DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCAL1 and RAD16

DIOPT Version :10

Sequence 1:NP_054859.2 Gene:SMARCAL1 / 50485 HGNCID:11102 Length:954 Species:Homo sapiens
Sequence 2:NP_009672.1 Gene:RAD16 / 852411 SGDID:S000000318 Length:790 Species:Saccharomyces cerevisiae


Alignment Length:828 Identity:166/828 - (20%)
Similarity:283/828 - (34%) Gaps:286/828 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   264 TLPSKNY----DPDTKTWNFSMNDYSALMKAAQSLPTVNLQPLEWAYGSSESPSTSSEGQ----A 320
            |..|.||    |.||               |.::..|:.|:      |:||:.:.|.:.:    |
Yeast    15 TKKSVNYNELSDDDT---------------AVKNSKTLQLK------GNSENVNDSQDEEYRDDA 58

Human   321 GLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIAK 385
            .|..:|.                :.|..:..||....|:..:      |.:.:..::..:..|.:
Yeast    59 TLVKSPD----------------DDDKDFIIDLTGSDKERTA------TDENTHAIKNDNDEIIE 101

Human   386 VRCLPQVQLDPLPTT---LTLAFASQLKKTSLSLTPDV--------------PE-----ADLSEV 428
            ::....|..|..|.|   .|.|...:.|.::...:|.|              ||     .||...
Yeast   102 IKEERDVSDDDEPLTKKRKTTARKKKKKTSTKKKSPKVTPYERNTLRLYEHHPELRNVFTDLKNA 166

Human   429 DP----------KLVSNLMPFQRAGVNFAIAK------GGRLLLADDMGLGKTIQAICIAAFYRK 477
            .|          .:...|:|||..|:::.|::      ||  :|||:||:|||||.|.:......
Yeast   167 PPYVPQRSKQPDGMTIKLLPFQLEGLHWLISQEESIYAGG--VLADEMGMGKTIQTIALLMNDLT 229

Human   478 EWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVTGKDRLTAGLINIVSFDLL--------SK 534
            :.|.|||.|:.....|:..    :...:...:.:.:......|..:.::..:|::        |.
Yeast   230 KSPSLVVAPTVALMQWKNE----IEQHTKGQLKIYIYHGASRTTDIKDLQGYDVVLTTYAVLESV 290

Human   535 LEKQ----------LKTP-------FKVVIIDESHFLKN--SRTARCRAAMPVLKVAKRVILLSG 580
            ..||          .|.|       |..||:||:|.:|:  |.|||   |:..||..|| ..|||
Yeast   291 FRKQNYGFRRKNGLFKQPSVLHNIDFYRVILDEAHNIKDRQSNTAR---AVNNLKTQKR-WCLSG 351

Human   581 TPAMSRPAELYTQI--IAVKPTFFPQFHAFGLRYCDAKRMPW----------------------- 620
            ||..:|..|:|:.|  :.:.|     |..:....||.....|                       
Yeast   352 TPLQNRIGEMYSLIRFLNINP-----FTKYFCTKCDCASKDWKFTDRMHCDHCSHVIMQHTNFFN 411

Human   621 ----------GWDYSGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQRKIVV------------ 663
                      |.:..|..:...::.||:. :||||.|.:....|....|.:.|            
Yeast   412 HFMLKNIQKFGVEGPGLESFNNIQTLLKN-IMLRRTKVERADDLGLPPRIVTVRRDFFNEEEKDL 475

Human   664 ---------------IAPG----------------------------RIN---------ARTRAA 676
                           :..|                            |:|         ...:..
Yeast   476 YRSLYTDSKRKYNSFVEEGVVLNNYANIFTLITRMRQLADHPDLVLKRLNNFPGDDIGVVICQLC 540

Human   677 LDAAAKEMTTK----------------------------------------------DKTKQQQK 695
            .|.|.:.:.:|                                              |..|:|  
Yeast   541 NDEAEEPIESKCHHKFCRLCIKEYVESFMENNNKLTCPVCHIGLSIDLSQPALEVDLDSFKKQ-- 603

Human   696 DALILFFNRT----AEAKIPSVIEYILDLLESGRE-KFLVFAHHKVVLDAITQELERKHVQHIRI 755
             :::...|.:    :..||.:::|.:..|..:.|. |.:||:....:||.:...|:|...|.:::
Yeast   604 -SIVSRLNMSGKWQSSTKIEALVEELYKLRSNKRTIKSIVFSQFTSMLDLVEWRLKRAGFQTVKL 667

Human   756 DGSTSSAEREDLCQQFQLSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHR 820
            .||.|..:|::..:.|..:.:..|.::|:.|..:.|....|..|...:.:|||.|..|:.|||||
Yeast   668 QGSMSPTQRDETIKYFMNNIQCEVFLVSLKAGGVALNLCEASQVFILDPWWNPSVEWQSGDRVHR 732

Human   821 IGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVL-AEAGLSETNFSEMT 867
            |||...|.|.....:.:.:..:..|.::|..:: |.....|...|.:|
Yeast   733 IGQYRPVKITRFCIEDSIEARIIELQEKKANMIHATINQDEAAISRLT 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCAL1NP_054859.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198 5..30
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..238
HARP 248..302 CDD:462166 10/41 (24%)
HARP 343..397 CDD:462166 8/53 (15%)
HepA <423..856 CDD:440319 129/626 (21%)
DEXHc_HARP_SMARCAL1 436..645 CDD:350768 68/276 (25%)
DESH box 549..552 2/2 (100%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831 644..661 5/16 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 904..934
RAD16NP_009672.1 HepA <172..769 CDD:440319 126/615 (20%)
RING-HC_RAD16-like 536..584 CDD:438229 3/47 (6%)
Blue background indicates that the domain is not in the aligned region.

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