Protein Alignment SMARCAL1 and smarcal1

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: XP_073768103.1
• Gene: smarcal1 / 560412
• ZFINID: ZDB-GENE-041210-303
• Length: 810
• Species: Danio rerio
• Alignment Length: 919
• Identity: 477/919 - (51%)
• Similarity: 610/919 - (66%)
• Gaps: 120/919 - (13%)

Human     1 MSLPLTEEQRKKIEENRQKALARRAEKLLAEQHQRTSSGTSIAGNPFQAKQGPSQNFPRESCKPV 65
            ||:.||.||:::|||||::|||||||:    |.|             .|..||:||...:|..|.
Zfish     1 MSVSLTPEQQRRIEENRKRALARRAER----QAQ-------------IADPGPAQNKHTQSGGPG 48

Human    66 SHGVIFKQQNLSSSSNADQRPHDSHSFQAKGIWKKPEEMPTACPGHSPRSQMALTGISPPLAQSP 130
            :.|...|              ::.|....:|            ...:|..|..|..|:....::.
Zfish    49 TTGGPAK--------------NNQHFASDRG------------QSGAPTRQTQLIDINAACTKTA 87

Human   131 PEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPKSSQETPAHSSGQPPRDAKLEAKTA 195
            |                              ||....|...||....|   |:|
Zfish    88 P------------------------------PTSVTAASTASSFYGQA---GKP----------- 108

Human   196 KASPSGQNISYIHSSSESVTPRTEGRLQQKSGSSVQKGVNSQKGKCVRNGD-RFQVLIGYNAELI 259
                         |:.|...|:.   |:..:....:|...|.:|:||.:.: ||:|.:||:|:||
Zfish   109 -------------STGEKRPPKP---LEPAAHIPAKKPAVSLRGRCVSHSENRFRVEVGYHADLI 157

Human   260 AVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPLEWAYGSSESPST-SSEGQAGLP 323
            .|||::|||||||.||.||||:.||..||:....||:::|:|||...|.:.|.|| ..:..|.:|
Zfish   158 LVFKSIPSKNYDPATKMWNFSLEDYQMLMEQVAHLPSISLKPLEGMEGLNISASTCRPKDAAAMP 222

Human   324 SAPSL--------SFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHS 380
            :...|        :.:||:|:|:||:..|.||.|..|:|.:||||.|:.||:|||||:||||::.
Zfish   223 ALMRLCQGWQKPGATIKGKCVLVSRSRLEVDIGYQADVIGIFKQMPSKSYDMKTRKWTFLLEDYG 287

Human   381 KLIAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVSNLMPFQRAGVN 445
            ||:|.:..||.|:.:|||..:..:|:||.:||. |..|..||||||.:||:|..:||||||.|||
Zfish   288 KLMADLNELPTVETEPLPHAVLQSFSSQFEKTE-SRAPVPPEADLSHIDPQLTRSLMPFQRDGVN 351

Human   446 FAIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCIN 510
            ||:::.||||||||||||||:|||||||:||.|||||||.||||||||.:||.|||||:.||.||
Zfish   352 FAVSREGRLLLADDMGLGKTVQAICIAAYYRSEWPLLVVAPSSVRFTWAEAFRRWLPSVKPDSIN 416

Human   511 VVVTGKDRLTAGLINIVSFDLLSKLEKQ-LKTPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKR 574
            |||.|||.|.:|||||:|:|||:|::|| ..:||.|:|:||||||||.:|||||||:|:||.|||
Zfish   417 VVVKGKDNLRSGLINIISYDLLNKMDKQPPSSPFNVIIMDESHFLKNMKTARCRAALPLLKTAKR 481

Human   575 VILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEE 639
            ||||||||||||||||||||.||:|..||:||.||.||||||::|||||||.||||.||||||||
Zfish   482 VILLSGTPAMSRPAELYTQIQAVRPALFPRFHDFGTRYCDAKQLPWGWDYSSSSNLTELKLLLEE 546

Human   640 AVMLRRLKSDVLSQLPAKQRKIVVIAPGRINARTRAALDAAAKEMTTKDKTKQQQKDALILFFNR 704
            ::|||||||:|||||||||||:|.:....||:||:|||:|||:|:......|.|:|:||::|||.
Zfish   547 SLMLRRLKSEVLSQLPAKQRKVVTVTTDGINSRTKAALNAAARELAKGYHNKSQEKEALLVFFNH 611

Human   705 TAEAKIPSVIEYILDLLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQ 769
            ||||||.:::|||.|:||.||||||||||||:|||:||:||..|.:..|||||||.||||:.||:
Zfish   612 TAEAKIRAIMEYISDMLECGREKFLVFAHHKLVLDSITKELGEKSISFIRIDGSTPSAERQLLCE 676

Human   770 QFQLSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVA 834
            :||.|::..||||||||||||||..||.||||||||||||||||||||||||||||:|.||||||
Zfish   677 RFQASQQSCVAVLSITAANMGLTLHSAALVVFAELFWNPGVLIQAEDRVHRIGQTSNVDIHYLVA 741

Human   835 KGTADDYLWPLIQEKIKVLAEAGLSETNFSEMTESTDYLYKDPKQQKIYDLFQKSFEKEGSDMEL 899
            ||||||||||:||.|:.||.:.||||:|.||..||..:..:|.:|..|.::||:||:::    |:
Zfish   742 KGTADDYLWPMIQAKMNVLEQVGLSESNISENAESASFHSRDRQQLTITEMFQRSFDED----EM 802

Human   900 LEAAESFDP 908
            |...:. ||
Zfish   803 LALMDQ-DP 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		11/18 (61%)
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30		16/24 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238		32/210 (15%)
		HARP	248..302	CDD:462166	30/53 (57%)
		HARP	343..397	CDD:462166	28/53 (53%)
		HepA	<423..856	CDD:440319	317/433 (73%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	160/209 (77%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		15/16 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934		2/5 (40%)
smarcal1	XP_073768103.1	None