DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCAL1 and ISW1

DIOPT Version :10

Sequence 1:NP_054859.2 Gene:SMARCAL1 / 50485 HGNCID:11102 Length:954 Species:Homo sapiens
Sequence 2:NP_009804.1 Gene:ISW1 / 852547 SGDID:S000000449 Length:1129 Species:Saccharomyces cerevisiae


Alignment Length:572 Identity:144/572 - (25%)
Similarity:247/572 - (43%) Gaps:114/572 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   436 LMPFQRAGVNFAIAK-----GGRLLLADDMGLGKTIQAICIAAFYRK----EWPLLVVVPSSVRF 491
            |.|:|..|||:.::.     .|  :|||:||||||:|.|....:.|.    ..|.||:.|.|...
Yeast   196 LRPYQIQGVNWLVSLHKNKIAG--ILADEMGLGKTLQTISFLGYLRYIEKIPGPFLVIAPKSTLN 258

Human   492 TWEQAFLRWLPSLSPDCINVVVTGKDRLTAGLIN-----------IVSFDLLSKLEKQL-KTPFK 544
            .|.:...||    :||....::.|.....|.||.           |.|::::.:.:..| |..::
Yeast   259 NWLREINRW----TPDVNAFILQGDKEERAELIQKKLLGCDFDVVIASYEIIIREKSPLKKINWE 319

Human   545 VVIIDESHFLKNSRTARCRAAMPVLK--VAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHA 607
            .:||||:|.:||..:...:    ||:  .::..:|::|||..:...||:..:..:.|..|.....
Yeast   320 YIIIDEAHRIKNEESMLSQ----VLREFTSRNRLLITGTPLQNNLHELWALLNFLLPDIFSDAQD 380

Human   608 FGLRYCDAKRMPWGWDYSGSSNLGELKLLLE-----EAVMLRRLKSDV-LSQLPAKQRKIVVIAP 666
            |.           .|..|.|:...:.|::.:     :..:|||:|||| .|.||.|:..:.|   
Yeast   381 FD-----------DWFSSESTEEDQDKIVKQLHTVLQPFLLRRIKSDVETSLLPKKELNLYV--- 431

Human   667 GRINARTR-------AALDA-----AAKEMTTK--DKTKQQQKDALILFFNRTAEAKIP------ 711
            |..:.:.:       ..|||     .:||..|:  :...|.:|.....:....||...|      
Yeast   432 GMSSMQKKWYKKILEKDLDAVNGSNGSKESKTRLLNIMMQLRKCCNHPYLFDGAEPGPPYTTDEH 496

Human   712 --------SVIEYILDLLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLC 768
                    .|::.:|..|:....:.|:|:....:||.:......::.::.||||||:..:|....
Yeast   497 LVYNAAKLQVLDKLLKKLKEEGSRVLIFSQMSRLLDILEDYCYFRNYEYCRIDGSTAHEDRIQAI 561

Human   769 QQFQLSE-RHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYL 832
            ..:...: :..|.:|:..|..:|:..:|||:||..:..|||...:||.||.|||||...|.:..|
Yeast   562 DDYNAPDSKKFVFLLTTRAGGLGINLTSADVVVLYDSDWNPQADLQAMDRAHRIGQKKQVKVFRL 626

Human   833 VAKGTADDYLWPLIQEKIKVLAEAGLSETNFSEMTESTDYLYKDPK--QQKIYDLFQKSFEKEGS 895
            |...:        ::|||               :..:|..|..|..  ||....|.:|..:.:..
Yeast   627 VTDNS--------VEEKI---------------LERATQKLRLDQLVIQQNRTSLKKKENKADSK 668

Human   896 D--MELLE--AAESFDPGSASGTSGS---SSQNMGDTLDESSLTASPQKKRR 940
            |  :.:::  ||:.|..|:::|::|:   .|...||.:|...|....:.|.:
Yeast   669 DALLSMIQHGAADVFKSGTSTGSAGTPEPGSGEKGDDIDLDELLLKSENKTK 720

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCAL1NP_054859.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198 5..30
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..238
HARP 248..302 CDD:462166
HARP 343..397 CDD:462166
HepA <423..856 CDD:440319 124/477 (26%)
DEXHc_HARP_SMARCAL1 436..645 CDD:350768 60/236 (25%)
DESH box 549..552 2/2 (100%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831 644..661 10/17 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 904..934 9/32 (28%)
ISW1NP_009804.1 PLN03142 108..1057 CDD:215601 144/572 (25%)
Blue background indicates that the domain is not in the aligned region.

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