DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMARCAL1 and ISW2

DIOPT Version :9

Sequence 1:	NP_001120679.1	Gene:	SMARCAL1 / 50485	HGNCID:	11102	Length:	954	Species:	Homo sapiens
Sequence 2:	NP_014948.1	Gene:	ISW2 / 854480	SGDID:	S000005831	Length:	1120	Species:	Saccharomyces cerevisiae

Alignment Length:	755	Identity:	171/755 - (22%)
Similarity:	294/755 - (38%)	Gaps:	212/755 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   340 RAYFEADISYSQDLIALFKQMD---------------SRRYDVKTRKWSFLLEEHSKLIA--KVR 387
            |.:......:.:::..|.||:|               |.|:..||.|     ||.::|:|  :..
Yeast   102 RHFIGIKAKHDKNIQKLLKQLDSDANKLSKSHSTVSSSSRHHRKTEK-----EEDAELMADEEEE 161

Human   388 CLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVSN--LMPFQRAGVNFAIAK 450
            .:...|.|        .|.|:                    .|..|.:  |..:|..|:|:.|:.
Yeast   162 IVDTYQED--------IFVSE--------------------SPSFVKSGKLRDYQVQGLNWLISL 198

Human   451 GGRLL---LADDMGLGKTIQAICIAAFYRK----EWPLLVVVPSSVRFTWEQAFLRWLPSLSPDC 508
            ....|   |||:||||||:|.|....:.|.    |.|.|::||.|....|.:.||:|.|:
Yeast   199 HENKLSGILADEMGLGKTLQTISFLGYLRYVKQIEGPFLIIVPKSTLDNWRREFLKWTPN----- 258

Human   509 INVVVTGKDRLT-AGLIN-----------IVSFDLLSKLEKQLK-TPFKVVIIDESHFLKNSRTA 560
            :||:|...|:.| |.::.           |.|::::.:.:..|| ..::.::|||:|.:||.::|
Yeast   259 VNVLVLHGDKDTRADIVRNIILEARFDVLITSYEMVIREKNALKRLAWQYIVIDEAHRIKNEQSA 323

Human   561 RCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYS 625
            ..:...  |..:|..:|::|||..:...||:..:..:.|..|.....|.         .| ::.:
Yeast   324 LSQIIR--LFYSKNRLLITGTPLQNNLHELWALLNFLLPDIFGDSELFD---------EW-FEQN 376

Human   626 GSSNLGELKLLLEEAV----MLRRLKSDV-LSQLPAKQRKIVVIAPGRINARTRAALDAAAKEMT 685
            .|....|:.:....:|    :|||:|:|| .|.||..:..:.|   |..:.:.:.......|::.
Yeast   377 NSEQDQEIVIQQLHSVLNPFLLRRVKADVEKSLLPKIETNVYV---GMTDMQIQWYKSLLEKDID 438

Human   686 TKDKT--KQQQKDALI------------------------------LFFNRTAEAKIPSVIEYIL 718
            ..:..  |::.|..|:                              |.||   ..|: .:::.:|
Yeast   439 AVNGAVGKREGKTRLLNIVMQLRKCCNHPYLFEGAEPGPPYTTDEHLIFN---SGKM-IILDKLL 499

Human   719 DLLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL--SERHAVAV 781
            ..|:....:.|:|:....:||.:......:..::.|||||||..||.:...::..  ||:. |.:
Yeast   500 KRLKEKGSRVLIFSQMSRLLDILEDYCYFRDFEYCRIDGSTSHEERIEAIDEYNKPNSEKF-VFL 563

Human   782 LSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAK----------- 835
            |:..|..:|:...:||.|:..:..|||...:||.||.|||||...|.::..|.:
Yeast   564 LTTRAGGLGINLVTADTVILFDSDWNPQADLQAMDRAHRIGQKKQVHVYRFVTENAIEEKVIERA 628

Human   836 ----------------------GTADDYLWPLIQ-------EK--IKVLAEAGL----------- 858
                                  |.:.|.|..:||       ||  .||..:|.:
Yeast   629 AQKLRLDQLVIQQGTGKKTASLGNSKDDLLDMIQFGAKNMFEKKASKVTVDADIDDILKKGEQKT 693

Human   859 SETNFSEMTESTDYLYK--DPKQQKIYDLFQKSFEKEGSDMELLEAAESFDPGSASGTSGSSSQN 921
            .|.|....:...|.|.|  ..:.|..|:...|||:|:.:|    :..|..:|.........::.:
Yeast   694 QELNAKYQSLGLDDLQKFNGIENQSAYEWNGKSFQKKSND----KVVEWINPSRRERRREQTTYS 754

Human   922 MGDTLDE-------SSLTASPQKK----------RRFEFF 944
            :.|...|       |:...:||.|          :.|:||
Yeast   755 VDDYYKEIIGGGSKSASKQTPQPKAPRAPKVIHGQDFQFF 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_001120679.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2	2..30
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..238
		TMEM108	85..>303	CDD:318054
		HARP	248..301	CDD:311403
		HARP	343..396	CDD:311403	14/69 (20%)
		HepA	<417..889	CDD:223627	137/587 (23%)
		DESH box	549..552		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	904..934		5/36 (14%)
ISW2	NP_014948.1	PLN03142	1..1093	CDD:215601	171/755 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910