Protein Alignment SMARCAL1 and rad8

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_001342793.1
• Gene: rad8 / 3361391
• PomBaseID: SPAC13G6.01C
• Length: 1133
• Species: Schizosaccharomyces pombe
• Alignment Length: 1103
• Identity: 214/1103 - (19%)
• Similarity: 351/1103 - (31%)
• Gaps: 430/1103 - (38%)

Human    54 SQNFPRESCKPVSHGVIFKQQNLSSSSNADQRPHDSHSFQAKGIWKKPEEMPTACPGHSPRSQMA 118
            ::|..:::...||..:     ||||:|:......|......|                  :|:.|
pombe   148 NRNTNKKALNAVSPSL-----NLSSNSSVQDVSIDKEEMMKK------------------QSRNA 189

Human   119 LTGISPPLAQSPPEVPKQQLLSY-----------ELGQGHAQASPEIRFTPFANPTHKPLAKPKS 172
            ||    ||...   :.|.:|:.|           ..|....||...|.           |.:.|.
pombe   190 LT----PLDFI---MKKNELMKYIGCFGVEAYSTASGTRTLQAGERIY-----------LERQKL 236

Human   173 SQETPAHSSGQPPRDAKLEAKTAKASPSGQNISYIHSSSESVTPRTEGRLQQKSGSSV----QKG 233
            |.::.:.:|.:     |.:..:..:|.....:.:.:|....:     |:|..:..|.:    ::|
pombe   237 SIKSQSRNSRK-----KSKLLSINSSCYSNIVRFCNSDHHEI-----GKLPTEVASVISTLMEQG 291

Human   234 VNSQKGKCVRNGD--RFQVLIGYNAEL-IAVFKTL--PSKNYDPDTKTWNFSMNDYSALMKA--A 291
            ..|.:..|:.:.:  ||    |.|..| :..|..:  ||.|..|.|...| ||.:....:||  |
pombe   292 FWSFEAICIYSDNIIRF----GSNVTLQVYCFINVNHPSLNRSPFTLATN-SMQEEEEHLKASFA 351

Human   292 QS--------------------------------LPTVNLQPLEWAYGSSESPSTSSEGQ----- 319
            |:                                |.|.:|........|..:||::.:.:
pombe   352 QNKRDHLLRLFTWIALEPDLEDCNTKESIHIDDILKTSSLPEARDESNSDLTPSSTEDEEDVVSD 416

Human   320 -------------AGLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYDVKTRK 371
                         |.|||||..|                  :::.||         |.|..:...
pombe   417 QLAILYDKVKTSGAELPSAPKPS------------------TFALDL---------REYQKQALY 454

Human   372 WSFLLEEHSKLIAKVRCLPQVQLD-PLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVD------ 429
            |....||            .||.| ..|....|....:..|.|     :.||......|
pombe   455 WMCCKEE------------GVQSDGSAPKLHPLWSRFRFPKDS-----EFPEFFKCSSDDDNTHF 502

Human   430 ---------PKLVSNLMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQAICI----AAFYRKEWP- 480
                     ..|..|.||:.|.|:           |||:|||||||:.:.:    ..|...|.|
pombe   503 YVNLYTGETTMLFPNSMPYHRGGI-----------LADEMGLGKTIEVLSLIHSRPCFSTDEIPE 556

Human   481 ---------------LLVVVPSSVRFTWEQAFLR-----------WLPSLSP-DCINVVVTGKDR 518
                           .|||.|.|:...|.....:           :..|..| |..:.|:   |.
pombe   557 AFRHSKPSLPVASRTTLVVAPMSLLDQWHSEACKVSQGTKFRSMIYYGSEKPLDLKSCVI---DT 618

Human   519 LTAGLINIVSFD-LLSKLEKQLKTP--FKV----VIIDESHFLKNSRTARCRAAMPVLKVAKRVI 576
            .||.||.|.|:. |||:..:|..:.  |.|    |::||.|.::|..:...:|...:....:.||
pombe   619 STAPLIIITSYGVLLSEFSQQSHSSGLFSVHWFRVVLDEGHNIRNRESKTAKACHSISSQNRWVI 683

Human   577 LLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPW----GWD------YSGSSNLG 631
              :|||.:::..:||:.|         :|    :||     .||    .|.      |.....|.
pombe   684 --TGTPIVNKLDDLYSLI---------KF----MRY-----EPWCNYTYWQTFVSLPYQSKDVLK 728

Human   632 ELKLL--LEEAVMLRRLK------SDVLSQLPAK------------QRKI--------------- 661
            .|.::  :.|.::|||.|      .:.:..||.|            :|||
pombe   729 ALNVVQSILEFLVLRRTKETKDRNGNSIVTLPPKTVKIEYLDFSDSERKIYDSLYTKAKSTVNAN 793

Human   662 ---------------------------VVIAPGRINARTRAALDAAAKE---------MTTK--- 687
                                       |:::...||:.|....:.:.::         :|.|
pombe   794 IVAGTLFRNYTTILGLLLRLRQACCDPVLLSNMTINSETFDDFEFSVEQFNSLINQFVVTGKPIP 858

Human   688 ------DKTK--------------------------------------QQQKDALIL-------- 700
                  |..|                                      |.||...|:
pombe   859 SDILKIDTLKSFEALITECPICCNEPIQNPLLLNCKHACCGDCLSEHIQYQKRRNIIPPLCHTCR 923

Human   701 --------------------------------FFNRTAEAKIPSVIEYILDLLESGR-EKFLVFA 732
                                            ::||....|:..::..:..|..|.. ||.::|:
pombe   924 QPFNEQDVYKPFFVKNNGTQSTLLVGEEVKWKYWNRLQSVKLNGLLGQLRQLTHSSEPEKVVIFS 988

Human   733 HHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMGLTFSSAD 797
            .....||.|...||.:.:.:.|.||:.|...|....:.|:......|.::|:.|..:||..:.|:
pombe   989 QFTTFLDIIADVLESEKMGYARFDGTMSQQMRSTALETFRNDPDVNVLIISLKAGGVGLNLTCAN 1053

Human   798 LVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAEAGLSE 860
            .|...:.:|:..|..||.||:||:||...|.:...:.:.|.::.:..:.:.|..:....|:||
pombe  1054 HVFIMDPWWSWSVEAQAIDRIHRLGQEKPVFVTRYIVRDTVEERMLKIQERKNFITGTLGMSE 1116

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238		35/198 (18%)
		HARP	248..302	CDD:462166	20/90 (22%)
		HARP	343..397	CDD:462166	10/54 (19%)
		HepA	<423..856	CDD:440319	128/655 (20%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	65/259 (25%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		7/34 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934
rad8	NP_001342793.1	UBA_4	71..112	CDD:464207
		HIRAN	209..316	CDD:214906	22/131 (17%)
		HepA	<354..1105	CDD:440319	156/828 (19%)
		RING-HC_SpRad8-like	871..932	CDD:438234	4/60 (7%)