNRLLITGTPLQNNLHELWALLNFLLPDIFGDSELFD---------EW-FEQN 376

Human   626 GSSNLGELKLLLEEAV----MLRRLKSDV-LSQLPAKQRKIVVIAPGRINARTRAALDAAAKEMT 685
            .|....|:.:....:|    :|||:|:|| .|.||..:..:.|   |..:.:.:.......|::.
Yeast   377 NSEQDQEIVIQQLHSVLNPFLLRRVKADVEKSLLPKIETNVYV---GMTDMQIQWYKSLLEKDID 438

Human   686 TKDKT--KQQQKDALI------------------------------LFFNRTAEAKIPSVIEYIL 718
            ..:..  |::.|..|:                              |.||   ..|: .:::.:|
Yeast   439 AVNGAVGKREGKTRLLNIVMQLRKCCNHPYLFEGAEPGPPYTTDEHLIFN---SGKM-IILDKLL 499

Human   719 DLLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL--SERHAVAV 781
            ..|:....:.|:|:....:||.:......:..::.|||||||..||.:...::..  ||:. |.:
Yeast   500 KRLKEKGSRVLIFSQMSRLLDILEDYCYFRDFEYCRIDGSTSHEERIEAIDEYNKPNSEKF-VFL 563

Human   782 LSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAK----------- 835
            |:..|..:|:...:||.|:..:..|||...:||.||.|||||...|.::..|.:
Yeast   564 LTTRAGGLGINLVTADTVILFDSDWNPQADLQAMDRAHRIGQKKQVHVYRFVTENAIEEKVIERA 628

Human   836 ----------------------GTADDYLWPLIQ-------EK--IKVLAEAGL----------- 858
                                  |.:.|.|..:||       ||  .||..:|.:
Yeast   629 AQKLRLDQLVIQQGTGKKTASLGNSKDDLLDMIQFGAKNMFEKKASKVTVDADIDDILKKGEQKT 693

Human   859 SETNFSEMTESTDYLYK--DPKQQKIYDLFQKSFEKEGSDMELLEAAESFDPGSASGTSGSSSQN 921
            .|.|....:...|.|.|  ..:.|..|:...|||:|:.:|    :..|..:|.........::.:
Yeast   694 QELNAKYQSLGLDDLQKFNGIENQSAYEWNGKSFQKKSND----KVVEWINPSRRERRREQTTYS 754

Human   922 MGDTLDE-------SSLTASPQKK----------RRFEFF 944
            :.|...|       |:...:||.|          :.|:||
Yeast   755 VDDYYKEIIGGGSKSASKQTPQPKAPRAPKVIHGQDFQFF 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238
		HARP	248..302	CDD:462166
		HARP	343..397	CDD:462166	15/70 (21%)
		HepA	<423..856	CDD:440319	129/535 (24%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	62/232 (27%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		8/17 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934		5/36 (14%)
ISW2	NP_014948.1	PLN03142	1..1093	CDD:215601	171/755 (23%)