Protein Alignment SMARCAL1 and Mi-2

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Alignment Length: 995
• Identity: 210/995 - (21%)
• Similarity: 342/995 - (34%)
• Gaps: 318/995 - (31%)

Human    83 DQRPHDSHSFQAK--------GIWKKPEEMPTACPGHSPRSQMALT------------GISPPLA 127
            |..|...|:|...        |.|:.|.   .:||..:.:::..:|            ..|....
  Fly   454 DSCPSAYHTFCLNPPLDTIPDGDWRCPR---CSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSK 515

Human   128 QSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPKSSQETPAHSSGQPPRDAKLEA 192
            .|...|.:..:..:.:...|.:..||::.     ..|.|| ..:|.|.  .:...:||   |.|.
  Fly   516 NSNSRVREYFIKWHNMSYWHCEWVPEVQL-----DVHHPL-MIRSFQR--KYDMEEPP---KFEE 569

Human   193 KTAKASPSGQNISYIHSSSESVTPRTEGRLQQ----KSGSS-----VQKGVNSQKGKCVRNGDRF 248
            ...:|....:.|.. |.....:....:..:.:    |:|..     ||:.:|.   :..|:|
  Fly   570 SLDEADTRYKRIQR-HKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINH---RTARDG--- 627

Human   249 QVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPLEWAYGSSESPS 313
                  :...:..::.||.     |..||....:|...|.:|
  Fly   628 ------STMYLVKWRELPY-----DKSTWEEEGDDIQGLRQA----------------------- 658

Human   314 TSSEGQAGLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLEE 378
                                             |.|.|||.|:.....::....|::|     ..
  Fly   659 ---------------------------------IDYYQDLRAVCTSETTQSRSKKSKK-----GR 685

Human   379 HSKL-IAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLS---EVDPKLVS----N 435
            .||| :......|.....|                    .|:.|..||.   |..|..:.    .
  Fly   686 KSKLKVEDDEDRPVKHYTP--------------------PPEKPTTDLKKKYEDQPAFLEGTGMQ 730

Human   436 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICIAAFYRKE----WPLLVVVPSSVRFTW 493
            |.|:|..|:|   ::..:|...:|||:||||||||.:.......||    .|.||.||.|....|
  Fly   731 LHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNW 795

Human   494 EQAFLRWLPSLSPDCINVVVTGKDRLTAGLINIVSFD----LLSKLEKQLKTPFK---------- 544
            |:.|..|.|...  || ..:..||.......|.:||:    ..||:.:...|.:|
  Fly   796 EREFELWAPDFY--CI-TYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYEL 857

Human   545 --------------VVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQII 595
                          |:::||:|.||::::...|.........|  :||:|||..:...||:..:.
  Fly   858 ISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYK--LLLTGTPLQNNLEELFHLLN 920

Human   596 AVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEEAV----------MLRRLKSDV 650
            .:....|....||...:.|..:                    ||.|          ||||||:||
  Fly   921 FLSRDKFNDLQAFQGEFADVSK--------------------EEQVKRLHEMLGPHMLRRLKTDV 965

Human   651 LSQLPAKQRKIVVIAPGRINARTRAALDAAAKE----MTTKDKTKQQQKD-----ALI------- 699
            |..:|:|...||           |..|.|..|:    :.||:......|.     :||
  Fly   966 LKNMPSKSEFIV-----------RVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLK 1019

Human   700 -------LFFNRTAEAKIPS-----------------VIEYILDLLESGREKFLVFAHHKVVLDA 740
                   ||.:...||...:                 ::..:|..|::...:.|:|:....:||.
  Fly  1020 KCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDI 1084

Human   741 ITQELERKHVQHIRIDGSTSSAEREDLCQQFQL-SERHAVAVLSITAANMGLTFSSADLVVFAEL 804
            :...||.:..::.||||..:...|::...:|.. ..:..|.:||..|..:|:..::||.|:..:.
  Fly  1085 LEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDS 1149

Human   805 FWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEK-----IKVLAEAGLSETNFS 864
            .|||...|||..|.|||||.:.|.|:..|.:.:.::.:..:.:.|     :.|....|....||:
  Fly  1150 DWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFT 1214

Human   865 E------MTESTDYLYK-DPKQQKI-YD-----------------------LFQKSF-------- 890
            :      :...|:.|:| |.|::.| ||                       .:..||
  Fly  1215 KQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATK 1279

Human   891 -EKEGSDMELL-EAAESFDP 908
             |:|..:.|:: :.||:.||
  Fly  1280 EEEEEEETEIIKQDAENSDP 1299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238		33/183 (18%)
		HARP	248..302	CDD:462166	8/53 (15%)
		HARP	343..397	CDD:462166	12/54 (22%)
		HepA	<423..856	CDD:440319	132/530 (25%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	65/253 (26%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		9/16 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934		3/5 (60%)
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007	7/30 (23%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	11/75 (15%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	15/126 (12%)
		PLN03142	720..>1234	CDD:215601	135/549 (25%)
		DUF1087	<1292..1334	CDD:461922	4/8 (50%)
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358