DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCAL1 and ULS1

DIOPT Version :10

Sequence 1:NP_054859.2 Gene:SMARCAL1 / 50485 HGNCID:11102 Length:954 Species:Homo sapiens
Sequence 2:NP_014834.1 Gene:ULS1 / 854363 SGDID:S000005717 Length:1619 Species:Saccharomyces cerevisiae


Alignment Length:698 Identity:143/698 - (20%)
Similarity:235/698 - (33%) Gaps:274/698 - (39%)


- Green bases have known domain annotations that are detailed below.


Human   415 SLTPDVPEADLSEVDPKLVSNLMPFQRAGVNFAI------AKGGRLLLADDMGLGKTIQAICIAA 473
            :|||:           .:..||:..||.|:::.:      .|||  |||||||||||||||.:..
Yeast   933 ALTPE-----------DMTVNLLKHQRLGLHWLLQVENSAKKGG--LLADDMGLGKTIQAIALML 984

Human   474 FYRKEWPL----LVVVPSSVRFTWE-------------QAFL----------RWLPSLSPDCINV 511
            ..|.|...    |:|.|.||...|:             ..|:          .|......|.:.|
Yeast   985 ANRSEESKCKTNLIVAPVSVLRVWKGELETKVKKRAKFTTFIFGGSGNGKVKHWRDLARYDAVLV 1049

Human   512 ---------------VVTGKDRLTAGLINIVSFDLLSKLEKQLKTPFKV-------VIIDESHFL 554
                           .:.|:......:.:|.:.:.| |...:..:||..       :::||...:
Yeast  1050 SYQTLANEFKKHWPKKLDGEQNQLPAVPHIQALNRL-KTSNEYYSPFFCNDSTFYRILLDEGQNI 1113

Human   555 KNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFH---AFGL---RYC 613
            ||..|...:|...:..:.:.|  |||||..:...|||:.|..::   .|.:|   .|.|   |:.
Yeast  1114 KNKNTRASKACCTINGMYRWV--LSGTPIQNSMDELYSLIRFLR---IPPYHKEQRFKLDIGRFF 1173

Human   614 DAKRMPWGWDYSGSSN-LGELKLLLEEAVMLRRLKSD-----VLSQLPAK--------------- 657
            ...:. :.:|.....| |.::::|| .|:||||.|:|     .|.:||.|               
Yeast  1174 QRNKQ-YQYDNEDRKNALRKVRVLL-NAIMLRRSKADKIDGKPLLELPPKIVEVDESRLKGEELK 1236

Human   658 -----QRKIVVIAPGRINARTRAAL---------------------------------------- 677
                 :.|...:|...:|..||.:.                                        
Yeast  1237 FYTALESKNQALAKKLLNNSTRGSYSSVLTLLLRLRQACCHSELVVMGEKKAEGTKVANGKSFED 1301

Human   678 ----------------------------------------------------------------- 677
                                                                             
Yeast  1302 DWLRLYYKITHMSGEAQAQVITSMNSMTCFWCMEQLEPEAMSVLTGCGHLICDTCIEPFIEESSM 1366

Human   678 ---------------------------------------------DAAAKEMTTKDKTKQQQKDA 697
                                                         |..|:.::..:|.|.|||:.
Yeast  1367 LPQAKKTKGGAFAIPCKDCQRLTNEKDIVSHKLYDQVINQGFTEEDLHAEYLSEMEKQKIQQKNV 1431

Human   698 LILFFNRTAEAKIPS--------VIEYILDLLESGREKFLVFAHHKVVLDAITQELERK-HVQHI 753
            .:..|    |:..||        ||:.:.|  ||..||.::|:......:.:...|:.| :..::
Yeast  1432 YVPNF----ESLEPSTKIEQCIQVIQRVFD--ESATEKIIIFSQFTTFFEILEHFLKNKLNFPYL 1490

Human   754 RIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRV 818
            :..||.::..|.|:..:|.......:.::|:.|.|.|||.:.|:.||..:.||||.|..||:||.
Yeast  1491 KYIGSMNAQRRSDVINEFYRDPEKRILLISMKAGNSGLTLTCANHVVIVDPFWNPYVEEQAQDRC 1555

Human   819 HRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAEAGLSETNFSEM 866
            :||.||..|.:|.|..|.:.:|.:..| |::.|.:.::.:......|:
Yeast  1556 YRISQTKKVQVHKLFIKDSVEDRISEL-QKRKKEMVDSAMDPGKIKEV 1602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCAL1NP_054859.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198 5..30
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..238
HARP 248..302 CDD:462166
HARP 343..397 CDD:462166
HepA <423..856 CDD:440319 139/678 (21%)
DEXHc_HARP_SMARCAL1 436..645 CDD:350768 69/270 (26%)
DESH box 549..552 2/2 (100%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831 644..661 8/41 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 904..934
ULS1NP_014834.1 HepA <936..1595 CDD:440319 140/686 (20%)
RING-HC_ULS1-like 1324..1403 CDD:438498 0/78 (0%)
Blue background indicates that the domain is not in the aligned region.

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