Protein Alignment SMARCAL1 and okr

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Alignment Length: 647
• Identity: 151/647 - (23%)
• Similarity: 250/647 - (38%)
• Gaps: 147/647 - (22%)

Human   343 FEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLEEH------SKLIAKVRCLPQVQL-DPLPTT 400
            |.|:..|.   :|:.|        |..||:...::.:      .:::...||:.:..| ||:...
  Fly    66 FTANSEYE---LAIAK--------VLARKFKVPMDNYVPDYGGKRVLGVRRCISRRPLHDPMACN 119

Human   401 LTLAF--ASQLKKTSLSLTPDVPEADLSEVDPKLVSNLMPFQRAGVNF--AIAKGGR-----LLL 456
            ..:.|  .:..:...:.:.|......: .|||.|.:.|.|.||.||.|  ...:|.|     .::
  Fly   120 ALVLFHPPAYTEHERMGMDPTKVLVHV-VVDPLLSNILRPHQREGVRFMYECVEGKRGNFNGCIM 183

Human   457 ADDMGLGKTIQAICIAAFYRKEWPLL--------------VVVPSSVRFTWEQAFLRWLPSLSPD 507
            ||:||||||:|.:.:.      |.||              ||.|||:...||:.|.:||.....
  Fly   184 ADEMGLGKTLQCVTLV------WTLLRQGPECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLL- 241

Human   508 CINVVVTGKDRLTAGLINIVSFDLLSKLEKQLKTP--------FKV------------VIIDESH 552
            |:.:....|:.      .|.:.:..|....:|.||        |::            ||.||.|
  Fly   242 CLPMEGGTKEN------TIRALEQFSMTSARLGTPVLLISYETFRIYAEILCKYEVGMVICDEGH 300

Human   553 FLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKR 617
            .||||.....:|.|. || .||.:||||||..:...|.|:.:..|.|........|...:..|..
  Fly   301 RLKNSDNLTYQALMG-LK-TKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAIL 363

Human   618 MPWGWDYS------GSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQRKIVV------------- 663
            .....|.:      ......||..|:::.: :||....:...||.|...::.
  Fly   364 RGQNTDSTEQERQRAIEKTQELIGLVDQCI-IRRTNQILTKYLPVKFEMVICAKLTAIQLELYTN 427

Human   664 ------IAPGRINARTRAALDAAAKEMTTKDKTKQQQKDALILFFNRTAEAK--------IPS-- 712
                  :.....:...:|:|.|.| ::||..|......   :::...||..|        :||
  Fly   428 FLKSDQVRRSLADCNEKASLTALA-DITTLKKICSHPD---LIYEKLTAREKGFENSQNVLPSNY 488

Human   713 --------------VIEYILDLLES-GREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSA 762
                          :::::|..:.: |.:|.::.:::...||...|...::....:|:||:.|..
  Fly   489 KPKDLNPELSGKFMLLDFMLAAIRAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIK 553

Human   763 EREDLCQQFQLSERHA-VAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSS 826
            :|..:..:|...|..: :.:||..|...||....|:.:...:..|||....||..||.|.||...
  Fly   554 KRSKVVDRFNDPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKP 618

Human   827 VGIHYLVAKGTADDYLWPLIQEKI--KVLAEAGLSETNFSEMTESTDYLYKDPKQQKIYDLF 886
            ..|:.|||.|:        |:|||  :...:..||.|.......:..:..:|    .:.|||
  Fly   619 CYIYRLVASGS--------IEEKILQRQTHKKSLSSTIIDNNESAEKHFTRD----DLKDLF 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238
		HARP	248..302	CDD:462166
		HARP	343..397	CDD:462166	12/60 (20%)
		HepA	<423..856	CDD:440319	129/526 (25%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	70/255 (27%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		5/16 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137	10/57 (18%)
		HepA	<156..650	CDD:440319	128/521 (25%)
		DEXHc_RAD54A	156..396	CDD:350825	70/255 (27%)