Protein Alignment SMARCAL1 and Smarcal1

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_061287.2
• Gene: Smarcal1 / 54380
• MGIID: 1859183
• Length: 910
• Species: Mus musculus
• Alignment Length: 966
• Identity: 686/966 - (71%)
• Similarity: 773/966 - (80%)
• Gaps: 70/966 - (7%)

Human     1 MSLPLTEEQRKKIEENRQKALARRAEKLLAEQHQRTSSGTSIAGNPFQAKQGPSQNFPRESCKPV 65
            ||||||||||||||||||||||||||| |:||.|..:||:|.|| |.|:|||...|...|..|||
Mouse     1 MSLPLTEEQRKKIEENRQKALARRAEK-LSEQPQSAASGSSAAG-PSQSKQGSLLNLLAEPSKPV 63

Human    66 SHGVIFKQQNLSSSSNADQRPHDSHSFQ------AKGIWKKPEEMPTACPGHSPRSQMALTGISP 124
            .|..||||||||:|...|||||.|...|      ..|:||...||.||||..:|
Mouse    64 GHASIFKQQNLSNSFPTDQRPHSSRCSQPSPAEETTGLWKTQGEMSTACPKPNP----------- 117

Human   125 PLAQSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPKSSQETPAHSSGQPPRDAK 189
                |||....|.||.|:..:|                      :|:::.:|.|.|||..|||.:
Mouse   118 ----SPPGASNQPLLGYKSSEG----------------------QPQATWDTGASSSGPFPRDPE 156

Human   190 LEAKTAKASPSGQNIS---YIHSSSESVTPRTEGR----LQQKSGSSVQKGVNSQKGKCVRNGDR 247
            ||||.|:.|.|.|:||   |:....   |||||||    ||     :..:.....:|.|::.|||
Mouse   157 LEAKAARPSTSRQSISDSFYVLGGK---TPRTEGRPPNILQ-----TTPQNTGFLRGACIKTGDR 213

Human   248 FQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPLEWAYGSSESP 312
            |:|.||||.|||||||:|||::||..||||:|||:||.|||||.:.|.||:|:||:.|.|
Mouse   214 FRVKIGYNQELIAVFKSLPSRHYDSFTKTWDFSMSDYRALMKAVERLSTVSLKPLDEAGG----- 273

Human   313 STSSEGQAGLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLE 377
              |..||..|||||||:||.|:||||||..||.||.||:.:|.|||||:||.||:||||||||||
Mouse   274 --SVGGQTSLPSAPSLTFVTGKCMLISRVRFEVDIGYSEAVIGLFKQMESRSYDIKTRKWSFLLE 336

Human   378 EHSKLIAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVSNLMPFQRA 442
            ||:||||:.|.|.||||||||.|:||||||||:|||..|..||||||||.||.||||:||||||.
Mouse   337 EHNKLIARSRELKQVQLDPLPKTVTLAFASQLEKTSPKLKADVPEADLSGVDAKLVSSLMPFQRE 401

Human   443 GVNFAIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPD 507
            ||:|||:|.||||||||||||||:||||||||||||||||||||||||||||||||||||||||:
Mouse   402 GVSFAISKRGRLLLADDMGLGKTVQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPE 466

Human   508 CINVVVTGKDRLTAGLINIVSFDLLSKLEKQLKTPFKVVIIDESHFLKNSRTARCRAAMPVLKVA 572
            .||||||||.||||||:||||||||.|||:|||||||||||||||||||.:|||||||:|:||||
Mouse   467 NINVVVTGKGRLTAGLVNIVSFDLLCKLERQLKTPFKVVIIDESHFLKNIKTARCRAAVPILKVA 531

Human   573 KRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLL 637
            |||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
Mouse   532 KRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRLPWGWDYSGSSNLGELKLLL 596

Human   638 EEAVMLRRLKSDVLSQLPAKQRKIVVIAPGRINARTRAALDAAAKEMTTKDKTKQQQKDALILFF 702
            |||:|||||||||||||||||||:||:.||||::|.:|||||||||| ||||||||||:||::||
Mouse   597 EEAIMLRRLKSDVLSQLPAKQRKMVVVNPGRISSRAKAALDAAAKEM-TKDKTKQQQKEALLVFF 660

Human   703 NRTAEAKIPSVIEYILDLLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDL 767
            |||||||||.|:|||||||:||||||||||||||:|||:.:|||||:||||||||||.||:||..
Mouse   661 NRTAEAKIPCVVEYILDLLDSGREKFLVFAHHKVILDAVAKELERKNVQHIRIDGSTPSADREAQ 725

Human   768 CQQFQLSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYL 832
            ||:||||:.|.||:|||||||||||||:|||||||||||||||||||||||||||||:||.||||
Mouse   726 CQRFQLSKGHTVALLSITAANMGLTFSTADLVVFAELFWNPGVLIQAEDRVHRIGQTNSVSIHYL 790

Human   833 VAKGTADDYLWPLIQEKIKVLAEAGLSETNFSEMTESTDYLYKDPKQQKIYDLFQKSFEKEGSDM 897
            |||||||||||||||||||||.||||||||||||||:|||::|||||:.||||||:|||.:|:||
Mouse   791 VAKGTADDYLWPLIQEKIKVLGEAGLSETNFSEMTEATDYVHKDPKQKTIYDLFQQSFEDDGNDM 855

Human   898 ELLEAAESFDPGSASGTSGSSSQNMGDTLDESSLTASPQKKRRFEFFDNWDSFTSP 953
            |.|||||||:.||.|||||:.||::||.|||..  .||.||.|||||||||||:||
Mouse   856 EFLEAAESFELGSTSGTSGNISQDLGDLLDEDE--GSPPKKSRFEFFDNWDSFSSP 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		18/18 (100%)
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30		23/24 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238		84/223 (38%)
		HARP	248..302	CDD:462166	36/53 (68%)
		HARP	343..397	CDD:462166	39/53 (74%)
		HepA	<423..856	CDD:440319	380/432 (88%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	191/208 (92%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		16/16 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934		17/29 (59%)
Smarcal1	NP_061287.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..198		110/243 (45%)
		Mediates interaction with RPA2. /evidence=ECO:0000250	2..29		26/27 (96%)
		Mediates interaction with RPA2. /evidence=ECO:0000250|UniProtKB:Q9NZC9	5..29		23/24 (96%)
		HARP	214..268	CDD:462166	36/53 (68%)
		HepA	<329..809	CDD:440319	417/480 (87%)
		DEXHc_HARP_SMARCAL1	395..604	CDD:350768	191/208 (92%)
		DESH box	508..511		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NZC9	603..620		16/16 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	868..896		17/29 (59%)