Protein Alignment SMARCAL1 and smarcal1

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_001072923.1
• Gene: smarcal1 / 780385
• XenbaseID: XB-GENE-493391
• Length: 942
• Species: Xenopus tropicalis
• Alignment Length: 985
• Identity: 539/985 - (54%)
• Similarity: 679/985 - (68%)
• Gaps: 104/985 - (10%)

Human     1 MSLPLTEEQRKKIEENRQKALARRAEKLLAEQHQRTSSGTSIAGNPFQAKQGPSQNFPRESCKPV 65
            ||:.|||||::|||||||:|||||||:|.|:|:.:|:...|.   |..| |.||.
 Frog     1 MSVCLTEEQKRKIEENRQRALARRAERLAAQQNSQTNRSLSA---PLNA-QIPSG---------- 51

Human    66 SHGVIFKQQNLSSSSNADQRPHDSHSFQAKGIWKKPEEMPTA------------CPGHSPRSQMA 118
            ..||:...|:::::..: :..:..::||     |.|....||            ..|:......:
 Frog    52 QQGVLPSAQSINATGTS-RAANSKYAFQ-----KSPSGGNTAPSVPGAAGNKVQAVGNRSHDSKS 110

Human   119 LT--------GISPPLAQSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPKSSQE 175
            ||        ..:.|.|||.|..|..              :|        ||.|...|.....||
 Frog   111 LTDPAKDVKGNYTVPEAQSVPSGPSN--------------AP--------NPRHLYPAGTTPGQE 153

Human   176 TPAHSS--GQPPRDAKLEAKTAKASP--SGQNISYIHSSSESVTPR--------TEGRLQQKSGS 228
            :..||:  .:|......:..|....|  |...|:..:.:.....|.        :|||.:..:||
 Frog   154 SAKHSNSYSRPEPLTACDNDTTGPGPLRSTTTITKFYGAGPGSKPAVPVSNKTVSEGRERGVTGS 218

Human   229 SVQ-----KGVNSQKGKCVRNGD-RFQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSAL 287
            :.:     |...:.:|:||::.: ||:|.:||:|||||:|||:|||||||.||.|||.:.||::|
 Frog   219 AAEAVPAKKASGATRGRCVKHAESRFRVEVGYSAELIALFKTIPSKNYDPATKMWNFGLEDYASL 283

Human   288 MKAAQSLPTVNLQPLEWAYGSSESPSTSSEGQAGL------------PSAPSLSFVKGRCMLISR 340
            |...|.|.:|.|:.||...|...:|..::.|...:            |||.    ::|||:|:||
 Frog   284 MSEVQQLQSVELKALEGMEGVQIAPPPATGGGTNINALLAMCNNWQRPSAT----LRGRCILVSR 344

Human   341 AYFEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIAKVRCLPQVQLDPLPTTLTLAF 405
            :.||.:|.|..::|.|||||::|.||.|||||||:||::.||:..||.:.||:::|||..:..||
 Frog   345 SRFEMEIGYHAEIIGLFKQMNTRNYDTKTRKWSFMLEDYQKLMESVRNIQQVEVEPLPRPVLQAF 409

Human   406 ASQLKKTSLSLTPDVPEADLSEVDPKLVSNLMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQAIC 470
            |.|..||:: :..::||.|||:||.||.||||||||.|||||:::.|||||||||||||||||||
 Frog   410 APQFGKTTI-IREEIPEVDLSQVDSKLGSNLMPFQRDGVNFAVSREGRLLLADDMGLGKTIQAIC 473

Human   471 IAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVTGKDRLTAGLINIVSFDLLSKL 535
            |||:||||||||||.||||||||.:||.|||||:.|:.:||:|||:|..:|.||||||||||.|:
 Frog   474 IAAYYRKEWPLLVVAPSSVRFTWAEAFQRWLPSIRPESVNVIVTGRDSQSASLINIVSFDLLGKM 538

Human   536 EKQLKTPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPT 600
            :||:...|:|:||||||||||.:||||:||||:||.||||:||||||||||||||||||.||:|:
 Frog   539 DKQIAATFQVIIIDESHFLKNVKTARCKAAMPLLKSAKRVMLLSGTPAMSRPAELYTQIAAVRPS 603

Human   601 FFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQRKIVVIA 665
            |||:||.||:||||||:|||||||||||||.||||||||::|:|||||:|||||||||||:||:|
 Frog   604 FFPRFHDFGIRYCDAKQMPWGWDYSGSSNLNELKLLLEESIMIRRLKSEVLSQLPAKQRKMVVVA 668

Human   666 PGRINARTRAALDAAAKEMTTKDKTKQQQKDALILFFNRTAEAKIPSVIEYILDLLESGREKFLV 730
            |..|.|:|:|||.||||||....|:|.|:|:||:||:||||||||.||:|||:||||||||||||
 Frog   669 PEGITAKTKAALAAAAKEMAKGFKSKVQEKEALLLFYNRTAEAKIRSVLEYIMDLLESGREKFLV 733

Human   731 FAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMGLTFSS 795
            |||||:|||.|.:||.:|.|.:|||||:||||:|:.||.:||:||:..||||||||||||||.||
 Frog   734 FAHHKLVLDHICEELGKKDVPYIRIDGNTSSADRQSLCHKFQMSEKSCVAVLSITAANMGLTLSS 798

Human   796 ADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAEAGLSE 860
            ||||||||||||||||||||||||||||||||.||||||||||||||||:||||||||.:|||||
 Frog   799 ADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVNIHYLVAKGTADDYLWPMIQEKIKVLGQAGLSE 863

Human   861 TNFSEMTESTDYLYKDPKQQKIYDLFQKSFEKEGSDME-----LLEAAESFDPGSA--SGTSGSS 918
            .||||.||||||.||||||:.||||||:||.:||::..     ||||.|..|.|.|  |.|..|.
 Frog   864 ANFSETTESTDYFYKDPKQKTIYDLFQRSFSEEGAETNADEALLLEACEEADLGDAVCSPTDYSG 928

Human   919 SQNMGDTLDE 928
            :......:||
 Frog   929 NSCKRRKIDE 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		14/18 (78%)
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30		20/24 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238		49/247 (20%)
		HARP	248..302	CDD:462166	32/53 (60%)
		HARP	343..397	CDD:462166	28/53 (53%)
		HepA	<423..856	CDD:440319	336/432 (78%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	161/208 (77%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		15/16 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934		9/27 (33%)
smarcal1	NP_001072923.1	PTZ00436	<7..205	CDD:185616	60/239 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..214		49/231 (21%)
		HARP	244..298	CDD:462166	32/53 (60%)
		HARP	347..401	CDD:462166	28/53 (53%)
		DEXHc_HARP_SMARCAL1	439..648	CDD:350768	161/208 (77%)
		DESH box	552..555		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NZC9	647..664		15/16 (94%)
		SF2_C_SNF	711..836	CDD:350180	100/124 (81%)