DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCAL1 and kis

DIOPT Version :10

Sequence 1:NP_054859.2 Gene:SMARCAL1 / 50485 HGNCID:11102 Length:954 Species:Homo sapiens
Sequence 2:NP_001137761.1 Gene:kis / 33185 FlyBaseID:FBgn0266557 Length:5517 Species:Drosophila melanogaster


Alignment Length:1027 Identity:221/1027 - (21%)
Similarity:352/1027 - (34%) Gaps:307/1027 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   128 QSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPK------------SSQETPAHS 180
            :..|| |||.....||.:.               .|.||....|            .|:||...|
  Fly  1667 EKAPE-PKQDEEKSELDEA---------------TTDKPEGDEKFKTEGESKKDLTDSEETKLES 1715

Human   181 SG--------QPPRDAKLEAKTAKASPSGQNISYIHSSSESVTPRTEGRLQQKSGSSVQKGVNSQ 237
            |.        ..|.|:|...:..|.....:....:..|.:...|..:....:...:|  |.:...
  Fly  1716 SAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENS--KAIEED 1778

Human   238 KGKCVRNGDRFQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSM-----NDYSALMKA--AQSLP 295
            |...|...|..:                     :|:|......:     :|.||:.||  :....
  Fly  1779 KSSTVLTADHAK---------------------EPETVLEKMEVDEKANDDQSAVSKAEGSDEKS 1822

Human   296 TVNLQPLEWAYGSSESPSTSSEGQ-----AGLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIA 355
            |.:..| |.|.......|...||:     .|..|....:..|          .|||:....:.:.
  Fly  1823 TDDSNP-EEATTEKNKESLEIEGEKERVKEGEESVKKENDEK----------TEADMENKPEPVF 1876

Human   356 LFKQMDSRRYDVKTRKWSF----------LLEEHSKLIAKVRCLPQ-----------VQLDPLPT 399
            :    |...|.||.|.:|:          ||:...::.||:|...|           ::.:|...
  Fly  1877 I----DVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQ 1937

Human   400 TLT-----LAFASQLKKTSLSLT-------PDVPEADLS-----EVD------------------ 429
            ..|     |..:....:||...|       ..:|..|.:     :||                  
  Fly  1938 DFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSE 2002

Human   430 --------PKL------------VSNLMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICI 471
                    |:|            .::|.|:|..|:|   |:.......:|||:||||||||::..
  Fly  2003 WKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTF 2067

Human   472 AAF---YRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVV-----VTGKDRLTAGLINIVS 528
            ...   |....|.||:.|.|....|::.|..|..      :|||     ||.|..       |..
  Fly  2068 VHSVYEYGIRGPFLVIAPLSTIPNWQREFEGWTD------MNVVVYHGSVTSKQM-------IQD 2119

Human   529 FDLLSKLE--KQLKTPFK------------------------VVIIDESHFLKNSRTARCRAAMP 567
            ::...|.|  |.||.|.|                        :.:|||:|.||| |..:....:.
  Fly  2120 YEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKN-RNCKLLEGLR 2183

Human   568 VLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGE 632
            .|.:..|| ||||||..:..:||::.:..::|:.|.....|...:...:.         ...:.:
  Fly  2184 QLNLEHRV-LLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRT---------EEEVNK 2238

Human   633 LKLLLEEAVMLRRLKSDVLSQLPAKQRKIVVIAPGRINAR----------------TRAA----- 676
            |:.|| :.:||||||.||...|..|:..|:.:....|..:                |.:|     
  Fly  2239 LQALL-KPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNL 2302

Human   677 ---------------LDAAAKEMTTKDKTKQQQKDALILFFNRTAEAKIPSVIEYILDLLESGRE 726
                           |...|:|....|...|..:|....:.|....|....:|:.:|..|::...
  Fly  2303 MNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGH 2367

Human   727 KFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL--SERHAVAVLSITAANM 789
            :.|:|:.....||.:...|..:.....||||......|::...::..  |:|. |.:|...|..:
  Fly  2368 RVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRF-VFLLCTKAGGL 2431

Human   790 GLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLA 854
            |:..::||.|:..:..|||...:||:.|.|||||...|.|:.|:.:.|.:..::.      |...
  Fly  2432 GINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFD------KASM 2490

Human   855 EAGLSETNFSEMTE--STDYLYKDPKQQKIYDLFQKSFEKEGSDMELLEAAESF----------- 906
            :.||.:.....|..  |.|...|...:::|.||.:|.  ..|:.|:...|.:.|           
  Fly  2491 KLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKG--AYGAVMDDDNAGDKFCEEDIDSILKR 2553

Human   907 ---------DPGSA-SGTSGSSSQNMGD-TLDESSLTASPQKKRRFEFFDNW 947
                     :.||. |..|.::|.|..| |:|:.            :|:..|
  Fly  2554 RTQVITMESEKGSTFSKASFAASGNRSDITIDDP------------DFWTKW 2593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCAL1NP_054859.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198 5..30
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..238 24/129 (19%)
HARP 248..302 CDD:462166 8/60 (13%)
HARP 343..397 CDD:462166 15/74 (20%)
HepA <423..856 CDD:440319 130/550 (24%)
DEXHc_HARP_SMARCAL1 436..645 CDD:350768 67/245 (27%)
DESH box 549..552 2/2 (100%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831 644..661 8/16 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 904..934 10/51 (20%)
kisNP_001137761.1 Atrophin-1 221..>533 CDD:460830
Med15 <1056..>1265 CDD:312941
PRK12678 1319..>1500 CDD:237171
PTZ00121 <1419..1923 CDD:173412 59/309 (19%)
CD1_tandem_CHD5-9_like 1851..1918 CDD:349315 17/80 (21%)
CD2_tandem_CHD5-9_like 1937..1995 CDD:349310 9/57 (16%)
PLN03142 2029..>2606 CDD:215601 150/611 (25%)
PTZ00341 <3662..3887 CDD:173534
BRK 4568..4611 CDD:462196
Blue background indicates that the domain is not in the aligned region.

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