Protein Alignment SMARCAL1 and ino80

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_001018299.1
• Gene: ino80 / 3361566
• PomBaseID: SPAC29B12.01
• Length: 1604
• Species: Schizosaccharomyces pombe
• Alignment Length: 1277
• Identity: 229/1277 - (17%)
• Similarity: 401/1277 - (31%)
• Gaps: 543/1277 - (42%)

Human     7 EEQRKKIEENRQKALARRAEK------------------------LLAEQHQRTSSGTSIAGNPF 47
            ||::||..|.:.:.|...|:|                        .|:.:....|..|.....|.
pombe   406 EEKKKKEREEQVRLLQESADKDAEMNEASTATSENEDLKDDLSLADLSSKKTANSQATENNNTPS 470

Human    48 QAKQGPSQNFPRESCKPVSHGVIFKQQNLSSSSNADQRPHDSH--SFQAKGIWKKPEEMPTACPG 110
            :||. .:::..|...|...     .:..|||.:|.|...:|::  |.|:.|:....|..|.....
pombe   471 KAKV-KAESKVRSKAKSDK-----SRAKLSSDTNKDSEKNDNNDASLQSAGVASDGESSPETPLT 529

Human   111 HSPRSQMALTGISPPLA-----------QSPPEVPK------QQLLSYELGQGHAQASPEIRFTP 158
            .:.:|:.|.   :..||           :|.|:..|      ||..:....:|..:.|.:  .|.
pombe   530 KASKSKKAK---ASKLANDTSKNANGETKSTPKKSKKKTSKAQQEANSTTAEGKEKLSGD--STE 589

Human   159 FANPTHKPLAKPKSSQETPAHSSGQPPRDAKLEAKTAKASPSGQNISYIHSSSESVTPRTEGRLQ 223
            ..|.|:    |..|:::|.|:::...|...|...:|.:     |.:  |...:....||....:|
pombe   590 TGNSTN----KEASTEDTKANATASAPNKKKKTVETLQ-----QQV--IKEIARKEIPRVYKIIQ 643

Human   224 QKSGSSVQKGVNSQKGK--CVRNGDRFQVLIGYNAELIAVFKTLPSKNYDPDTKT---------- 276
            |   :...:..|::|..  |.|...|:|            |:|: ..|.|..||.
pombe   644 Q---NQYNRSTNARKTSQLCGREARRWQ------------FRTI-KNNKDMQTKAKRAMRETMVF 692

Human   277 WNFSMNDYSALMKAAQSLPTVNLQPLEWAYGSSESPSTSSEGQA--------------------- 320
            |..:......|.|.|:.      :.|:.|  ..|.....|..||
pombe   693 WKRNERVERDLRKKAER------EALDRA--KKEEELRESRRQARKLDFLITQTELYSHFVGRKM 749

Human   321 ----GLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYDVKTRKWSF-LLEEHS 380
                .||||.:.:.|             ::|::..|     ::.|.||..|::.:.:. ...|||
pombe   750 DREQDLPSATNTASV-------------SEINFDSD-----EEEDIRRLAVESAQEAVQKAREHS 796

Human   381 KLIAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVS----------- 434
            :|                      |.:..:::..:.:.|:.|.:::..:|.||:
pombe   797 QL----------------------FDANRQQSPNNSSSDMNEGEMNFQNPTLVNAFEVKQPKMLM 839

Human   435 -NLMPFQRAGVNF---AIAKGGRLLLADDMGLGKTIQAICIAAFYRKE---W-PLLVVVPSSVRF 491
             .|..:|..|:|:   ...:|...:|||:||||||:|:|.:.|:..:.   | |.||:.|:|...
pombe   840 CKLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISVMAYLAETHNIWGPFLVIAPASTLH 904

Human   492 TWEQAFLRWLPSLSPDCINVVVTGKDRLTAGLINIVSFDLLSKLEKQLKTPFKVV---------- 546
            .|:|...|::|.|.  ||....:.|||..     :..|.....:.....:||.||
pombe   905 NWQQEITRFVPKLK--CIPYWGSTKDRKI-----LRKFWCRKNMTYDENSPFHVVVTSYQLVVLD 962

Human   547 ------------IIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKP 599
                        |:||:..:|:|.::|.::.: ..|...| :||:|||..:...||:..:..:.|
pombe   963 AQYFQSVKWQYMILDEAQAIKSSSSSRWKSLL-AFKCRNR-LLLTGTPIQNTMQELWALLHFIMP 1025

Human   600 TFFPQFHAFGLRYCDAKRMPWGWDYS--------GSSNLGELKL----LLEEAVMLRRLKSDVLS 652
            :.|...:.|.         .|   :|        .::.|.|.:|    ::.:..||||:|.:|.|
pombe  1026 SLFDSHNEFS---------EW---FSKDIESHAQSNTQLNEQQLKRLHMILKPFMLRRVKKNVQS 1078

Human   653 QLPAK--------------------QRKI------------------------------------ 661
            :|..|                    :|:|
pombe  1079 ELGEKIEKEVYCDLTQRQKILYQALRRQISIAELLEKAILGGDDTVASIMNLVMQFRKVCNHPDL 1143

Human   662 ---------------------------------------------------VVIAPGRINAR--- 672
                                                               ::..||...:|
pombe  1144 FEREDVRSPLSLATWSKSIYINREGNFLDVPYNTRNFITFSIPRLLYEQGGILSVPGLNTSRGFE 1208

Human   673 ------------------------------------------------------TRAALDAAAKE 683
                                                                  ..|...::.||
pombe  1209 TKYLYNLMNIWNPEYTNDSIKSNPEGSPFSWLRFVDESPQTLFQTFQNPVVHYLDEAEASSSLKE 1273

Human   684 ----------------------------------------------------------MTTKDKT 690
                                                                      :|..|..
pombe  1274 EQLCRQEFCYGKDYSNVRKMLLLPKSITKVDVLGSDFKEDSPFYHLTHVLEESDSQLDLTLLDSV 1338

Human   691 KQQ------------------------QKDAL-------------ILFFNRTAEAK--------- 709
            ..|                        |:|.|             .|..|..|.:|
pombe  1339 LVQRASAPPIDIYCPGSRQFTVLQSRFQRDHLWSHYLYQPLKGEEDLIINNQAVSKLPIPRKPLL 1403

Human   710 --------------IPSVIEYILDL------------LESGREKFLVFAHHKVVLDAITQELERK 748
                          |||::.:|.|.            |::...:.|::.....::|.:.:.|..:
pombe  1404 PSFGIAKGSYSNVRIPSMLRFIADSGKLSKLDKLLVELKANDHRVLIYFQMTRMIDLMEEYLTFR 1468

Human   749 HVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQ 813
            ..:::|:|||:..::|.|:..::|......|.:||..|..:|:..::||.|:|.:..|||.:..|
pombe  1469 QYKYLRLDGSSKISQRRDMVTEWQTRPELFVFLLSTRAGGLGINLTAADTVIFYDSDWNPSIDSQ 1533

Human   814 AEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAE 855
            |.||.|||||...|.::..:.:||        |:|:|.:.|:
pombe  1534 AMDRAHRIGQQKQVTVYRFITRGT--------IEERIVIRAK 1567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		5/12 (42%)
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30		8/46 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238		48/253 (19%)
		HARP	248..302	CDD:462166	11/63 (17%)
		HARP	343..397	CDD:462166	10/54 (19%)
		HepA	<423..856	CDD:440319	135/780 (17%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	63/249 (25%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		8/36 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934
ino80	NP_001018299.1	MSCRAMM_ClfA	452..>638	CDD:468110	43/207 (21%)
		HepA	658..>1147	CDD:440319	113/570 (20%)
		DEXQc_INO80	842..1071	CDD:350760	63/249 (25%)
		SF2_C_SNF	1428..1553	CDD:350180	33/124 (27%)